Investigating the role of tissue factor in bleeding and clotting risks
Official title: Functional genetics of tissue factor in bleeding and thrombotic risk
Funded at Beth Israel Deaconess Medical Center · NIH-10695220 · Data updated 2026-11-12
This study is looking at how a protein called tissue factor affects bleeding and clotting problems, and it's for people who have conditions like heart attacks or strokes, with the goal of finding better ways to understand and manage these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 16, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $437,500 |
| NIH project number | 5DP5OD028129-05 |
| Project ID | NIH-10695220 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of bleeding disorders or thrombotic events.
✕Less likely to help
Patients without any genetic predisposition to bleeding or thrombotic disorders may not benefit from this research.
What this research studies
This research focuses on understanding how tissue factor (TF), a key player in blood coagulation, contributes to bleeding and thrombotic disorders. By using advanced techniques such as CRISPR to edit stem cells and studying genetic factors in families with bleeding disorders, the researchers aim to uncover the genetic modifiers that influence TF activity. This could lead to better understanding and management of conditions like myocardial infarction, stroke, and venous thromboembolism. The study combines functional genetics with human genetic approaches to explore the heritability of these disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for patients at risk of bleeding and thrombotic events.
How similar studies have gone: Previous research has shown promise in understanding genetic factors influencing coagulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Schulman, Sol — Beth Israel Deaconess Medical Center
- Study coordinator: Schulman, Sol
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.