Multi-domain lifestyle intervention for older adults at risk of cognitive decline in China

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of a multi-domain lifestyle intervention aimed at preventing cognitive decline and dementia among elderly residents in Zhejiang, China. The intervention includes physical activity, nutritional guidance, cognitive training, and management of vascular risk factors, and will be conducted over a two-year period with 1200 participants. Participants will be randomly assigned to either the intervention group or a control group receiving self-guided management. The study aims to assess both cognitive improvements and changes in brain structure and function resulting from the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* At risk of cognitive decline: cognitive performance at the mean level or slightly lower than expected for age with no dementia (AD8\>=3 and/or 5-min MoCA \>, \< 11)
* Free of physical disabilities that preclude participation in the study
* Willing to complete all study-related activities for 24 months
* Willing to be randomized to either lifestyle intervention group

Exclusion Criteria:

* Diagnosed dementia patients
* Diagnosed major depression or other neuropsychological diseases
* Malignant diseases
* Symptomatic cardiovascular disease
* Revascularization within one year
* Severe loss of vision, hearing or communicative ability

Where it's running

• School of Public Health and The Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, China
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Xin Xu, PhD
• Email: xuxinsummer@zju.edu.cn
• Phone: +8613575760802

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.