Comparing blood thinners for patients on ECMO support

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study evaluates the effectiveness of three different anticoagulation strategies—unfractionated heparin, argatroban, and enoxaparin—during extracorporeal membrane oxygenation (ECMO) therapy. It is a randomized controlled trial designed to determine if enoxaparin or argatroban can provide similar outcomes to the standard treatment of unfractionated heparin in preventing thromboembolic events. The study will measure the incidence of these events in patients requiring ECMO support. Conducted at a single center, this phase IV study aims to improve anticoagulation management in critically ill patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* either

  * require ECMO support or
  * have been started on ECMO therapy within the last 12 hours

Exclusion Criteria:

* Patients exhibiting contraindications to anticoagulation in general or any of the three investigated substances
* Patients who are pregnant
* Patients suffering from a clinically relevant pre-existing coagulopathy
* Patients, for whom screening, randomization and implementation of study protocol cannot be initiated within 12 hours after cannulation
* Patients receiving ongoing therapeutic systemic anticoagulation prior to ECMO implantation, or exhibiting an indication for therapeutic anticoagulation (e.g., pulmonary embolism)
* Patients whose total duration of ECMO support lasts less than 24 hours
* Patients with start of ECMO support during CPR (eCPR)
* Patients with passive decarboxylation, without an active pumping system
* Patients, who have been weaned off ECMO support within the last 30 days
* Patients with central ECMO cannulation and/or after cardiopulmonary bypass

Where it's running

• Medical University of Vienna
  Vienna, State of Vienna, Austria Recruiting

Study contacts

• Principal investigator: Johannes Gratz, PD, MD, PhD — Medical Univeristy of Vienna
• Study coordinator: Vincenz Scharner, MD
• Email: vincenz.scharner@meduniwien.ac.at
• Phone: +43 1 40400

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using tranexamic acid to reduce bleeding in major colorectal surgery

  This study is testing if giving tranexamic acid before major colorectal surgery can help reduce bleeding during and after the operation for patients.

  Recruiting Phase 2 The Cleveland Clinic · Cleveland, Ohio · NCT06657924

• Antiplatelet-Only versus Antiplatelet plus Low-Dose Rivaroxaban after Heart Events

  In adults 65 or older with prior heart events and certain arterial diseases, this study tests whether continuing clopidogrel alone is no worse than adding low-dose rivaroxaban to aspirin-based therapy.

  Recruiting Phase 4 Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT07796217

• Bedside Spirometry to see if tidal volume matches ideal body weight in non-intubated ARDS

  This pilot study tests whether tidal volume measured at bedside with high-flow oxygen and after NIV settings can help classify ARDS patients who are not intubated.

  Recruiting Centre Hospitalier Departemental Vendee · La Roche-sur-Yon and 1 other locations · NCT07750717

• Early breathing therapy just one hour after CABG extubation

  This trial tests whether starting respiratory physiotherapy one hour after extubation improves recovery for adults after elective CABG compared with starting on the first postoperative day.

  Recruiting Alma Mater Europaea - Slovenia · Zagreb · NCT07730034

• Humidification methods in trauma ICU patients on mechanical ventilation

  This study tests whether active heated humidifiers or passive heat-and-moisture exchangers work better in trauma ICU patients who need long-term mechanical ventilation.

  Recruiting Assiut University · Asyut, Asyut Governorate · NCT07713238

• Turkish version of the S3-NIV questionnaire: testing its reliability for home NIV patients

  We’re testing whether the Turkish S3-NIV questionnaire reliably measures how well patients on home non-invasive ventilation can manage daily use and comfort.

  Recruiting Istanbul Saglik Bilimleri University · Istanbul · NCT07610122

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.