Effect of Blood Management in Bone Tumor Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the impact of acute normovolemic hemodilution (ANH) on postoperative hemoglobin levels in patients undergoing elective bone tumor resection surgery. It aims to determine if ANH, when combined with goal-directed fluid therapy (GDFT), can reduce the risk of perioperative anemia and its associated complications. The trial is designed as a randomized, controlled trial to provide robust data on the efficacy of this blood management strategy in a high-risk surgical setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. age 18 to 75 years;
2. undergoing elective bone tumor resection surgery;
3. preoperative hemoglobin ≥11 g/dL;

Exclusion Criteria:

1. using a tourniquet;
2. palliative operation or minimally invasive surgery;
3. BMI\<18.5 or \>30Kg/m\^2;
4. international normalized ratio (INR) \>1.5 or platelet count \<100 × 10\^9/L;
5. cardiopulmonary insufficiency;
6. hepatic and renal dysfunction;
7. active infectious disease;
8. allergy to succinyl gelatin;
9. pregnancy;
10. declined participation in the study or declined blood transfusion

Where it's running

• The Second Affiliated Hospital of Zhejiang University anesthesiology department
  Hangzhou, Zhejiang, China Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  Recruiting Nanjing Chia-tai Tianqing Pharmaceutical · Changsha, Hunan · NCT06977750

• Analysis of outcomes after surgery for bone tumors in the proximal femur

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  Recruiting Istituto Ortopedico Rizzoli · Bologna, BO · NCT06486506

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.