Monitoring brain-derived tau levels in acute ischemic stroke patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the evolution of plasma brain-derived tau (BD-tau) levels in patients diagnosed with acute ischemic stroke. By measuring BD-tau levels every hour from admission to 48 hours post-onset, the study seeks to understand how these levels correlate with infarct progression and patient outcomes. The research builds on previous findings that suggest BD-tau is a sensitive biomarker for brain injury, potentially offering insights into the dynamics of stroke progression and aiding in therapeutic decision-making. The study will include patients presenting within 9 hours of symptom onset with confirmed large- or medium-vessel occlusion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* clinical diagnosis of acute ischemic stroke
* presentation within 9 hours of symptom onset
* large- or medium-vessel occlusion (i.e. an occlusion of the ICA, MCA \[segments M1-M4\], ACA \[segments A1-A3\], basilar artery, or PCA \[segments P1 to P3\]) confirmed by CT or MRI angiography
* at least 18 years of age
* written informed consent

Exclusion Criteria:

* CT or MRI showing intracranial hemorrhage upon admission
* A history of ischemic stroke, subarachnoid hemorrhage, intracerebral hemorrhage, subdural hematoma, epidural hematoma, CNS tumor, meningitis, or encephalitis within the last three months
* dementia
* pre-stroke disability defined as a premorbid modified Rankin Scale score \> 2

Where it's running

• LMU University hospital, LMU Munich
  Munich, Bavaria, Germany Recruiting

Study contacts

• Study coordinator: Steffen Tiedt, MD PhD
• Email: steffen.tiedt@med.uni-muenchen.de
• Phone: +4989440046046

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.