Condition

Genetic Predisposition clinical trials and research

• 29Clinical trials
• 6NIH research projects
• 27Countries

Newest Genetic Predisposition clinical trials

All recruiting trials (29)

• Transition outcomes for adolescents and young adults with a cancer predisposition.

  See if young adults with a genetic cancer predisposition establish and keep up care with adult providers and follow recommended cancer surveillance after they leave pediatric care at St. Jude.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07456904

• How genes and alcohol interact to affect liver cancer risk

  This project will test if certain gene variants together with alcohol use and metabolic problems raise the risk of liver cancer in people with fatty or cryptogenic liver disease, especially men with diabetes or obesity.

  Recruiting Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan, Milano · NCT07272200

• Topical 5% minoxidil to boost blood flow and skin‑flap survival during breast reconstruction

  This trial will test whether applying 5% topical minoxidil to one breast before bilateral risk‑reducing mastectomy with immediate reconstruction improves blood flow and skin‑flap survival compared with a placebo on the other breast.

  Recruiting Phase 1 Duke University · Durham, North Carolina · NCT07264790

• Slow-SPEED: Can a smartphone app help people with prodromal Parkinson's stay more active?

  This trial tests whether a remote smartphone app can help people with a LRRK2 G2019S or GBA1 N370S mutation increase daily activity and see if exercise might slow prodromal Parkinson's signs.

  Recruiting Radboud University Medical Center · Rochester, New York and 1 other locations · NCT06993142

• Understanding how genetics and lifestyle affect endometrial cancer recurrence

  This study is trying to see how genetics and lifestyle factors like obesity and diabetes affect the chances of endometrial cancer coming back in patients.

  Recruiting Faculty Hospital Kralovske Vinohrady · Prague · NCT06680791

• Biobank for prostate tissue samples and genetic data

  This study is collecting prostate tissue samples and DNA from men with inherited gene mutations to see how these genetic factors affect prostate cancer and treatment responses compared to men without these mutations.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06659614

• Evaluating endomyocardial biopsy and tailored treatments for pediatric inflammatory heart disease

  This study is testing how a heart tissue sample and personalized treatments can help kids with inflammatory heart disease, especially those with myocarditis and heart rhythm issues.

  Recruiting Scientific Institute San Raffaele · Milan, Milano · NCT06591260

• Understanding how trihexyphenidyl works in children with dystonic cerebral palsy

  This study is testing how well the medication trihexyphenidyl works for children with dystonic cerebral palsy and if their genes affect how the drug works.

  Recruiting Phase 1 Children's Mercy Hospital Kansas City · Kansas City, Missouri · NCT06554288

• Evaluating the risk of liver cancer in patients with fatty liver disease

  This study is testing how fatty liver disease might lead to liver cancer by looking at genetic and metabolic factors in patients with this condition.

  Recruiting Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan, Milano · NCT06523179

• Investigating biomarkers in patients with genetic cardiomyopathy

  This study is trying to find new markers in blood and other tests to help identify people with a family history of genetic heart disease who might develop symptoms, so they can be monitored more easily and effectively.

  Recruiting NHS Greater Glasgow and Clyde · Glasgow · NCT06446271

• Registry of genetic, molecular, and diversity differences in women with acute coronary syndrome

  This project will collect clinical, genetic, biochemical, and molecular information from women with acute coronary syndrome across Italy to see if differences by age, ethnicity, or disease type relate to presentation and outcomes.

  Recruiting at 4 sites IRCCS San Raffaele · Milan, Italy Milan and 3 other locations · NCT06441942

• Advancing genomic medicine using electronic health records

  This study is trying to see if using electronic health records and helpful reminders can get more patients tested for genetic conditions in a way that doctors can easily use.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT06377033

• Understanding genetic factors that affect weight loss after bariatric surgery

  This study is trying to find out if certain genes can help predict how well people with severe obesity will lose weight after having bariatric surgery.

  Recruiting Institut de Recerca Biomèdica de Lleida · Lleida, Leida · NCT06226194

• Using a chatbot or genetic counselor for cancer genetic screening in rural areas

  This study is testing whether a chatbot or a genetic counselor is better at helping people in rural areas understand cancer genetic screening and decide to get tested for gene mutations.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06089421

• Understanding genetic effects on response to oral semaglutide in type 2 diabetes

  This study is testing how different genes affect how well people with type 2 diabetes respond to the oral medication semaglutide.

  Recruiting Phase 4 Massachusetts General Hospital · Boston, Massachusetts · NCT06003153

• International Childhood Leukemia Microbiome and Metabolome Cohort

  This study is trying to see how nutrition affects treatment and recovery in children aged 3 to 18 who have just been diagnosed with acute lymphoblastic leukemia.

  Recruiting at 7 sites Columbia University · New York, New York and 7 other locations · NCT05929976

• Understanding Parent-Child Communication About Cancer Risk in Young People

  This study looks at how parents talk to their kids and young adults about their genetic test results for cancer risk to see what helps or makes it harder for them to communicate.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05849155

• Genetic testing for kidney disease risk in African Americans

  This study is trying to see if knowing about certain genetic risks for kidney disease helps African Americans with high blood pressure take better care of their health.

  Recruiting St. Louis University · St Louis, Missouri · NCT05656261

• Understanding inherited risk factors for lung cancer

  This study is trying to understand how genetic factors affect the risk of lung cancer in people with little tobacco exposure, especially those with family histories of the disease.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT05587439

• Research on early detection of pancreatic cancer

  This study is trying to find better ways to detect pancreatic cancer early by looking at people who are at high risk because of their family history or genetics.

  Recruiting at 57 sites Arbor Research Collaborative for Health · Phoenix, Arizona and 61 other locations · NCT04970056

• Evaluating a genetic test for prostate cancer risk

  This study is testing a genetic test to see if it can help men at high risk for prostate cancer understand their risk better and make informed decisions about screening and treatment.

  Recruiting Institute of Cancer Research, United Kingdom · Sutton, England · NCT04763317

• Evaluating genetic testing methods for rare diseases and familial tumor syndromes

  This study looks at how well new genetic testing methods can help people with rare diseases and their families understand their risk for these conditions.

  Recruiting University Hospital Tuebingen · Tübingen · NCT04731857

• Identifying genetic risks for complications in childhood cancer patients in Switzerland

  This study is trying to find out if certain genetic differences can help explain the complications that childhood cancer patients in Switzerland might face after their treatment.

  Recruiting University Hospital, Geneva · Geneva · NCT04702321

• Evaluating endomyocardial biopsy and tailored treatments for inflammatory heart disease

  This study is trying to see if a heart tissue test and personalized treatments can help people with inflammatory heart disease, especially those with myocarditis and heart rhythm issues.

  Recruiting Scientific Institute San Raffaele · Milan, Milano · NCT04521790

• Identifying genetic factors in early-onset cancer using exome analysis

  This study is trying to find new genetic clues in patients with early-onset cancer who didn't get answers from previous tests to help improve how we understand and diagnose these cancers.

  Recruiting Centre Georges Francois Leclerc · Besançon and 5 other locations · NCT04141462

• Exploring genetic factors in neuropathic pain

  This study is trying to find out if certain genes are linked to neuropathic pain to help understand why some people experience this condition.

  Recruiting at 5 sites Oslo University Hospital · Bergen and 4 other locations · NCT03862365

• Targeted antifungal prevention for patients with acute myeloid leukemia

  This study is testing if a specific antifungal treatment can help patients with acute myeloid leukemia who are getting chemotherapy avoid serious infections.

  Recruiting at 8 sites Centre Hospitalier Universitaire Vaudois · Ghent, Belgium and 8 other locations · NCT03828773

• Research on genetic diseases affecting heart and blood vessels

  This study is trying to learn more about rare genetic heart and blood vessel diseases by collecting information and samples from people who have these conditions, their families, and healthy volunteers.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03538639

• Classifying genetic variants for cancer risk assessment

  This study is testing how to better understand certain genetic changes in cancer-related genes to help patients and their families make informed decisions about their cancer risk and treatment options.

  Recruiting at 55 sites Institut Curie · Bastia, Corsica and 61 other locations · NCT01689584

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Genetic risk factors for heart attack in people with coronary artery disease

  Researchers are studying how genes influence the risk of having a heart attack among people who already have coronary artery disease, with the goal of improving risk prediction and prevention.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11370037

• Understanding Genetic Risks for Heart Attacks in People with Heart Disease

  This project aims to discover the genetic factors that make some people with heart disease more likely to have a heart attack.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11248176

• Investigating genetic factors linked to chronic lymphocytic leukemia (CLL)

  This study is looking at how certain rare genetic changes, especially in the ATM gene, might make some people more likely to develop chronic lymphocytic leukemia (CLL), and it's inviting patients with known ATM gene changes to help us learn more about how these genetics relate to CLL and family cancer history.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11059143

• Understanding genetic factors and misdiagnosis in cancer patients

  This study is looking at how our genes might sometimes lead to incorrect cancer diagnoses, and it's for people in the All of Us program who want to help improve cancer care by sharing their genetic information.

  NIH research Brigham Young University · Provo, United States · NIH-10974720

• Investigating how silica exposure and viral infections contribute to autoimmune diseases

  This study is looking at how exposure to silica and viruses, along with genetic factors, might work together to trigger lupus, an autoimmune disease, and it’s using mice to see if these combined exposures lead to stronger immune responses than just one alone.

  NIH research San Diego Biomedical Research Institute · San Diego, United States · NIH-10832472

• How genetics and medication affect cognitive impairment in people with HIV

  This study is looking at how your genes might affect how well HIV treatment works for preventing memory and thinking problems, and it's for people living with HIV who want to understand more about their health.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10712363

Related topics

Quick answers

How many Genetic Predisposition clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 27 countries. The most sites are in United States (14 trials), Italy (6 trials), France (3 trials), United Kingdom (3 trials), Switzerland (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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