Bleeding and Platelet Problems in Ehlers-Danlos Syndrome
Official title: Platelet function abnormalities underlying bleeding in a connective tissue disorder the Ehlers Danlos syndrome
Funded at University of Iowa · NIH-11401685 · Data updated 2026-11-12
This NIH grant looks at why people with Ehlers-Danlos syndrome bleed more and how platelet function is involved, with goals that could lead to better care during surgery or emergencies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | September 1, 2025 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $636,909 |
| NIH project number | 5R01HL174419-02 |
| Project ID | NIH-11401685 on NIH RePORTER |
Who could benefit from this research
✓Could help
People diagnosed with Ehlers-Danlos syndrome who experience bleeding or are at risk of bleeding during procedures.
✕Less likely to help
Patients without EDS or without bleeding concerns may not directly benefit from this study.
What this research studies
People with EDS often have dangerous bleeding, especially during surgeries or dental work. The research will use samples from patients and a mouse model to study how platelets work differently in EDS and how this affects bleeding risk. The team will explore the biology of platelet function, including how signals and receptors contribute to clotting, with the aim of finding targets to prevent bleeding. By understanding these mechanisms, clinicians may be able to develop better guidelines and treatments for EDS-related bleeding in the future.
Why it matters
Potential benefit: If successful, the work could lead to new strategies to prevent or reduce bleeding in people with EDS.
How similar studies have gone: Previous work has shown platelet abnormalities in EDS, but this project aims to connect these findings to bleeding risk in detail.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Chauhan, Anil Kumar — University of Iowa
- Study coordinator: Chauhan, Anil Kumar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.