A study on brain health and aging in Bordeaux.
Biobank and Brain Health in Bordeaux. A Population-based Cohort to Study the Biology of Brain and Cognitive Aging in Young Seniors
This study is trying to understand how different factors, like diet and health, affect brain aging and the risk of dementia in people aged 55 and older living in Bordeaux.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2050 (estimated) |
| Ages | 55 Years to 80 Years |
| Sex | All |
| Sponsor | University Hospital, Bordeaux Academic / other |
| Locations | 1 site (Bordeaux, Bordeaux) |
| Trial ID | NCT05322343 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the determinants and natural history of brain aging in a representative sample of 2000 individuals aged 55 and older from the Bordeaux metropolitan area. It employs molecular epidemiology methods to explore various factors, including nutrition, that may influence cognitive aging and the onset of dementia. Participants will undergo a series of assessments, including questionnaires and biological sample collections, to gather comprehensive data on their health and environmental exposures. The study seeks to enhance understanding of cognitive aging and inform prevention strategies.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 55 to 80 living in the Bordeaux metropolitan area who are willing to participate in biological sampling.
Not a fit: Patients under guardianship or those unable to provide consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention strategies for cognitive aging and dementia.
How similar studies have performed: Previous population-based cohorts have successfully contributed to understanding aging and dementia, indicating a strong foundation for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For the main study: 1. live in Bordeaux metropolitan area, 2. be between 55 and 80 years old (included), 3. selected in terms of socioeconomic level, according to a sampling strategy by age groups and income categories representative of the general population between 55 and 80 years of age 4. be affiliated with the social security system, 5. agree to take a blood sample for the biobank. For the MRI sub-study: be between 55 and 75 years old (included). Inclusion criteria for the immune response substudy: be 70 years of age or older or participate in the MRI study; agree to take a supplemental blood sample for this substudy. Exclusion Criteria: For the main study: persons under guardianship (or more generally under protection), unable to give consent to participate. For the MRI sub-study: have a contraindication to MRI examination (pacemaker, a valve prosthesis or any other internal electrical/magnetic device; history of neurosurgery or aneurysm; claustrophobia; presence of metal fragments in the eyes, brain or spinal cord).
Where this trial is running
Bordeaux, Bordeaux
- University Hospital of Bordeaux — Bordeaux, Bordeaux, France (Recruiting)
Study contacts
- Principal investigator: Cécilia SAMIERI, Dr — Bordeaux Population Health Researh Center Inserm
- Study coordinator: Cécilia SAMIERI, Dr
- Email: cecilia.samieri@u-bordeaux.fr
- Phone: 5 57 57 45 15
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.