Accelerated intermittent theta burst stimulation for neuropathic pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized interventional study compares an accelerated intermittent theta burst stimulation (AiTBS) schedule to conventional 10‑Hz repetitive TMS applied to the left primary motor cortex for adults with peripheral neuropathic pain. Participants are randomly assigned to either an AiTBS arm (up to six sessions per day across five days within ten days) or ten consecutive days of standard 10‑Hz rTMS. Clinical pain measures and neurophysiological recordings of corticospinal excitability using TMS‑EEG are collected at baseline and after the final treatment session. The trial was designed as the first repeated‑session therapeutic test of AiTBS in this patient population to compare analgesic magnitude and cortical excitability changes against standard rTMS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* IASP diagnosis of peripheral neuropathic pain;
* At least three months after the onset of pain;
* At least moderate pain intensity (≥ 3 assessed by VAS or NRS);
* 18 years or older;
* Stable medical treatment from 2 weeks before allocation to the end of the trial;
* Willing to receive TMS treatment and capable of fulfilling clinical assessments.

Exclusion Criteria:

* Contradictions to TMS treatment, such as metal implants or seizure;
* Serious psychiatric disorder (Hamilton Depression Rating Scale score ≥ 35 or Hamilton Anxiety Rating Scale score ≥ 29);
* Aphasia or cognitive disorders (Mini mental state examination ≤ 24);
* Severe clinical disorders caused by tumor or other conditions;
* Severe cardiopulmonary dysfunction or extreme weakness;
* History of substance abuse (alcohol, drugs).

Where it's running

• The Second Affiliated Hospital of Zhejiang University School of Medicine
  Hangzhou, China Recruiting

Study contacts

• Study coordinator: Ying Liu
• Email: 350373328@qq.com
• Phone: 86-15595512306

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.