Bleeding risk from blood thinners in people with cancer
Prediction of Anticoagulant-Related Bleeding Risk in Patients with Cancer
This project will build a tool to predict how likely people with cancer are to have serious bleeding while taking blood thinners.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11237616 on NIH RePORTER |
What this research studies
You would be part of work to create a prediction tool that estimates your chance of a major bleed while on anticoagulant therapy. The team will use medical records and clinical trial data from people with cancer and blood clots, and examine factors like cancer type, treatments, and the specific blood thinner used. They will develop and then calibrate the model especially for cancer patients who are at high risk of clotting and are being considered for preventive therapy. The end product would be a calculator clinicians can use to help balance preventing clots against the risk of dangerous bleeding for each person.
Who could benefit from this research
Good fit: People with cancer who have had a venous blood clot (VTE) or who are being considered for anticoagulant therapy to prevent or treat clots are the ideal candidates.
Not a fit: People without cancer, those not taking anticoagulants, or patients whose bleeding risk is already clearly determined may not receive direct benefit from this work.
Why it matters
Potential benefit: If successful, this could help doctors personalize blood-thinner use to reduce dangerous bleeds while still preventing clots.
How similar studies have performed: Bleeding-risk models exist and perform in non-cancer populations, and recent trials support some direct oral anticoagulants in cancer, but a validated cancer-specific bleeding prediction tool is novel and untested.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Sanfilippo, Kristen Marie — Washington University
- Study coordinator: Sanfilippo, Kristen Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.