Understanding bleeding issues in acute promyelocytic leukemia
Official title: Mechanisms of coagulopathy and bleeding in acute promyelocytic leukemia
Funded at Univ of North Carolina Chapel Hill · NIH-11175769 · Data updated 2026-11-12
This study is looking into why people with acute promyelocytic leukemia often have serious bleeding problems, using special mouse models to help understand the blood issues they face, with the hope of finding better ways to help patients manage these complications.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $764,817 |
| NIH project number | 1R56HL171301-01A1 |
| Project ID | NIH-11175769 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with acute promyelocytic leukemia who are at risk of bleeding complications.
✕Less likely to help
Patients with other types of leukemia or those who do not have bleeding complications may not benefit from this research.
What this research studies
This research investigates the mechanisms behind bleeding complications in patients with acute promyelocytic leukemia (APL), a type of acute myeloid leukemia. The study utilizes newly developed mouse models that mimic the hemostatic problems seen in APL patients, focusing on factors like thrombocytopenia and coagulation activation. By examining the role of specific proteins and complexes in the blood, the research aims to uncover why severe bleeding occurs, particularly in the early stages of the disease. The findings could lead to improved management strategies for patients experiencing these life-threatening complications.
Why it matters
Potential benefit: If successful, this research could lead to better treatments that reduce the risk of severe bleeding in APL patients, potentially saving lives.
How similar studies have gone: Previous studies have shown promising results in understanding bleeding mechanisms in other types of leukemia, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Hisada, Yohei M — Univ of North Carolina Chapel Hill
- Study coordinator: Hisada, Yohei M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.