Investigating bleeding risks in women who are carriers of Hemophilia A
Official title: Abnormal Bleeding Risk in Female Hemophilia A Carriers
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-10907656 · Data updated 2026-11-12
This study is looking at why some women who carry Hemophilia A experience unusual bleeding, even when their blood tests seem normal, and it aims to create a tool to help predict their bleeding risk so they can get better care.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $172,670 |
| NIH project number | 5K08HL159314-04 |
| Project ID | NIH-10907656 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adult women who are carriers of Hemophilia A and may experience abnormal bleeding.
✕Less likely to help
Patients who are not carriers of Hemophilia A or who do not experience bleeding symptoms may not benefit from this research.
What this research studies
This research focuses on understanding the bleeding tendencies in female carriers of Hemophilia A, a condition often overlooked in women. The study aims to develop a risk prediction model that identifies factors contributing to bleeding in these carriers, who may experience significant bleeding events despite having normal Factor VIII levels. By utilizing innovative methodologies beyond standard coagulation tests, the research seeks to provide a clearer understanding of how genetic factors, such as X-chromosome inactivation, influence bleeding risk. This could lead to improved management and classification of female Hemophilia A carriers.
Why it matters
Potential benefit: If successful, this research could lead to better identification and management of bleeding risks in female Hemophilia A carriers, improving their quality of life.
How similar studies have gone: While research on Hemophilia A has been extensive, the specific focus on female carriers and their bleeding risks is relatively novel and underexplored.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Cygan, Peter H — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Cygan, Peter H
Related research
Other NIH-funded projects on the same topics.
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cGMP production of FVIII-making placental cells to help people with Hemophilia A
A new, patient-friendly therapy aims to make FVIII-producing placental cells in the lab to help adults with Hemophilia A, potentially offering a longer-lasting and more affordable treatment.
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A safer, longer-lasting gene delivery approach for Hemophilia A using improved nonviral vectors
Researchers are testing a new type of nonviral gene delivery that could provide longer expression of a therapeutic gene for adults with Hemophilia A.
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Hemophilia A: studying why some people develop inhibitors to FVIII across families
This NIH grant funds a multi-year program to follow families affected by severe hemophilia A to understand why some individuals develop antibodies against factor VIII.
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Intraosseous delivery of gene therapy vectors for hemophilia A
A gene therapy approach using vectors delivered into bone to help people with hemophilia A reduce or eliminate the need for frequent FVIII treatments.
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Targeting FVIII production to eye-opening blood vessels in hemophilia A
Aims to improve treatment for people with hemophilia A by directing how the body makes clotting factor VIII, using a targeted gene-delivery approach.
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Platelet-targeted FVIII Gene Therapy for Hemophilia A
A gene therapy approach aims to make platelets carry FVIII to help people with hemophilia A, even if they have inhibitors against FVIII.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.