Understanding bleeding risks in people with factor XI deficiency
Interdisciplinary approach to elucidate modifiers of bleeding phenotype in factor XI deficiency
This study is looking into why some people with factor XI deficiency bleed more than others, and it aims to create better tests to help predict who might be at risk, so that treatments can be improved for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11089557 on NIH RePORTER |
What this research studies
This research investigates the reasons behind varying bleeding risks in individuals with factor XI deficiency, a genetic disorder affecting blood clotting. By analyzing blood samples from well-characterized patients, the study aims to develop specialized assays that can accurately predict who is at risk of excessive bleeding. The approach combines laboratory techniques and computational modeling to uncover the biological mechanisms influencing bleeding. Ultimately, the goal is to improve treatment strategies for both bleeding and thrombosis in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with factor XI deficiency, particularly those experiencing variable bleeding symptoms.
Not a fit: Patients with bleeding disorders unrelated to factor XI deficiency may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and management of bleeding risks for patients with factor XI deficiency.
How similar studies have performed: Previous research has shown promise in understanding bleeding risks in related conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Wolberg, Alisa S. — Univ of North Carolina Chapel Hill
- Study coordinator: Wolberg, Alisa S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.