Brain activation during mirror-hand movements after stroke (fNIRS)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Right-handed adults 18–75 who had a first ischemic or hemorrhagic stroke within six months, have very weak affected finger muscles (≤ grade 1), and meet cognitive and tone criteria are enrolled in the hospital rehabilitation ward. Researchers record cortical signals with functional near-infrared spectroscopy (fNIRS) while participants perform or observe mirror-image movements of the healthy hand, with informed consent and standard screening (e.g., MMSE). This is an observational protocol with no interventional treatment; data will compare hemispheric activation patterns during mirror movement conditions. Exclusion criteria include prior brain injury, epilepsy, significant peripheral nerve injury, or inability to follow instructions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* It meets the diagnostic criteria of the "Guidelines for the Prevention and Treatment of Cerebrovascular Diseases in China", and is diagnosed as cerebral infarction or cerebral hemorrhage by CT or MRI.
* The first stroke occurred;
* The muscle strength of the flexor and extensor muscles of the affected finger is ≤ grade 1.
* Right-handed player
* Muscle tone improvement: Asworth level 2 or below;
* The disease course is within 6 months and the condition is stable.
* Age: 18 to 75 years old, with normal vision and hearing or corrected to normal.

Exclusion Criteria:

* Those with an MMSE score less than 20, severe memory, communication and speech command comprehension disorders, and those who cannot cooperate with examinations and treatments;
* Those with a history of epilepsy;
* Those with a history of stroke, traumatic brain injury or brain tumor in the past;
* Those with peripheral nervous system injuries other than stroke as diagnosed by imaging;
* Those with visual spatial impairments such as visual field defects and unilateral neglect;
* Skull defect or metal bone plates
* For those who are not suitable for functional near-infrared examination;
* Those with a history of intracranial surgery.
* Patients with lesion areas in the cerebellum or brainstem.

Where it's running

• The Second Affiliated Hospital of Zhejiang University School of Medicine
  Hangzhou, China Recruiting

Study contacts

• Study coordinator: Jiasheng Zhu, Bachelor's
• Email: zhujiasheng321@sina.com
• Phone: +86 15157177433

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.