Understanding how increased calcium uptake in mitochondria affects heart function in children with mitochondrial diseases
Metabolic Impact and Mechanism of Enhanced Mitochondrial Calcium Uptake in Mitochondrial Cardiomyopathies
This study is looking at how calcium in tiny parts of cells called mitochondria affects heart energy in kids with mitochondrial cardiomyopathies, hoping to find new ways to help their hearts work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11077867 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial calcium uptake in children suffering from mitochondrial cardiomyopathies, which are severe heart conditions caused by genetic mutations. The study focuses on how calcium signaling within mitochondria can enhance energy production, particularly in the heart, which has high energy demands. By exploring the mechanisms that regulate calcium uptake and its impact on ATP synthesis, the research aims to identify potential therapeutic targets for improving heart function in affected children. The research employs a combination of genetic, biochemical, and physiological approaches in animal models and human samples.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and children diagnosed with mitochondrial cardiomyopathies.
Not a fit: Patients with mitochondrial diseases that do not involve cardiac complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and overall health in children with mitochondrial diseases.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function and calcium signaling, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Chaudhuri, Dipayan — University of Utah
- Study coordinator: Chaudhuri, Dipayan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.