Investigating how aging affects bleeding risk in von Willebrand disease
Official title: The Von Willebrand Disease Aging and Bleeding Correlation (VWD ABC) Study
Funded at University of Pittsburgh at Pittsburgh · NIH-10877727 · Data updated 2026-11-12
This study is looking at how age affects bleeding risk in adults with von Willebrand disease, and it aims to help improve care for people living with this condition by understanding their bleeding tendencies better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | July 15, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $171,815 |
| NIH project number | 5K23HL148762-05 |
| Project ID | NIH-10877727 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 18 and older diagnosed with type 1 von Willebrand disease.
✕Less likely to help
Patients with bleeding disorders other than von Willebrand disease or those under 18 years old may not benefit from this research.
What this research studies
This research focuses on understanding the relationship between age and bleeding risk in patients with von Willebrand disease (VWD), a hereditary bleeding disorder. The study will enroll adults aged 18 and older from multiple Hemophilia Treatment Centers, where participants will undergo assessments using a bleeding evaluation tool and provide blood samples for laboratory analysis. The goal is to determine how age influences von Willebrand factor levels and bleeding tendencies, which could lead to improved management strategies for patients with VWD.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of bleeding risks in older patients with von Willebrand disease.
How similar studies have gone: Previous research has shown promising results in understanding bleeding disorders, but this specific focus on aging in von Willebrand disease is relatively novel.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Seaman, Craig D — University of Pittsburgh at Pittsburgh
- Study coordinator: Seaman, Craig D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.