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Clinical trials and research at Second Affiliated Hospital, Zhejiang University, School of Medicine

• 284Clinical trials
• 2New in 30 days
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Newest trials

All recruiting trials (newest 150 of 284)

• Intelligent Video Laryngoscope to Help Emergency Intubations

  A smart video laryngoscope with AI is tested to help doctors place tubes in critically ill adults needing emergency intubation.

  Recruiting at 2 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 1 other locations · NCT07922044

• Understanding anxiety, depression, and bipolar disorder over time in China

  This study tests how anxiety, depressive, and bipolar symptoms change over three years to find patterns that help with earlier recognition and prediction in people aged 12–55.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07903246

• Ultrasound-guided nasal bone fracture reduction

  This study tests whether using ultrasound to guide nasal bone fracture reduction can improve accuracy and outcomes for people with recent nasal injuries.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 1 other locations · NCT07869563

• Simplified Tranexamic Acid Regimen for Trauma with Hemorrhage

  This trial tests a simplified TXA dosing approach to see if it safely helps adults with major trauma and significant bleeding.

  Recruiting at 3 sites Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 2 other locations · NCT07869537

• Retrobulbar glucocorticoid injection for retinal light injury

  This study tests whether giving a retrobulbar glucocorticoid injection helps people who have retinal damage from bright light.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07869511

• Bevacizumab for severe HHT-related nosebleeds

  This study tests whether bevacizumab can help people with hereditary hemorrhagic telangiectasia who have severe nosebleeds.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07828015

• Hyperfractionated radiotherapy for high-proliferation NSCLC

  This trial tests whether a boosted, accelerated radiotherapy approach is safe and helps people with highly proliferative non-small cell lung cancer.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07823855

• Memory-Enhanced CAR-T Therapy for Relapsed/Refractory Large B-Cell Lymphoma

  This trial tests memory-enhanced 7×19-THEMIS CAR-T cells in adults with relapsed or refractory large B-cell lymphoma to see how safe they are and whether tumors shrink or disappear.

  Recruiting Phase 1/2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07788118

• Radiotherapy Approach for Poorly Differentiated Early Glottic Cancer

  This trial tests whether definitive radiotherapy or postoperative radiotherapy can improve local control for adults with poorly differentiated early-stage glottic squamous cell carcinoma.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07781098

• Postoperative IMRT to reduce recurrence in early glottic cancer involving the anterior commissure

  This trial tests whether adding postoperative IMRT after surgery for early-stage glottic cancer with anterior commissure involvement can lower local recurrence.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07781085

• Sintilimab Plus Hypofractionated Radiotherapy Then Chemoradiotherapy for Locally Advanced Head and Neck Cancer

  This study tests whether giving sintilimab with a short, high-dose radiotherapy course followed by standard chemoradiotherapy helps people with locally advanced head and neck squamous cell carcinoma.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07781072

• taVNS Therapy for Social Anxiety Disorder

  This study tests whether non-invasive taVNS can help reduce social anxiety symptoms in adults with SAD.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 1 other locations · NCT07772401

• AI-assisted and traditional workflows for admission diagnosis and management planning

  This trial tests whether an AI-agent workflow helps doctors make better admission diagnoses and care plans on simulated cases, compared with plain AI-assisted and traditional workflows.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07760051

• Protective effect of phycocyanin on liver injury after partial hepatectomy

  This study tests whether taking phycocyanin around liver surgery can reduce liver injury and help the liver recover in adults with intrahepatic cholangiocarcinoma.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07760038

• Remimazolam versus Midazolam for anesthesia induction in older adults

  This observational study compares remimazolam and midazolam when inducing anesthesia in people aged 65 and older undergoing elective non-cardiac surgery to see which provides better stability and safety.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07746505

• Amivantamab with intrathecal pemetrexed for leptomeningeal metastasis from EGFR-mutated lung adenocarcinoma

  This study tests whether giving amivantamab with intrathecal pemetrexed is safe and may help treat leptomeningeal metastasis in adults with EGFR-mutant lung cancer.

  Recruiting Phase 1/2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07744529

• TEER plus electrical cardioversion for severe mitral regurgitation with atrial fibrillation

  This study tests whether adding electrical cardioversion to TEER helps people with severe mitral regurgitation and atrial fibrillation to have fewer deaths, hospitalizations for heart failure, and strokes within a year.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07741383

• Auricular point stimulation with dexamethasone vs standard antiemetics for chemo-induced nausea in pancreatic cancer

  This study tests whether adding ear acupuncture-style stimulation to dexamethasone can prevent and reduce nausea and vomiting caused by gemcitabine plus paclitaxel in pancreatic cancer patients, compared with the usual antiemetic drugs.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07716228

• Auricular point stimulation with dexamethasone versus standard antiemetics for nausea from trastuzumab deruxtecan

  This trial tests whether adding ear acupuncture-style stimulation to dexamethasone can prevent and reduce nausea and vomiting caused by trastuzumab deruxtecan in breast cancer patients, compared with the usual antiemetic regimen.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07716189

• Auricular Point Stimulation With Dexamethasone vs Standard Anti-nausea Medications for Docetaxel‑Cyclophosphamide Therapy

  This study tests whether adding ear acupuncture-like stimulation to dexamethasone can match or be as effective as standard antiemetic drugs for preventing nausea and vomiting in people receiving the docetaxel–cyclophosphamide chemotherapy.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07716176

• tRF-31 and HIPK2 in age-related cataract: a look at eye tissue and surgery outcomes

  This observational study tests whether the tRF-31/HIPK2 signaling axis in the eye relates to cataract severity in adults with age-related cataract.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07672899

• Intensified adjuvant therapy for high-risk glioblastoma after partial removal or early progression

  This study tests whether adding intensified post-surgery treatment helps adults with high-risk glioblastoma live longer without the disease progressing.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07670026

• SKB264 plus Glecirasib in KRAS G12C-mutant NSCLC: first-line phase 2 approach

  This phase II study tests whether the drug combination SKB264 and Glecirasib can help people with KRAS G12C-mutant NSCLC as a first-line treatment.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07670013

• Prospective cardiac surgery cohort to improve perioperative care

  A multi-center study will test a large, forward-looking database of adults undergoing heart surgery to better understand what affects short- and long-term outcomes.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07662317

• CT-FFR in Chronic Coronary Syndrome: A multicenter look at risk and outcomes

  This study tests whether CT-derived fractional flow reserve (CT-FFR) from prior CT scans can help predict 1-year major adverse cardiovascular events in adults with chronic coronary syndrome.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07659119

• Spinal cord stimulation to help arm and leg movement after stroke

  This study tests whether a spinal cord stimulator can improve arm and leg movement in adults who had a stroke and still have weak limbs after at least 6 months.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07627516

• Multimodal Cardiac MRI to See How the Heart Is Working

  This study tests a comprehensive MRI approach to characterize heart structure and tissue in adults with suspected or confirmed cardiovascular disease.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07617844

• Preventing nausea and vomiting during multi-cycle chemo and immunotherapy in esophageal and lung cancer

  This study tests a combination antiemetic with dexamethasone to see if it lowers nausea and vomiting in adults with esophageal or lung cancer receiving several cycles of chemo plus immunotherapy.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07617246

• Culmerciclib plus aromatase inhibitors for early ER-positive/HER2-negative breast cancer

  This study tests whether adding culmerciclib to endocrine therapy before surgery helps highly proliferative ER-positive/HER2-negative breast cancer patients see a better response.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07616453

• Focused ultrasound-guided targeted drug delivery with neoadjuvant therapy for HER2-positive breast cancer

  This study tests a focused ultrasound–driven drug delivery approach added to neoadjuvant therapy for women with HER2-positive breast cancer to see if it’s feasible, safe, and shows early signs of effectiveness.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07616440

• Fovinaciclib with endocrine therapy and HER2 blockade for HR+/HER2+ early breast cancer

  This study tests whether adding fovinaciclib to endocrine therapy and dual HER2 blockade can shrink HR+/HER2+ breast tumors before surgery, with treatment adapted after an early response.

  Recruiting at 3 sites Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Nanjing, Jiangsu and 2 other locations · NCT07616427

• Rectosigmoid Lesion Excision vs. Resection in Advanced Ovarian Cancer

  This study tests whether removing a rectosigmoid lesion without full bowel resection can be as safe as removing the bowel segment in women with advanced ovarian cancer.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07616310

• Finerenone in patients having TAVI with heart failure

  This study tests whether finerenone can help people with heart failure and preserved ejection fraction who are undergoing transcatheter aortic valve implantation.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Bengbu, Anhui and 60 other locations · NCT07575672

• Photon-counting CT for detecting subsegmental pulmonary embolism

  This study will see if photon-counting CT finds very small pulmonary emboli more accurately than standard dual-source CT in adults with suspected acute pulmonary embolism.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07575503

• Ear acupressure plus dexamethasone to prevent chemo nausea from docetaxel and cyclophosphamide

  This trial will test whether ear acupressure (auricular point stimulation) combined with dexamethasone can prevent or reduce nausea and vomiting in adults receiving docetaxel plus cyclophosphamide after breast cancer surgery.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07537699

• Ear acupressure plus dexamethasone to prevent nausea and vomiting from trastuzumab deruxtecan

  This trial will try ear acupressure combined with a standard dose of dexamethasone to prevent or reduce nausea and vomiting in breast cancer patients receiving trastuzumab deruxtecan.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07537673

• Ear acupressure plus dexamethasone to prevent nausea and vomiting during gemcitabine and albumin‑bound paclitaxel treatment for pancreatic cancer

  This will see if ear acupressure with bean seeds plus an IV dose of dexamethasone can prevent nausea and vomiting in people with pancreatic cancer receiving gemcitabine combined with albumin‑bound paclitaxel.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07537660

• Higher-dose, less-frequent guselkumab versus the usual dose for moderate-to-severe plaque psoriasis in Chinese adults

  This will test whether a higher dose given less often of guselkumab works as well and is as safe as the usual dosing for Chinese adults with moderate-to-severe plaque psoriasis.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07532486

• Butylphthalide for Multiple System Atrophy: tests safety and symptoms

  This study tests whether 3-n-butylphthalide capsules can help reduce symptoms in people with multiple system atrophy compared with a placebo.

  Recruiting at 4 sites Phase 2/3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Nanning, Guangxi and 6 other locations · NCT07518810

• Second infusion of FAP-targeted iCDC for end-stage dilated cardiomyopathy

  This study tests whether a second dose of FAP-targeted immunosuppressive CAR-DC therapy can safely improve heart function in adults with end-stage dilated cardiomyopathy who previously had a partial response.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang / 浙江 · NCT07516288

• Preventive intrathecal thiotepa with standard chemoradiation for high‑risk glioblastoma

  This trial tests whether adding six weekly intrathecal injections of thiotepa to standard chemoradiation can lower leptomeningeal spread and improve outcomes for adults with newly diagnosed GBM that contacts the subventricular zone or had ventricular entry during surgery.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07511725

• Brain activation during mirror-hand movements after stroke (fNIRS)

  This project uses near-infrared sensors to see if moving the healthy hand while viewing its mirror image changes brain activity in people who had a first stroke within six months and have very weak finger movement.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07509944

• Digital system to detect and prevent disability risk in older adults

  This project will test a smartphone-enabled system that looks for early signs of disability and offers tailored prevention and management for people aged 65 and older.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07508813

• Safety and better outcomes with FAP-targeted immunosuppressive dendritic cells in ischemic heart failure

  This trial tests whether a patient's own FAP-targeted immunosuppressive dendritic cells can be safely given alongside standard care to help people with ischemic cardiomyopathy.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang / 浙江 · NCT07505199

• Camrelizumab, chemotherapy and Ivarmacitinib before surgery for resectable esophageal squamous cell carcinoma

  This trial tests whether giving camrelizumab with chemotherapy and the JAK inhibitor Ivarmacitinib before surgery can improve outcomes for patients with locally advanced esophageal squamous cell carcinoma that can be removed by operation.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, China · NCT07505186

• Personalized T-cell Therapy iNeo-Vac-T01 for Advanced Colorectal Cancer

  This will test a personalized T-cell therapy called iNeo-Vac-T01 in adults with advanced or metastatic colorectal cancer who have not responded to standard treatments.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07504523

• Preoperative spatially fractionated radiation for large limb and trunk soft tissue sarcoma

  This trial tests whether a short, five-fraction course of spatially fractionated radiation given before surgery helps adults with large (≥5 cm) limb or trunk soft tissue sarcoma stay disease-free longer.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07501026

• Tracking recovery after arthroscopic shoulder and knee surgeries

  This will follow people having routine arthroscopic shoulder or knee surgery to see if patient characteristics, tear details, or surgical choices predict better recovery and function over two years.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07501013

• Guselkumab for adults with Crohn's disease after ustekinumab failure

  This study will try guselkumab for adults with moderate to severe Crohn's disease who did not respond to or could not tolerate ustekinumab to see if they reach remission after 52 weeks.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07487480

• Guselkumab plus a JAK inhibitor for difficult-to-treat inflammatory bowel disease

  This project will try guselkumab together with a JAK inhibitor in people aged 14–80 whose moderate-to-severe inflammatory bowel disease has not responded to multiple other treatments.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07487311

• Single-cell and spatial mapping of cells in gum tissue from aggressive versus chronic periodontitis

  This project tests whether single-cell and spatial transcriptomics plus whole-genome sequencing can find cellular and genetic differences in gum tissue from people with aggressive periodontitis compared with chronic periodontitis and healthy gums.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07487272

• Autologous stem cell transplant with TEAM conditioning for lymphoma at high risk of CNS relapse

  This trial tests whether high-dose TEAM chemotherapy followed by an autologous stem cell transplant helps adults with non-Hodgkin lymphoma who are at high risk of the cancer returning in the brain or spinal cord.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07481669

• 7T MRI and visual perception markers for severe mood and psychotic disorders

  This project tests whether 7‑tesla MRI scans combined with visual perception tests can identify brain markers linked to diagnosis and treatment outcomes in adults with major depressive disorder, bipolar disorder, or schizophrenia.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07479758

• Preoperative ultrasound-guided nerve blocks to reduce pain and help recovery after ankle arthroscopy

  This randomized, double-blind trial will test whether preoperative ultrasound-guided popliteal sciatic and saphenous nerve blocks reduce early pain and opioid use and how they affect ankle strength and walking after ankle arthroscopy.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07470021

• Short bursts of noninvasive brain stimulation to the prefrontal cortex for social anxiety

  This treatment will test whether daily intermittent theta-burst brain stimulation to the prefrontal cortex can reduce social anxiety symptoms in people with SAD while tracking brain changes with EEG.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07466277

• AI-guided PET/CT method to identify lung cancer subtype and EGFR mutation status

  This project uses PET/CT scans and clinical information to try to identify lung cancer subtypes and whether the EGFR gene is mutated in adults with newly diagnosed lung cancer.

  Recruiting at 9 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Guangzhou, Guangdong and 8 other locations · NCT07463300

• Decoding Mandarin speech features from brain-surface signals

  This project will try to decode imagined Mandarin speech, including lexical tones, from high-density brain-surface (ECoG) signals in adult patients who are having clinically indicated cortical electrode placement.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07460037

• Short-course SBRT plus toripalimab and chemotherapy for chemo-resistant triple-negative breast cancer

  This trial will try a short, high-precision course of breast radiation followed by toripalimab with paclitaxel and carboplatin for people whose triple-negative breast cancer did not shrink after initial chemotherapy to see if it can eliminate invasive cancer at surgery.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07457359

• Emactinib sulfate with chemotherapy and adebrelimab given before surgery for advanced head and neck cancer

  This trial tests whether giving emactinib plus adebrelimab with nab‑paclitaxel and cisplatin before surgery can shrink tumors or increase complete responses in people with locally advanced head and neck squamous cell carcinoma.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07457346

• J-VALVE versus surgical aortic valve replacement for severe aortic regurgitation

  This study will test whether the J‑VALVE transfemoral valve works as well and is as safe as surgical aortic valve replacement in people aged 65 and older with severe native aortic regurgitation.

  Recruiting at 2 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Hefei, Anhui and 27 other locations · NCT07453407

• AI-assisted screening for heart valve disease using routine non-contrast chest CT

  This will test whether an AI program can spot moderate-to-severe heart valve disease on routine non-contrast chest CT scans in adults.

  Recruiting at 3 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Wuhan, Hubei and 2 other locations · NCT07449130

• Iparomlimab and Tuvonralimab with short-course radiotherapy and chemotherapy for locally advanced head and neck cancer

  This trial will test whether adding the dual PD-1/CTLA-4 antibody Iparomlimab–Tuvonralimab to hypofractionated radiotherapy and chemotherapy helps people with locoregionally advanced head and neck squamous cell carcinoma.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07447570

• Guselkumab vs Ustekinumab for stricturing Crohn's disease

  This study will follow adults with moderate-to-severe Crohn's disease and confirmed intestinal strictures to see if treatment with guselkumab or ustekinumab better controls obstructive symptoms and disease activity.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07444060

• TACE with sintilimab, bevacizumab, and ipilimumab N01 for advanced liver cancer

  This trial tries a combination of TACE with sintilimab and bevacizumab plus a single dose of ipilimumab N01 given at different times to see if it is safe and helps people with advanced hepatocellular carcinoma whose tumors cannot be removed.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07422753

• Predicting post-surgery treatment for liver cancer using AI and whole-slide images

  Aims to see if an AI model based on postoperative tissue images and imaging data can help decide if patients with hepatocellular carcinoma should receive adjuvant therapy after surgery.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07417800

• Gluteal versus ultrasound-guided corticosteroid injections for frozen shoulder

  This test will see if a buttock (gluteal) injection of compound betamethasone works as well as an ultrasound-guided steroid injection into the shoulder joint for adults 18–65 with frozen shoulder.

  Recruiting at 6 sites Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Shanghai, Shanghai Municipality and 9 other locations · NCT07416916

• Effects of linear accelerator X-rays on red blood cells collected during cancer surgery

  This project will test whether X-rays from a linear accelerator change the structure and function of red blood cells collected from adults undergoing cancer surgery.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07416045

• Radiotherapy after surgery for early-stage tongue cancer with high-risk features

  This trial tests whether giving radiotherapy after surgery helps people with early-stage tongue squamous cell carcinoma who have certain high-risk features stay cancer-free longer than simple follow-up.

  Recruiting at 2 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Bengbu, Anhui and 27 other locations · NCT07402525

• Oncolytic vaccinia virus delivering CD19 to create CAR‑T therapy inside the body for relapsed/refractory B‑cell lymphoma

  This treatment uses an oncolytic vaccinia virus that delivers a CD19 CAR inside the body to try to treat adults with relapsed or refractory B‑cell lymphoma.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07398963

• Dexamethasone before infliximab for moderate-to-severe Crohn's disease and ulcerative colitis

  This project will test whether giving an IV dose of dexamethasone before infliximab infusions prevents allergic reactions in people aged 14–80 with moderate-to-severe Crohn's disease or ulcerative colitis.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07385131

• Fexofenadine to improve recovery after a heart attack

  This trial will test whether taking the antihistamine fexofenadine after a recent STEMI heart attack helps reduce heart damage and improve recovery in adults.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07381803

• Leucogen to prevent ribociclib-related low white blood cell counts in early breast cancer

  This trial will test whether taking leucogen reduces the chance of severe neutropenia in women with early HR-positive/HER2-negative breast cancer who are starting ribociclib with endocrine therapy.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07380646

• Chemo plus anti-PD-1 therapy and sitagliptin before surgery for locally advanced pMMR colorectal cancer

  This trial tests whether adding sitagliptin and an anti‑PD‑1 antibody to standard pre‑surgery chemotherapy can increase tumor shrinkage in adults with locally advanced pMMR colorectal cancer.

  Recruiting Phase 1/2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07365592

• Leucine plus radiochemotherapy before surgery for locally advanced rectal cancer

  This will try whether taking oral leucine along with standard chemoradiotherapy before surgery helps people with locally advanced rectal cancer get a better tumor response.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07359989

• Dual-target CD19/BCMA CAR-T therapy for relapsed or refractory multiple myeloma

  This study will try a CAR-T treatment that targets both CD19 and BCMA to see if it helps people whose multiple myeloma has returned or not responded to prior therapies.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07359014

• iStent with cataract surgery to lower eye pressure in open-angle glaucoma

  This trial will see if placing an iStent during cataract surgery helps lower eye pressure in adults with open-angle glaucoma.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07354009

• Finding the best single IV dose of tegileridine for pain after orthopedic surgery

  This test tries single IV doses of tegileridine in adults 18–75 having orthopedic surgery to see which dose gives good pain relief after surgery.

  Recruiting Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hanzhong, Zhejiang · NCT07353996

• Pressurized intraperitoneal aerosol chemotherapy (PIPAC) with mitomycin or raltitrexed for colorectal cancer spread to the peritoneum

  This Phase I study tests PIPAC with mitomycin or raltitrexed alongside standard systemic chemotherapy to see if it is safe and to find the best dose for people whose colorectal cancer has spread to the peritoneum.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Other (Non U.s.) · NCT07349043

• Intensified HER2-targeted treatment for people with a suboptimal response to initial dual HER2 therapy and chemotherapy

  This trial will try stronger targeted drug combinations for people with HER2-positive early breast cancer who don't respond well to initial dual HER2-targeted therapy plus chemotherapy.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07340398

• Intrastromal anti-VEGF injection for corneal neovascularization

  We will test whether injecting anti-VEGF medicine into the cornea helps adults with corneal neovascularization caused by herpes simplex keratitis.

  Recruiting Phase 1/2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07329686

• 3D eye modeling to guide diagnosis and treatment of lens problems

  This project will try a full 3D eye model made from multiple scans to help surgeons plan treatment for people with complex lens problems such as dislocated, traumatic, or malformed lenses.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07321769

• Presbyopia-correcting intraocular lenses for complex cataracts with anterior segment abnormalities

  This trial will test whether presbyopia-correcting intraocular lenses provide better full-range vision and reduce the need for glasses compared with standard monofocal lenses in people having cataract surgery complicated by anterior segment abnormalities.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07321756

• Fecal transplant for chemotherapy and targeted-therapy gut side effects in advanced gastrointestinal cancer

  This trial will try oral fecal microbiota transplants (FMT) to see if they reduce chemotherapy or targeted-therapy–related gut symptoms in adults with advanced gastrointestinal cancers.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Zhejiang, Hangzhou · NCT07319364

• Laparoscopic vs Open Surgery for Colon Cancer in Patients with Visceral Obesity

  This study tests whether laparoscopic or open surgery leads to different long-term outcomes for adults with colon cancer and visceral obesity.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07314996

• mRNA vaccine targeting common glioma mutations for recurrent or progressive high-grade glioma

  This trial will test an mRNA vaccine that targets common glioma mutations to see if it is safe and helps the immune system fight recurrent or progressive high-grade glioma.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07306299

• ALA-PDT vs LEEP for cervical HSIL/CIN2: a multicenter non-randomized comparison

  This study tests whether a non-surgical photodynamic therapy (ALA-PDT) can match the effectiveness of LEEP for HSIL/CIN2 in women.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 4 other locations · NCT07306260

• ALA-PDT for cervical LSIL with HPV16/18 in multiple centers

  This study tests whether aminolevulinic acid–mediated photodynamic therapy can treat cervical LSIL in people with HPV16/18 compared with just observation.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 4 other locations · NCT07306247

• Epidural electrical stimulation to restore walking after spinal cord injury

  This study will try epidural electrical stimulation combined with rehabilitation to help people with chronic AIS C–D spinal cord injuries improve their walking ability.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07306052

• TuFEst-LN model test for axillary lymph node status in breast cancer

  This study tests whether the TuFEst-LN liquid biopsy model using cfDNA can help identify patients without axillary lymph node metastasis among those planned for upfront surgery, and see if combining TuFEst-LN results with preoperative MRI can predict post-neoadjuvant nodal status.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07304934

• Long-term follow-up for liver transplant recipients and living donors

  This project will follow people who receive liver transplants and those who donate part of a liver to see if clinical factors predict complications and long-term health.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07301853

• Do tiny coronary blood vessel problems affect outcomes in dilated cardiomyopathy?

  This project will test whether coronary microvascular dysfunction changes long-term outcomes for people with dilated cardiomyopathy.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07293338

• Semaglutide, Tirzepatide, or Metformin to slow biological age in adults with obesity.

  This 24-week test gives semaglutide, tirzepatide, or metformin to adults with obesity to see if the drugs slow or reverse accelerated biological (epigenetic) aging.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07293325

• Acupoint herbal patching to relieve qi deficiency and constipation during chemotherapy

  This trial tests whether applying herbal patches to acupuncture points can help adults with colorectal cancer who have qi deficiency and constipation while they receive postoperative chemotherapy.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07276932

• Control of anesthesia depth using continuous, non-invasive breath monitoring.

  This project tests whether continuous, non-invasive measurements of exhaled sevoflurane and propofol can predict BIS and guide anesthesia depth for adults having combined intravenous–inhalational surgery.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07272044

• Phycocyanin for liver protection in fibrosis and cirrhosis

  This trial will test whether a daily phycocyanin supplement can help adults with liver fibrosis or cirrhosis by lowering liver enzymes and improving liver stiffness.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07271576

• Tracking progression and consequences of heart valve disease

  This project will follow adults with moderate or worse valve disease to see if clinical tests and imaging can predict when their condition will get worse.

  Recruiting at 15 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Fuzhou, Fujian and 14 other locations · NCT07267117

• LILRA6 CAR-T therapy for relapsed or refractory acute myeloid leukemia.

  This trial will test LILRA6-directed CAR-T cell therapy to see if it helps adults (18–75) whose acute myeloid leukemia has returned or not responded to prior treatments.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07263906

• Spirulina to protect the liver and help recovery after partial hepatectomy

  This trial will test whether taking spirulina tablets before and after surgery helps people with cholangiocarcinoma protect their liver and recover faster after a partial hepatectomy.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07263217

• AI-powered ECG diagnosis and prognosis for hypertrophic cardiomyopathy

  This project will test whether artificial intelligence reading standard 12-lead ECGs can identify different types of hypertrophic cardiomyopathy and tell them apart from look‑alike heart conditions in adults.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07263204

• AK104 plus FOLFIRI with cetuximab or bevacizumab for second-line MSS advanced colorectal cancer

  This trial tests whether adding AK104 to FOLFIRI with either cetuximab or bevacizumab helps people with MSS advanced colorectal cancer who progressed after oxaliplatin-based first-line therapy.

  Recruiting at 2 sites Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 1 other locations · NCT07253896

• Portal pressure changes after banding or sclerotherapy for esophageal varices

  This will test whether endoscopic band ligation or sclerotherapy changes portal pressure measured by endoscopic ultrasound in adults with cirrhosis and esophagogastric varices.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07253090

• AI-powered multi-omics model to predict breast cancer distant and organ-specific metastasis

  This project will test whether combining tumor images, protein data, and gene sequencing with artificial intelligence can predict if and where breast cancer will spread for women who have stored metastatic tissue samples at the hospital.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07252986

• CEA-targeted CAR-T therapy for advanced CEA-positive solid tumors

  This trial will try a CEA-targeted CAR-T cell therapy in adults with advanced, CEA-positive non-small cell lung cancer or breast cancer who have progressed after standard treatments.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07250386

• CEA-targeted CAR-T therapy after cytoreductive surgery for peritoneal colorectal cancer

  This trial will test whether CEA-targeted CAR-T cells delivered into the abdomen after cytoreductive surgery can help people with colorectal cancer that has spread to the peritoneum.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07247396

• Ivonescimab plus chemotherapy before surgery for resectable esophageal squamous cell cancer

  This study tests whether giving Ivonescimab together with chemotherapy before esophageal cancer surgery helps patients see better outcomes than surgery alone.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07244978

• Non-invasive retinal imaging for early diagnosis of Parkinson's disease

  This project will test whether a quick, non-invasive eye (fundus) scan can spot early Parkinson's disease in people aged 40–80, including those with early PD, atypical parkinsonism, essential tremor, and healthy volunteers.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07244640

• UX-GIP001 cell therapy for adults with drug-resistant unilateral mesial temporal lobe epilepsy

  This treatment will try a one-time transplant of GABAergic interneuron progenitor cells into the affected side of the brain to see if it reduces seizures in adults with drug-resistant unilateral mesial temporal lobe epilepsy.

  Recruiting Early Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07244328

• Predicting breast cancer spread with AI-generated spatial pathology maps

  This study will try an AI model that uses routine pathology images and clinical data to predict long-term risk of distant metastasis in adult women who had surgery for primary invasive breast cancer.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Changchun, Jilin and 3 other locations · NCT07244094

• Envafolimab with doxorubicin and ifosfamide for advanced soft tissue sarcoma

  This trial will test whether adding envafolimab to doxorubicin and ifosfamide helps people with advanced soft tissue sarcoma respond better.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hanzhong, Zhejiang · NCT07243626

• Epidural electrical stimulation to restore function after T11–L3 spinal cord injury

  This study will see if epidural electrical stimulation can help people with chronic T11–L3 spinal cord injuries (ASIA B–D) regain motor and sensory function.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07207798

• AI-guided robotic minimally invasive neurosurgery for intracerebral hemorrhage (RAINBOW-ICH)

  This trial will test whether AI-assisted, robotic-guided minimally invasive surgery helps adults with spontaneous intracerebral hemorrhage (including basal ganglia, intraventricular, and brainstem types) recover better than conventional care.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07205263

• AI-assisted diagnosis for malignant brain tumors

  This project will test an AI system that uses routine preoperative MRI scans to automatically segment and classify malignant brain tumors in adults to help guide diagnosis and care.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 1 other locations · NCT07198256

• Stupp treatment plus intrathecal thiotepa for glioblastoma with ventricular or meningeal spread

  This trial will test whether adding intrathecal thiotepa to the Stupp regimen and radiotherapy helps adults with glioblastoma that has spread into the brain ventricles or meninges.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07193654

• Spatially fractionated radiotherapy combined with standard treatment for oligoprogressive non-small cell lung cancer.

  It tests whether adding spatially fractionated radiotherapy to standard systemic therapy helps people with oligoprogressive non-small cell lung cancer who have progressed after at least one prior systemic treatment.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07193641

• Bispecific B7H3/IL13Ra2 armored CAR-T therapy for recurrent or refractory glioblastoma

  This trial will try giving repeated intraventricular injections of EPC-003 bispecific CAR-T cells to adults with B7H3 and/or IL13Ra2 positive recurrent or refractory glioblastoma to see if it is safe and helps control the tumor.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07193628

• Searching for molecular markers linked to radiation-caused dry mouth in head and neck cancer patients

  This project will try to find blood, saliva, or tissue markers in adults with head and neck cancer getting radiotherapy to see if those markers can predict who will develop dry mouth.

  Recruiting at 3 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Nanjing, Jiangsu and 3 other locations · NCT07170358

• Umbilical cord blood CAR‑NK cells targeting TRBC1/2 for relapsed or refractory peripheral T‑cell lymphoma

  This will test whether umbilical cord blood‑derived CAR‑NK cells that target TRBC1/2 are safe and can help people with relapsed or refractory peripheral T‑cell lymphoma.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07164560

• Vebreltinib for advanced or metastatic clear cell sarcoma

  This study will try taking vebreltinib pills twice daily to treat people aged 12 and older with unresectable or metastatic clear cell sarcoma who have at least one measurable tumor.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07153887

• tDCS to improve swallowing in Parkinson's disease

  This study tests whether adding transcranial direct current stimulation (tDCS) to standard swallowing therapy helps people with Parkinson's disease who have dysphagia.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07153692

• Microneedle intra-arterial injection plus vitrectomy for acute retinal artery occlusion

  This trial will try a microneedle intra-arterial thrombolytic injection combined with vitrectomy to restore vision in adults with acute central retinal artery occlusion or macula-involving branch retinal artery occlusion within 7 days of symptoms.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07151755

• Accelerated intermittent theta burst stimulation for neuropathic pain

  This project will try accelerated intermittent theta burst stimulation (a rapid form of rTMS) versus standard 10‑Hz rTMS to reduce neuropathic pain in adults with peripheral neuropathy.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07148388

• With versus without internal limiting membrane peeling during surgery for idiopathic epiretinal membrane

  This trial will try removing the internal limiting membrane during vitrectomy to see if it improves vision or symptoms for adults with idiopathic epiretinal membrane who have reduced visual acuity or metamorphopsia.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07142785

• Precise diagnosis and treatment system for thyroid-associated eye disease

  This project will test whether a deep-learning system using eye images and exams can automatically diagnose, stage, and help plan treatment for people with thyroid-associated ophthalmopathy.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07124572

• Keverprazan plus amoxicillin versus rabeprazole-based therapy for first-line H. pylori treatment

  This test will see if Keverprazan plus amoxicillin for 10 or 14 days clears H. pylori in adults as well as or better than the standard rabeprazole quadruple therapy.

  Recruiting Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07122024

• Bailing Capsules with Guben Kechuan Granules for stable bronchiectasis

  This trial will try whether adding Bailing Capsules plus Guben Kechuan Granules to standard Western treatment reduces acute exacerbations in adults with stable bronchiectasis.

  Recruiting Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 4 other locations · NCT07114120

• Epidural electrical stimulation for restoring motor and sensory function after chronic spinal cord injury

  This will try epidural electrical stimulation to see if it helps people with chronic spinal cord injuries (ASIA B–D) regain motor and sensory function.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07105878

• Yangtze Delta hereditary ataxia multi-omics and clinical cohort

  This project will follow people with hereditary ataxia in the Yangtze River Delta and use multi-omics testing to see if genetic variants, molecular biomarkers, and disease mechanisms can be identified.

  Recruiting at 2 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 1 other locations · NCT07092358

• Orelabrutinib plus Pola‑R‑CHP for untreated non‑GCB diffuse large B‑cell lymphoma

  This trial tests whether adding orelabrutinib to the Pola‑R‑CHP chemotherapy improves responses in adults with newly diagnosed non‑GCB diffuse large B‑cell lymphoma.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07078500

• NALIRIFOX as second-line chemotherapy for advanced extrapulmonary high-grade neuroendocrine neoplasms

  This trial will try NALIRIFOX (liposomal irinotecan with fluorouracil and oxaliplatin) as a second-line treatment for adults with metastatic extrapulmonary high‑grade neuroendocrine neoplasms who progressed after first‑line therapy.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07077551

• VISOR for removing 1–3 cm kidney and ureter stones

  This will test a new device called VISOR to break up and remove 1–3 cm kidney or ureter stones in adults aged 18–80.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07071948

• First-line immunotherapy plus chemotherapy in extensive-stage small cell lung cancer

  This study tests whether adding Tafolecimab and Sintilimab to standard chemotherapy can help people with extensive-stage small cell lung cancer.

  Recruiting at 4 sites Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Changsha, Hunan and 4 other locations · NCT07061535

• First-line treatment with orelabrutinib plus rituximab for marginal zone lymphoma

  This will test whether taking orelabrutinib together with rituximab works and is safe as a first systemic treatment for adults with marginal zone lymphoma.

  Recruiting at 18 sites Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 17 other locations · NCT07022223

• Watching a short video before anti-VEGF eye injections

  This trial will test whether watching a brief procedural video before a first anti-VEGF intravitreal injection helps people with retinal diseases feel less anxious and have fewer or smaller subconjunctival hemorrhages.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07002372

• Comparing two treatments for advanced colorectal cancer

  This study is testing whether a combination of two cancer treatments works better than another combination for people with advanced colorectal cancer that hasn’t responded to other therapies.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06992648

• Combined CAR-DC and CAR-T Cell Therapy for Non-small Cell Lung Cancer

  This study is testing a new combination therapy using special immune cells to see if it can help people with advanced non-small cell lung cancer feel better and live longer.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06972576

• Sequential versus initial combination treatment for pulmonary arterial hypertension

  This trial tests whether starting with one drug and adding the second later works as well as starting both ambrisentan and tadalafil together for adults with PAH.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06968962

• Using combined iron supplements to reduce blood transfusions in heart surgery patients

  This study is testing if a mix of iron supplements and vitamin C can help heart surgery patients with low iron levels need fewer blood transfusions.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06968936

• Combining high-intensity focused ultrasound with immunotherapy and chemotherapy for breast cancer treatment

  This study is testing if combining high-intensity focused ultrasound with immunotherapy and chemotherapy can help women with a specific type of breast cancer more than just chemotherapy alone.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06964906

• Ciprofol's effect on low blood pressure during surgery in elderly patients on certain medications

  This study is testing if a new anesthetic called ciprofol can help prevent low blood pressure during surgery in older patients who have been taking certain heart medications.

  Recruiting Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06952608

• Treatment for advanced colorectal cancer using targeted CAR-T and CAR-DC therapies

  This study is testing a new combination treatment using special immune cells to see if it can help people with advanced colorectal cancer live longer and feel better.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06946615

• Online positive psychology program to improve mental health and quality of life in Crohn's disease

  This trial will try an online positive psychology program to improve mood and quality of life for adults with Crohn's disease who have mild to moderate anxiety or depression.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06939712

• Enhanced treatment for newly diagnosed glioblastoma after surgery

  This study is testing a new treatment plan for people with newly diagnosed glioblastoma after surgery to see if a combination of different drugs and higher radiation doses works better than the usual care.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT06936046

• Neoadjuvant radiotherapy for unresectable thymoma

  This study is testing if giving radiation therapy before surgery helps people with advanced thymoma have better outcomes compared to combining it with chemotherapy.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06924619

• Investigating joint issues in patients with Gitelman Syndrome

  This study is trying to see if people with Gitelman Syndrome also have joint problems caused by calcium deposits and how these issues can be managed.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06922370

• FAP-targeted immunosuppressive CAR-DC therapy for end-stage dilated cardiomyopathy

  Researchers are testing a new immune-cell therapy to see if it’s safe and helps people with end-stage dilated cardiomyopathy.

  Recruiting Phase 1/2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06902896

• Using betaine hydrochloride to treat autoimmune gastritis

  This study is testing whether betaine hydrochloride can help people with autoimmune gastritis feel better and reduce their health risks.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06881511

• Effect of Blood Management in Bone Tumor Surgery

  This study is testing if a blood management technique called acute normovolemic hemodilution can help people having bone tumor surgery avoid anemia and its complications.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06881498

• Combining SBRT and Lenalidomide for treating Solitary Plasmacytoma

  This study is testing whether combining a targeted radiation treatment with a medication can help people with a rare type of tumor called solitary plasmacytoma respond better to treatment and live longer without the disease progressing.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06863584

• Reducing brain swelling in patients with large ischemic stroke using a specialized medication

  This study is testing a new medication to see if it can help reduce brain swelling in people who have had a large ischemic stroke.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06863571

• Using PCSK9 inhibitors to lower cholesterol in patients with high-risk coronary plaques

  This study tests if adding a new cholesterol-lowering medication to standard treatment can help people with high-risk heart plaques avoid serious heart and brain problems.

  Recruiting at 5 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 5 other locations · NCT06863545

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

Quick answers

How many clinical trials run by Second Affiliated Hospital, Zhejiang University, School of Medicine are recruiting right now?

284, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in China (284 trials), South Korea (1 trial), United States (1 trial), Singapore (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 56, Phase 1: 18, Phase 4: 16, Phase 3: 12. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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