Ciprofol's effect on low blood pressure during surgery in elderly patients on certain medications

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the impact of ciprofol, a new intravenous anesthetic, on preventing low blood pressure during surgery in elderly patients who have been taking renin-angiotensin system inhibitors for over three months. The research focuses on patients undergoing elective abdominal surgery lasting more than two hours, assessing whether ciprofol can provide better hemodynamic stability compared to the traditional anesthetic propofol. Given the increased risk of intraoperative hypotension in this demographic, the findings could significantly influence anesthetic practices for these vulnerable patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients undergoing elective abdominal surgery under general anesthesia
2. Duration of surgery exceeding 2 hours
3. Patients receiving long-term renin-angiotensin system inhibitor therapy (\>3 months prior to surgery)
4. Age ≥ 65 years
5. ASA classification II-III
6. Informed consent was obtained from patients or their guardians

Exclusion Criteria:

1. History of allergy to opioids, propofol, or ciprofol components.
2. Anticipated difficult airway (limited mouth opening, restricted neck movement, or modified Mallampati grade III-IV) or difficult mask ventilation.

   Body mass index ≤18 or ≥35 kg/m².
3. Severe hepatic dysfunction (total bilirubin ≥3.0 mg/dL or AST/ALT ≥2 times the upper limit of normal).
4. Severe renal impairment (creatinine clearance ≤30 mL/min).
5. Cardiac diseases (AV block higher than first-degree, heart rate \<50 bpm, severe arrhythmias, severe valvular heart disease, heart failure, or unstable angina on the day of surgery).
6. Preoperative cognitive impairment, cerebrovascular disease, or history of psychiatric illness.
7. Abnormal thyroid-stimulating hormone levels or history of thyroid replacement therapy.
8. Unstable asthma or history of asthma.
9. Alcohol abuse, drug abuse, chronic opioid dependence, or analgesic use exceeding 3 months.
10. Lactating or pregnant women.

Where it's running

• The Second Affiliated Hospital of Zhejiang University anesthesiology department
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Min Yan
• Email: zryanmin@zju.edu.cn
• Phone: 0571-87783759

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.