Sprayable hydrogel sealant to prevent gut bleeding
Production of a Hydrogel-based Mucosal Sealant for Gastrointestinal Bleeding Prevention
This project is developing a sprayable, biodegradable glue doctors could use during endoscopy to seal mucosal wounds and lower the chance of bleeding after procedures like polyp removal.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Biodevek INC NIH-funded |
| Lab location | 1 site (Cambridge, UNITED STATES) |
| Project ID | NIH-11092336 on NIH RePORTER |
What this research studies
If you need an endoscopic procedure, this team is creating GastroShield, a sprayable gel that sticks to the wet lining of your gut to cover and protect small wounds. The gel is made from biodegradable polymers that cross-link to form a strong seal intended to last longer than clips or powder products. Researchers have optimized the formula for better adhesion and plan laboratory and animal testing now, with the goal of moving to clinical testing at hospitals later. It is designed to be quick and easier for doctors to apply so it could reduce bleeding without relying on complex clipping skills.
Who could benefit from this research
Good fit: People undergoing endoscopic procedures that create mucosal wounds (for example polypectomy) who are at risk for delayed gastrointestinal bleeding would be the most likely candidates.
Not a fit: Those with active massive GI bleeding needing immediate surgery, or people with known allergy to the product materials, are unlikely to benefit from this sealant.
Why it matters
Potential benefit: Could reduce delayed bleeding after endoscopic procedures, lowering hospital stays, repeat interventions, and the need for blood transfusions.
How similar studies have performed: Traditional clips and powder hemostats have long been used but have clear limits, and sprayable adhesive approaches for GI mucosa are relatively new with promising early lab and animal data but limited clinical proof so far.
Where this research is happening
Cambridge, UNITED STATES
- Biodevek INC — Cambridge, United States (Active)
Researchers
- Principal investigator: Munoz Taboada, Gonzalo — Biodevek INC
- Study coordinator: Munoz Taboada, Gonzalo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.