Clinical trial Recruiting at 1 site Observational Ages 7 to 90

Precise diagnosis and treatment system for thyroid-associated eye disease

Official title: Construction and Application of Precise Diagnosis and Treatment System for Thyroid-associated Ophthalmopathy

Run by Second Affiliated Hospital, Zhejiang University, School of Medicine · NCT07124572 · Data updated 2026-11-12

This project will test whether a deep-learning system using eye images and exams can automatically diagnose, stage, and help plan treatment for people with thyroid-associated ophthalmopathy.

Quick facts

Study typeObservational
Ages7 Years to 90 Years
SexAll
Enrollment500 (estimated)
SponsorSecond Affiliated Hospital, Zhejiang University, School of Medicine
Academic / other
Locations1 site (Hangzhou, Zhejiang)
StatusRecruiting
StartedOctober 1, 2022
Main results expectedOctober 1, 2030
Study endsOctober 1, 2031
Registry record updatedAugust 15, 2025
Trial IDNCT07124572 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are cooperative adults with thyroid-associated ophthalmopathy who can undergo imaging and ocular examinations, alongside control participants without eyelid disorders for comparison.

Probably not a fit

People with pupil or corneal disorders or a history of eye injury are excluded and are unlikely to benefit from this program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study will develop a deep learning model that integrates multimodal data from imaging and ocular examinations to provide automated diagnosis, staging, grading, treatment suggestions, and prognosis predictions for thyroid-associated ophthalmopathy (TAO). Researchers will collect standardized eye images and clinical exam data from both patients with TAO and control participants without eyelid disorders to train and validate the system. Observational methods will be used to compare model outputs to clinical labels and current diagnostic standards, with cases meeting exclusion criteria (pupil/cornea disorders, prior eye injury) omitted. The goal is to create a tool that supports clinicians by synthesizing image and exam data into consistent, actionable reports.

Why it matters

Potential benefit: If successful, the system could speed and standardize diagnosis and treatment decisions for TAO, potentially leading to earlier and more consistent care.

How similar studies have gone: Deep learning has shown promise in several ophthalmic diagnoses, but applying multimodal AI specifically to thyroid-associated ophthalmopathy is relatively new.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* normal participants without eyelid disorders (control group)
* patients with thyroid-associated ophthalmopathy (TAO group)
* cooperative participants

Exclusion Criteria:

* participants with pupil or cornea disorders
* participants with history of eye injury

Where it's running

  • Juan Ye
    Hangzhou, Zhejiang, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.