Myocardial Energetics Across Cardiovascular Disease Spectrum Using 31P-MRS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll up to 1,000 participants, including healthy volunteers and patients with heart failure and a range of cardiomyopathies, to characterize myocardial energetic phenotypes. By combining 31P-MRS with multiparametric cardiac MRI, the study aims to define metabolic signatures that relate to structural changes and clinical biomarkers. The primary outcome is the myocardial PCr/ATP ratio, an in vivo marker of energetic impairment, with secondary exploration of relationships to remodeling and function. The trial is centered at the Chinese Academy of Medical Sciences and Fuwai Hospital in Beijing, led by a national sponsor.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>= 18 years
* Healthy volunteers, OR
* Clinical diagnosis of cardiac disease, including non-ischemic cardiomyopathy (hypertrophic, amyloid, or inflammatory), ischemic cardiomyopathy, hypertensive heart disease, or valvular heart disease, OR
* Inherited metabolic cardiomyopathies
* Able to undergo CMR examination and provide written informed consent

Exclusion Criteria:

\* Any contraindication to CMR examination

Where it's running

• Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital
  Beijing, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.