Multimodal Cardiac MRI to See How the Heart Is Working

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, prospective observational registry enrolling about 2,000 adults with suspected or confirmed cardiovascular disease. Participants undergo a comprehensive multi-modal CMR that includes Cine imaging, T1/T2 mapping, late gadolinium enhancement, and 4D flow to evaluate anatomy, function, tissue characteristics, and hemodynamics. The study also explores sequence optimization and AI-based techniques, aiming to standardize protocols and build a large imaging database for better diagnosis and prognosis. Findings may inform how multi-modal CMR can improve clinical decision-making across ischemic and non-ischemic heart diseases. The project emphasizes non-contrast and AI-driven imaging options to potentially reduce risk and improve efficiency.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 years and older, with no gender restrictions.

Clinically suspected or confirmed cardiovascular disease (including but not limited to ischemic heart disease, non-ischemic cardiomyopathy, myocarditis, valvular disease, etc.), requiring a cardiac magnetic resonance (CMR) examination to determine the etiology or evaluate myocardial tissue characteristics.

No contraindications to magnetic resonance examination, and able to cooperate with breath-holding instructions.

Voluntarily participate in this study and sign a written informed consent form.

Exclusion Criteria:

* Absolute contraindications: Implantation of non-MRI compatible metallic foreign bodies (e.g., old pacemakers, implantable cardioverter-defibrillators \[ICD\], aneurysm clips, etc.).

Relative contraindications: Severe claustrophobia, unable to complete the examination despite communication.

Severe renal insufficiency.

Special populations: Pregnant or lactating women.

Presence of severe arrhythmias (e.g., persistent atrial fibrillation) leading to severely impaired magnetic resonance signal acquisition, rendering the image quality inadequate for diagnosis.

Poor expected compliance: Unable to complete follow-up, or deemed unsuitable for enrollment by the investigator for other reasons.

Where it's running

• The Second Affiliated Hospital Zhejiang University School of Medicine
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: jiaqi Fan
• Email: jqfan@zju.edu.cn
• Phone: +86 15267029492

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.