Effects of melatonin on heart health in patients with cardiomyopathy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the cardioprotective effects of melatonin in adult patients diagnosed with cardiomyopathy. Participants will receive either melatonin or a placebo while maintaining their standard cardiomyopathy medications. The research aims to assess melatonin's potential to improve cardiac function and mitigate myocardial injury through its antioxidant and anti-inflammatory properties. The study is designed to provide insights into a novel therapeutic strategy for a condition that currently has limited treatment options.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥18 years) with a confirmed diagnosis of cardiomyopathy based on clinical, echocardiographic, or imaging findings. .
* Stable condition on standard cardiomyopathy medications (e.g., ACE inhibitors, beta-blockers).
* Ability to provide informed consent.

Exclusion Criteria:

* Recent hospitalization for cardiomyopathy exacerbation (within the last 3 months).
* Severe kidney or liver impairment.
* Use of other investigational drugs or antioxidants.
* Pregnancy or planning to be pregnant in the next 6 months
* Previous known hypersensitivity to melatonin.
* Presence of atrial fibrillation or other significant arrhythmias at baseline.
* Participation in another research.

Where it's running

• Mansoura University Hospital
  Dakahlia, Egypt, Mansoura, Egypt Recruiting

Study contacts

• Study coordinator: Reem Alaa, Bachelor of Pharmacy (2023)
• Email: memoalaa19999@gmail.com
• Phone: +201124425525

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.