Anti-microbial platelet-like particles to stop bleeding and boost healing
Official title: Anti-microbial platelet-like-particles to treat internal bleeding and augment subsequent healing
Funded at North Carolina State University Raleigh · NIH-11310844 · Data updated 2026-11-12
A new platelet-like particle treatment is being developed to quickly stop bleeding after trauma and help wounds heal better, especially in severe injuries and brain injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $584,108 |
| NIH project number | 5R01HL162809-04 |
| Project ID | NIH-11310844 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with traumatic injuries at risk of significant bleeding or those with conditions like arterial injury where improved hemostasis could impact recovery.
✕Less likely to help
Patients with injuries not at risk of heavy bleeding or those for whom the therapy is not applicable might not benefit.
What this research studies
This project aims to use specially engineered platelet-like particles that target the wound site and help form a stable clot while promoting healing. The approach combines deformable microgels with wound-targeting features to bind fibrin and support clot contraction. By focusing on rapid hemostasis and improved tissue repair, the research seeks to reduce infections and complications after traumatic injuries. The work involves preclinical studies to understand how these particles behave in bleeding scenarios and how they influence healing outcomes.
Why it matters
Potential benefit: If successful, this could lead to faster stopping of bleeding after injuries and better recovery of tissues, potentially reducing complications and death from trauma.
How similar studies have gone: Prior work with platelet-like particles and wound-targeting materials suggests potential for improved hemostasis and healing, but this specific approach is novel and exploratory.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Brown, Ashley Carson — North Carolina State University Raleigh
- Study coordinator: Brown, Ashley Carson
Related research
Other NIH-funded projects on the same topics.
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A new RNA treatment delivered in lipids aims to slow down fibrinolysis and lessen bleeding for people with bleeding disorders or severe hemorrhage.
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Thrombosis and Bleeding Risk in Medical Inpatients
A patient-facing program to better predict who is at risk for blood clots or bleeding during and after hospital stays, and to tailor prevention accordingly.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.