Precise diagnosis and treatment system for thyroid-associated eye disease
Official title: Construction and Application of Precise Diagnosis and Treatment System for Thyroid-associated Ophthalmopathy
Run by Second Affiliated Hospital, Zhejiang University, School of Medicine · NCT07124572 · Data updated 2026-11-12
This project will test whether a deep-learning system using eye images and exams can automatically diagnose, stage, and help plan treatment for people with thyroid-associated ophthalmopathy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 7 Years to 90 Years |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Second Affiliated Hospital, Zhejiang University, School of Medicine Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Status | Recruiting |
| Started | October 1, 2022 |
| Main results expected | October 1, 2030 |
| Study ends | October 1, 2031 |
| Registry record updated | August 15, 2025 |
| Trial ID | NCT07124572 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are cooperative adults with thyroid-associated ophthalmopathy who can undergo imaging and ocular examinations, alongside control participants without eyelid disorders for comparison.
✕Probably not a fit
People with pupil or corneal disorders or a history of eye injury are excluded and are unlikely to benefit from this program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study will develop a deep learning model that integrates multimodal data from imaging and ocular examinations to provide automated diagnosis, staging, grading, treatment suggestions, and prognosis predictions for thyroid-associated ophthalmopathy (TAO). Researchers will collect standardized eye images and clinical exam data from both patients with TAO and control participants without eyelid disorders to train and validate the system. Observational methods will be used to compare model outputs to clinical labels and current diagnostic standards, with cases meeting exclusion criteria (pupil/cornea disorders, prior eye injury) omitted. The goal is to create a tool that supports clinicians by synthesizing image and exam data into consistent, actionable reports.
Why it matters
Potential benefit: If successful, the system could speed and standardize diagnosis and treatment decisions for TAO, potentially leading to earlier and more consistent care.
How similar studies have gone: Deep learning has shown promise in several ophthalmic diagnoses, but applying multimodal AI specifically to thyroid-associated ophthalmopathy is relatively new.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * normal participants without eyelid disorders (control group) * patients with thyroid-associated ophthalmopathy (TAO group) * cooperative participants Exclusion Criteria: * participants with pupil or cornea disorders * participants with history of eye injury
Where it's running
-
Juan Ye
Hangzhou, Zhejiang, China Recruiting
Study contacts
- Study coordinator: Juan Ye
- Email: yejuan@zju.edu.cn
- Phone: +86-571-87783897
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.