Understanding joint bleeding in people with hemophilia
Official title: Exploring the Biomechanics of Joint Bleeding in Persons with Hemophilia to Better
Funded at University of Colorado Denver · NIH-11005040 · Data updated 2026-11-12
This study looks at how bleeding in the joints affects how people with hemophilia move, using special technology to measure their movements, so we can help them make safer choices for staying active and reduce the chances of future bleeding.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | February 19, 2021 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $160,470 |
| NIH project number | 5K23HL151886-05 |
| Project ID | NIH-11005040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with hemophilia who experience joint bleeding.
✕Less likely to help
Patients without a diagnosis of hemophilia or those who do not experience joint bleeding may not benefit from this research.
What this research studies
This research investigates how joint bleeding affects movement and biomechanics in individuals with hemophilia. By using advanced motion capture and force plate technology, the study aims to objectively measure the forces involved in lower extremity joint and muscle bleeding. The goal is to better understand the relationship between past joint bleeding and current movement patterns, which could help inform safer physical activity choices for patients. Ultimately, this research seeks to reduce the risk of future bleeding episodes.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing joint bleeding and enhancing the quality of life for individuals with hemophilia.
How similar studies have gone: Previous research has shown promise in understanding biomechanics related to bleeding disorders, but this specific approach is relatively novel.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Warren, Beth Boulden — University of Colorado Denver
- Study coordinator: Warren, Beth Boulden
Related research
Other NIH-funded projects on the same topics.
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Investigating bleeding risks in women who are carriers of Hemophilia A
This study is looking at why some women who carry Hemophilia A experience unusual bleeding, even when their blood tests seem normal, and it aims to create a tool to help predict their bleeding risk so they can get better care.
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Direct measurement of RhD sensitization after early-pregnancy bleeding
This study tests how often Rh immunoglobulin given after bleeding in early pregnancy prevents RhD sensitization in pregnant people.
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A safer, longer-lasting gene delivery approach for Hemophilia A using improved nonviral vectors
Researchers are testing a new type of nonviral gene delivery that could provide longer expression of a therapeutic gene for adults with Hemophilia A.
-
EpiMAX: a new injectable gel that stops GI bleeding quickly and for days
A new injectable hydrogel with epinephrine-loaded microparticles is designed to plug GI bleeds and provide immediate and lasting hemostasis for about 72 hours.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.