tDCS to improve swallowing in Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized interventional study will assign people with Parkinson's-related dysphagia to real tDCS plus conventional dysphagia treatment or sham tDCS plus conventional treatment. Swallowing function will be measured at baseline, after the intervention, and at a 3-month follow-up using videofluoroscopic swallowing study (VFSS) and clinical swallowing scales. Brain function will be tracked with resting-state fMRI or functional near-infrared spectroscopy (fNIRS), using ALFF and functional connectivity analyses to map changes in networks and regions. The study will correlate imaging changes with swallowing recovery to explore the neurophysiological mechanism of tDCS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Meet the Chinese Diagnostic Criteria for Parkinson's Disease (2016) or MDS Diagnostic Criteria for Multiple System Atrophy or Progressive Supranuclear Palsy;
* VFSS examination indicates dysphagia;
* Mini-Mental State Examination (MMSE) score \>23;
* Willing to cooperate with the study and sign the informed consent form;

Exclusion Criteria:

* Comorbid with other diseases that cause dysphagia;
* Comorbid with pneumonia, or severe cardiac/renal insufficiency;
* Having metal implants in the body
* With cognitive impairment or inability to cooperate.

Where it's running

• Second Affiliated Hospital of Zhejiang University School of Medicine
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Principal investigator: Ping Wang — Second Affiliated Hospital of Zhejiang University School of Medicine
• Study coordinator: Ping Wang, MS
• Email: wangping6288@zju.edu.cn
• Phone: 15158113194

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How surgery for obstructive sleep apnea affects swallowing and oral function

  This study compares swallowing and oral function before and after surgical treatment for OSA versus non-surgical care in adults with moderate-to-severe OSA.

  Recruiting National Sun Yat-sen University · Kaohsiung City · NCT07880067

• taVNS added to oral motor training for babies with severe swallowing trouble

  This trial tests whether pairing a noninvasive taVNS treatment with oral sensorimotor training helps infants in NICUs swallow better and feed more safely.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07802301

• Digital Tongue-Pressure Biofeedback Training for Post-Stroke Swallowing

  This study tests whether digital tongue-pressure biofeedback training helps people with swallowing difficulties after stroke.

  Recruiting Phase 2 First People's Hospital of Foshan · Foshan, Guangdong · NCT07798401

• Masseter and Thigh Muscle Ultrasound to Predict Dysphagia and Sarcopenia in Critically Ill Adults

  This study tests whether measuring the masseter muscle with ultrasound can help identify dysphagia in adults after critical illness and extubation, alongside evaluation of sarcopenia.

  Recruiting Hospital General Universitario Gregorio Marañon · Madrid, Madrid · NCT07787312

• Impact of Patient Position on EndoFLIP Measurements in Kids and Young Adults

  This study tests whether EndoFLIP measurements differ when patients are in the supine versus left-side position during the procedure.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07780981

• MAO-B PET/CT imaging in Parkinson’s-related diseases

  This study tests whether 18F-FPyCO/SMBT-1 PET/CT can help diagnose Parkinson’s-related conditions by measuring lesion uptake in patients with PD, PD dementia, or parkinsonism.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT07685873

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.