CT-FFR in Chronic Coronary Syndrome: A multicenter look at risk and outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, multicenter, observational study conducted in China to see if abnormal CT-FFR results from CCTA scans are linked to higher risk of major adverse clinical events over 1 year in patients with chronic coronary syndrome. Researchers will analyze real-world data from patients who have already undergone CCTA and CT-FFR testing, focusing on functional significance beyond anatomy. The study does not assign treatments but aims to clarify how CT-FFR findings could influence risk stratification and management decisions. Enrollment includes adults with CCS who had valid CT-FFR results, excluding those with ACS or poor image quality, and who consent to follow-up. Outcomes will help determine the prognostic value of CT-FFR in routine clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years.
* Clinical diagnosis of chronic coronary syndrome (CCS).
* Completed coronary computed tomography angiography (CCTA) examination and successfully obtained CT-derived fractional flow reserve (CT-FFR) results.
* The subject or their legal representative voluntarily participates in this study and has signed the written informed consent form.

Exclusion Criteria:

* Acute coronary syndrome (ACS), including ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), or acute episodes of unstable angina.
* Unable to obtain valid CT-FFR results, or the image quality is insufficient to support analysis.
* Pregnant patients or those who intend to become pregnant during the study period.
* Non-cardiac comorbidities indicating a life expectancy of less than one year.
* Failure to sign the informed consent form.
* Inability to complete the follow-up or explicit refusal to participate in the follow-up.
* Patients with cognitive impairment or psychiatric disorders confirmed by clinical diagnosis or investigator assessment.
* Patients who are illiterate or semi-literate, or who, due to any visual impairment or reading/writing disability, are unable to independently read the subject information sheet without assistance and are unable to personally provide written informed consent.
* Any other conditions deemed unsuitable for participation in this study by the investigators

Where it's running

• Second Affiliated Hospital, School of Medicine, Zhejiang University
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Principal investigator: Jun Jiang, MD — Second Affiliated Hospital, Zhejiang University, School of Medicine
• Study coordinator: Jun Jiang, MD
• Email: jiang-jun@zju.edu.cn
• Phone: +(86) 13588706891

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.