Multi-domain lifestyle intervention for older adults at risk of cognitive decline in China
A Multi-domain Lifestyle Intervention Among Aged Community-residents in Zhejiang, China
This study is testing a lifestyle program that includes exercise, healthy eating, brain training, and managing health risks to see if it can help older adults in China avoid memory problems and dementia.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1200 (estimated) |
| Ages | 60 Years to 80 Years |
| Sex | All |
| Sponsor | Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT05886114 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of a multi-domain lifestyle intervention aimed at preventing cognitive decline and dementia among elderly residents in Zhejiang, China. The intervention includes physical activity, nutritional guidance, cognitive training, and management of vascular risk factors, and will be conducted over a two-year period with 1200 participants. Participants will be randomly assigned to either the intervention group or a control group receiving self-guided management. The study aims to assess both cognitive improvements and changes in brain structure and function resulting from the intervention.
Who should consider this trial
Good fit: Ideal candidates are elderly individuals aged 60-80 who are at risk of cognitive decline but do not have diagnosed dementia.
Not a fit: Patients with diagnosed dementia or major depression, as well as those with significant physical disabilities or severe sensory impairments, will not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could significantly slow cognitive decline and improve quality of life for at-risk elderly individuals.
How similar studies have performed: Previous studies have shown success with similar multi-domain interventions in other populations, suggesting potential for effectiveness in this demographic as well.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * At risk of cognitive decline: cognitive performance at the mean level or slightly lower than expected for age with no dementia (AD8\>=3 and/or 5-min MoCA \>, \< 11) * Free of physical disabilities that preclude participation in the study * Willing to complete all study-related activities for 24 months * Willing to be randomized to either lifestyle intervention group Exclusion Criteria: * Diagnosed dementia patients * Diagnosed major depression or other neuropsychological diseases * Malignant diseases * Symptomatic cardiovascular disease * Revascularization within one year * Severe loss of vision, hearing or communicative ability
Where this trial is running
Hangzhou, Zhejiang
- School of Public Health and The Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, China — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: Xin Xu, PhD
- Email: xuxinsummer@zju.edu.cn
- Phone: +8613575760802
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.