Effects of linear accelerator X-rays on red blood cells collected during cancer surgery
Official title: A Multi-dimensional Evaluation of the Effects of Linear Accelerator X-ray Irradiation on the Morphology, Mechanical Properties and Functions of Red Blood Cells
Run by Second Affiliated Hospital, Zhejiang University, School of Medicine · NCT07416045 · Data updated 2026-11-12
This project will test whether X-rays from a linear accelerator change the structure and function of red blood cells collected from adults undergoing cancer surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Second Affiliated Hospital, Zhejiang University, School of Medicine Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Status | Recruiting |
| Started | January 28, 2026 |
| Main results expected | February 26, 2027 |
| Study ends | February 26, 2027 |
| Registry record updated | February 17, 2026 |
| Trial ID | NCT07416045 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 scheduled for elective malignant tumor surgery with an expected blood loss of ≥500 mL are ideal candidates.
✕Probably not a fit
Patients with preexisting red blood cell production disorders or hemolytic conditions (for example, aplastic anemia, thalassemia, PNH, or G6PD deficiency) are unlikely to benefit and are excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will collect red blood cells recovered during elective oncologic surgeries and expose them to different doses of X-rays delivered by a clinical linear accelerator. They will use atomic force microscopy, microfluidic chips, biochemical assays, microtubule suction techniques, and cross-scale numerical simulation to measure membrane ultrastructure, deformability, flow behavior, and oxygen-carrying capacity. The study will map dose–effect relationships between irradiation dose and measures of red blood cell damage. Findings aim to provide preclinical evidence to guide safe irradiation processing of autologous blood for intraoperative salvage.
Why it matters
Potential benefit: If successful, this could identify safe X-ray doses for treating salvaged autologous blood and lower the risk of transfusing damaged red blood cells during cancer surgery.
How similar studies have gone: While irradiation is used elsewhere for blood product safety, applying linear accelerator X-rays specifically to intraoperative autologous red blood cells is relatively novel and lacks extensive prior clinical data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients scheduled for elective surgery for malignant tumors * Age: 18 - 65 years old * It is estimated that the surgical bleeding will be greater than or equal to 500 milliliters. Exclusion Criteria: * Disorders of red blood cell production (such as aplastic anemia, megaloblastic anemia, iron deficiency anemia, leukemia, myelofibrosis, etc.) * Diseases caused by increased destruction of red blood cells (abnormalities in red blood cell membranes such as hereditary spherocytosis and paroxysmal nocturnal hemoglobinuria; abnormalities in hemoglobin such as thalassemia; abnormalities in red blood cell-related enzymes such as glucose-6-phosphate dehydrogenase deficiency, etc.)
Where it's running
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The Second Affiliated Hospital, School of Medicine, Zhejiang University,anesthesiology department,
Hangzhou, Zhejiang, China Recruiting
Study contacts
- Study coordinator: Fengjiang Zhang
- Email: zrzfj@zju.edu.cn
- Phone: +8613858007629
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.