Clinical trial Recruiting at 1 site Observational Ages 14 to 40

Using Tranexamic Acid to Reduce Bleeding During Wisdom Tooth Removal

Official title: Investigation of the Effects of Tranexamic Acid Solution Irrigation on Bleeding, Surgical Field Visibility, and Postoperative Edema in the Extraction of Horizontally Impacted Third Molars

Run by Bezmialem Vakif University · NCT06806241 · Data updated 2026-11-12

This study is testing if using tranexamic acid during wisdom tooth removal can help reduce bleeding and swelling for healthy patients who need their impacted teeth taken out.

Quick facts

Study typeObservational
Ages14 Years to 40 Years
SexAll
Enrollment20 (estimated)
SponsorBezmialem Vakif University
Academic / other
Locations1 site (Istanbul, Fatih)
StatusRecruiting
StartedJanuary 1, 2025
Main results expectedMarch 1, 2026
Study endsMarch 10, 2026
Registry record updatedJune 24, 2025
Trial IDNCT06806241 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are systemically healthy individuals aged 14-40 years who require the extraction of bilaterally impacted third molars.

Probably not a fit

Patients with systemic diseases, bleeding disorders, or advanced infections associated with the impacted tooth may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of tranexamic acid (TXA) irrigation during the surgical extraction of impacted third molars to assess its effectiveness in reducing intraoperative blood loss and postoperative edema. TXA is a hemostatic agent that can be applied topically to minimize systemic absorption and potential side effects. The study will involve patients who are systemically healthy and require the extraction of bilaterally impacted third molars with bone retention. By comparing outcomes with and without TXA irrigation, the study aims to provide insights into its safety and efficacy in dental surgery.

Why it matters

Potential benefit: If successful, this approach could significantly reduce bleeding and improve recovery outcomes for patients undergoing wisdom tooth extraction.

How similar studies have gone: Previous studies have shown success with TXA in other surgical contexts, but its application in dental extractions is novel and untested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Indicated for the Extraction of Bilaterally Impacted Third Molars with Bone Retention.
2. Systemically healthy patients aged 14-40 years with no bleeding disorders.

Exclusion Criteria:

1. Patients with systemic diseases affecting general health.
2. Patients diagnosed with any bleeding disorder.
3. Patients with advanced infection or cysts associated with the impacted tooth.

Where it's running

  • Bezmialem Vakıf Universty
    Istanbul, Fatih, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.