Investigating bleeding risks in women who are carriers of Hemophilia A
Abnormal Bleeding Risk in Female Hemophilia A Carriers
This study is looking at why some women who carry Hemophilia A experience unusual bleeding, even when their blood tests seem normal, and it aims to create a tool to help predict their bleeding risk so they can get better care.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-10907656 on NIH RePORTER |
What this research studies
This research focuses on understanding the bleeding tendencies in female carriers of Hemophilia A, a condition often overlooked in women. The study aims to develop a risk prediction model that identifies factors contributing to bleeding in these carriers, who may experience significant bleeding events despite having normal Factor VIII levels. By utilizing innovative methodologies beyond standard coagulation tests, the research seeks to provide a clearer understanding of how genetic factors, such as X-chromosome inactivation, influence bleeding risk. This could lead to improved management and classification of female Hemophilia A carriers.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult women who are carriers of Hemophilia A and may experience abnormal bleeding.
Not a fit: Patients who are not carriers of Hemophilia A or who do not experience bleeding symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification and management of bleeding risks in female Hemophilia A carriers, improving their quality of life.
How similar studies have performed: While research on Hemophilia A has been extensive, the specific focus on female carriers and their bleeding risks is relatively novel and underexplored.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Cygan, Peter H — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Cygan, Peter H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.