Using betaine hydrochloride to treat autoimmune gastritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the efficacy of betaine hydrochloride in patients diagnosed with autoimmune gastritis, a condition characterized by the destruction of gastric parietal cells leading to various complications such as anemia and increased cancer risk. Participants will receive either betaine hydrochloride or no intervention, and their health outcomes will be monitored to assess the treatment's effectiveness. The study aims to provide a potential disease-modifying therapy for a condition that currently lacks effective treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients diagnosed with autoimmune gastritis at the Second Affiliated Hospital of Zhejiang University School of Medicine, with the diagnostic criteria for autoimmune gastritis based on the article "A real-world study on the characteristics of autoimmune gastritis: A single-center retrospective cohort in China" published by our team in the journal Clinics and Research in Hepatology and Gastroenterology;
2. Gastrin levels greater than 300 pmol/L or a history of type 1 gastric neuroendocrine tumors or early gastric cancer treated with endoscopic submucosal dissection (ESD);
3. Age between 18 and 80 years;
4. Patients who have signed the informed consent form for the clinical trial.

Exclusion Criteria:

1. Patients allergic to betaine hydrochloride;
2. Patients with peptic ulcers;
3. Patients with any condition other than autoimmune gastritis that causes elevated gastrin levels (e.g., gastrinoma);
4. Patients who refuse to sign the informed consent form.

Where it's running

• The Second Affiliated Hospital, Zhejiang University School of Medicine
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Jianshan Mao, MD, PhD
• Email: jshmao@zju.edu.cn
• Phone: +86-571-8778-3540

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating small intestinal bacterial overgrowth in autoimmune gastritis patients using breath tests

  This study is testing if people with autoimmune gastritis have more small intestinal bacterial overgrowth by using breath tests and comparing their results to others on acid suppression therapy and a control group.

  Recruiting RenJi Hospital · Shanghai, Shanghai Municipality · NCT06946706

• Methods for treating high gastrin levels in autoimmune gastritis patients

  This study is testing different treatments for people with autoimmune gastritis to see if they can help lower high gastrin levels and improve related symptoms.

  Recruiting The First Affiliated Hospital of Zhengzhou University · Zhengzhou, Henan · NCT06272500

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.