Investigating the causes of bleeding in the brain related to amyloid buildup
Official title: Causes and Consequences of Leptomeningeal Bleeding in Cerebral Amyloid Angiopathy
Funded at Massachusetts General Hospital · NIH-10991800 · Data updated 2026-11-12
This study is looking at how a buildup of a protein in the brain's blood vessels can cause bleeding and other problems, especially in older adults, to help find better ways to prevent these issues for people with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $230,071 |
| NIH project number | 5K08NS131530-02 |
| Project ID | NIH-10991800 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly individuals diagnosed with cerebral amyloid angiopathy who are at risk for intracerebral hemorrhage.
✕Less likely to help
Patients without cerebral amyloid angiopathy or those who are not elderly may not benefit from this research.
What this research studies
This research focuses on understanding cerebral amyloid angiopathy (CAA), a condition where amyloid-β protein accumulates in the blood vessels of the brain, leading to bleeding and other complications, particularly in older adults. The study aims to explore how severe CAA and associated leptomeningeal bleeding contribute to brain hemorrhages. Using advanced imaging techniques and mouse models, researchers will examine the mechanisms behind these bleeding events and their effects on brain health. The goal is to uncover new insights that could lead to better prevention strategies for brain hemorrhages in patients with CAA.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for brain hemorrhages in elderly patients with cerebral amyloid angiopathy.
How similar studies have gone: While the specific focus on leptomeningeal bleeding in CAA is novel, related research has shown promising results in understanding amyloid-related brain conditions.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Kozberg, Mariel Gailey — Massachusetts General Hospital
- Study coordinator: Kozberg, Mariel Gailey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.