Condition
Soft Tissue Sarcoma clinical trials and research
As of November 12, 2026, Find a Trial lists 59 Soft Tissue Sarcoma clinical trials that are recruiting, at sites in 25 countries (most in United States (24), China (11), France (8)). 3 were first registered in the last 30 days. By phase: Phase 2 (19), Phase 1 (6), Phase 3 (5), Phase 1/2 (4). The most active sponsors are Second Affiliated Hospital, Zhejiang University, School of Medicine (3), University Health Network, Toronto (3), Institut Claudius Regaud (3). There are also 14 NIH-funded research projects on Soft Tissue Sarcoma, with $10.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 59Clinical trials
- 14NIH research projects
- 3New in 30 days
- 25Countries
Newest Soft Tissue Sarcoma clinical trials
All recruiting trials (59)
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68Ga-HX01 PET/CT Imaging in Soft Tissue Sarcoma patients
This study tests whether a 68Ga-HX01 injection can help PET/CT imaging better characterize soft tissue sarcoma in adults who have exhausted standard treatments or have no good options.
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Zemetostat plus Anlotinib for SWI/SNF-deficient Head and Neck Soft Tissue Sarcoma
This trial tests whether zemetostat plus anlotinib can help people with recurrent or metastatic head-and-neck soft tissue sarcoma that has SWI/SNF complex deficiency after standard therapy fails.
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Entinostat for pediatric soft tissue sarcoma with PAX abnormalities
This study tests entinostat, alone or with chemotherapy, in children whose soft tissue sarcomas have PAX-family gene abnormalities to see if it can help shrink tumors or slow progression.
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Methionine-Reduced Diet in Solid Tumors (early-phase)
A small pilot study will test whether a methionine-reduced diet can change blood levels in adults with various solid tumors who are receiving standard cancer therapy.
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Preoperative Immunonutrition for bone and soft tissue sarcoma patients
This study tests whether a short course of an oral nutrition supplement before surgery can help patients with bone or soft tissue sarcomas recover better after major tumor-related surgery.
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Adaptive Proton Therapy for Pediatric Solid Tumors and Hodgkin Lymphoma
This study tests a regular imaging approach to see if proton therapy plans for children with solid tumors or Hodgkin lymphoma should be updated during treatment.
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Contrast-enhanced ultrasound to monitor soft tissue sarcoma during neoadjuvant radiation
This pilot will try contrast-enhanced ultrasound with Definity in adults with localized soft tissue sarcoma who are receiving pre-surgery radiation to see if it can guide radiation planning and predict treatment response.
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Zanzalintinib plus pembrolizumab for select advanced soft-tissue sarcomas
This trial will test whether combining zanzalintinib with pembrolizumab can help control certain advanced or metastatic soft-tissue sarcomas in adults.
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Targeted radioligand [177Lu]Lu-DFC413 for advanced pancreatic, lung, breast, and colorectal cancers
This will test a new targeted radioactive medicine, [177Lu]Lu-DFC413 (with a PET tracer [68Ga]Ga-NNS309), to see if it is safe and shows activity in adults with advanced pancreatic, lung, breast, or colorectal cancer.
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Envafolimab with doxorubicin and ifosfamide for advanced soft tissue sarcoma
This trial will test whether adding envafolimab to doxorubicin and ifosfamide helps people with advanced soft tissue sarcoma respond better.
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Single-protein encapsulated doxorubicin (SPEDOX-6) for advanced solid tumors
We will try SPEDOX-6, a protein-encapsulated form of doxorubicin, to find a safe dose and see if it helps adults with advanced, treatment-resistant solid tumors (including certain sarcomas, triple-negative breast cancer, non-small cell lung cancer, cervical, ovarian, and KRAS‑mutant pancreatic cancers) who have not rec
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Neoadjuvant atezolizumab and doxorubicin with preoperative radiation and adjuvant atezolizumab for high‑risk resectable limb and trunk soft tissue sarcoma
This will test whether adding the immunotherapy atezolizumab to doxorubicin chemotherapy before surgery, with radiation before surgery and more atezolizumab after surgery, can delay relapse in adults with high‑risk, resectable soft tissue sarcoma of the arms, legs, or trunk.
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Capmatinib treatment for adults with cancers having MET gene changes
This study is testing if capmatinib, a drug for lung cancer, can help adults with different types of cancers that have changes in the MET gene.
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Recovery and quality of life after limb-sparing surgery for soft tissue sarcoma
This project will see how body image, quality of life, walking ability, and joint and muscle function are in people who had limb-sparing surgery for localized soft tissue sarcoma of an arm or leg.
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Evaluating MT-4561 in Patients with Advanced Solid Tumors
This study is testing a new drug called MT-4561 to see if it is safe and effective for people with advanced solid tumors.
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Preoperative radiotherapy for soft tissue sarcoma
This study tests if a shorter course of radiation therapy before surgery can help people with soft tissue sarcoma in their arms, legs, or trunk while protecting healthy tissue and reducing side effects.
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Using preoperative radiotherapy and surgery for treating soft tissue sarcoma in limbs
This study is testing if giving radiation therapy before surgery can help people with large or difficult-to-remove soft tissue tumors in their arms or legs feel better and have better outcomes.
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Imaging soft tissue sarcoma using a radioactive version of olaratumab
This study is testing a new radioactive version of a drug called olaratumab to see if it can help doctors better spot soft tissue sarcoma tumors in patients.
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Treatment for children with relapsed soft tissue sarcoma using a new drug combination
This study is testing a new combination of drugs to see if it works better than another treatment for children aged 2 to 21 with relapsed soft tissue sarcoma.
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Combining Anlotinib with Doxorubicin and Radiotherapy for Soft Tissue Sarcoma Treatment
This study is testing if combining a cancer drug called anlotinib with chemotherapy and radiation can help people with high-grade soft tissue sarcoma have better treatment results before surgery.
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Using 68Ga-DOTATATE PET/CT to diagnose soft tissue sarcomas
This study is testing a new type of imaging called 68Ga-DOTATATE PET/CT to see if it can help doctors better diagnose soft tissue sarcomas in patients.
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Exploring genetic factors in retroperitoneal liposarcoma recurrences
This study is trying to see if changes in the fat around a type of cancer called retroperitoneal liposarcoma can help explain why it comes back after treatment.
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Using a special dye to guide surgery for sarcoma removal
This study is testing whether a special dye can help surgeons remove sarcomas more accurately by showing them where the cancer ends during surgery.
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Dostarlimab treatment for advanced or metastatic cancers with specific genetic markers
This study is testing if the immunotherapy dostarlimab can help people with certain advanced cancers that have specific genetic markers feel better compared to standard chemotherapy.
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Using tislelizumab to treat cancer patients with detectable tumor DNA after surgery
This study is testing if the immunotherapy drug tislelizumab can help cancer patients who have had surgery and still have traces of tumor DNA in their blood to avoid a relapse.
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Assessing early psychiatric referral effects on mental health in sarcoma patients
This study tests whether getting early mental health support helps sarcoma patients feel less anxious and depressed while recovering from surgery.
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5-day preoperative radiation for soft tissue sarcoma
This study tests whether a shorter, five-day radiation treatment before surgery can safely help people with soft tissue sarcoma in their arms, legs, or abdomen just as well as the usual longer treatment.
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Evaluating radiation therapy for older patients with soft tissue sarcoma
This study is testing a type of radiation therapy to see if it helps older patients with soft tissue sarcoma heal better after surgery.
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Using MRI to predict metastasis in soft tissue sarcoma patients
This study is testing if a special type of MRI can help doctors see if soft tissue sarcoma patients have low oxygen levels in their tumors, which could help them choose better treatments right from the start.
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Comparing negative pressure dressing to standard dressing for healing after soft tissue sarcoma surgery
This study is testing if a special type of dressing called negative pressure therapy can help people heal better after surgery for soft tissue sarcoma compared to regular dressings.
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Combining Cadonilimab and Anlotinib for Advanced Soft Tissue Sarcoma
This study is testing a new combination treatment of cadonilimab and anlotinib to see if it helps people with advanced soft tissue sarcoma who haven't had success with other treatments.
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Pre-operative proton therapy for soft tissue sarcoma
This study tests if a special type of radiation therapy given before surgery can help people with soft tissue sarcomas in their arms or legs heal better and have a better quality of life afterward.
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Preoperative radiation therapy for soft tissue sarcoma
This study is testing a new type of radiation treatment before surgery to see if it can help people with soft tissue sarcoma have better outcomes.
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Investigating Tigilanol Tiglate for Soft Tissue Sarcoma Treatment
This study is testing if a new treatment called tigilanol tiglate can help shrink tumors and control disease in people with advanced soft tissue sarcoma in their arms or legs.
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Combining pembrolizumab with pazopanib for treating metastatic soft tissue sarcoma
This study is testing if combining two drugs, pembrolizumab and pazopanib, can help people with metastatic soft tissue sarcoma feel better compared to using pazopanib alone.
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Combination treatment for advanced soft tissue sarcoma
This study is testing if adding a new treatment called tTF-NGR to standard chemotherapy can help people with advanced soft tissue sarcoma live longer without their cancer getting worse.
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Biobank for patients with aggressive tumors
This study is collecting blood and tumor samples from patients with aggressive cancers to see if they can find clues to create better, personalized treatments.
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Personalized exercise program to improve recovery for soft tissue sarcoma patients
This study is testing whether a personalized exercise program can help patients with soft tissue sarcoma recover better during their treatment compared to those who only receive educational materials.
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Using GnRHa to protect fertility during chemotherapy for young women
This study is testing if a hormone treatment can help young women keep their ability to have children while they undergo chemotherapy for cancer.
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Pre-surgery ultra-hypofractionated radiation for retroperitoneal soft tissue sarcoma
This study tests a very short course of pre-surgery high-dose radiation followed by surgery to see if it is safe and manageable for people with retroperitoneal soft tissue sarcoma.
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Non-invasive treatment for soft tissue sarcoma using focused ultrasound
This study is testing a new non-invasive ultrasound treatment for people with soft tissue sarcomas to see if it can safely shrink their tumors.
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Evaluating quality of life and functional outcomes in sarcoma patients after limb salvage surgery
This study looks at how limb salvage surgery affects the quality of life and daily functioning of people aged 18 to 95 who have had surgery for bone or soft tissue sarcoma in their legs.
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Combining Atezolizumab and Tivozanib for Treating Certain Cancer Types
This study is testing a new combination of two cancer drugs, Atezolizumab and Tivozanib, to see if they can help people with tough-to-treat cancers like bile duct, gallbladder, breast, and neuroendocrine tumors.
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Using HER2 CAR T cells with checkpoint inhibitors for advanced sarcoma
This study is testing a new treatment that combines personalized CAR T cells with immune boosters to see if it helps people with advanced HER2-positive sarcoma.
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Exercise program for patients with soft tissue sarcoma
This study tests if an exercise program before surgery can help patients with soft tissue sarcoma recover better and heal faster after treatment.
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B7-H3 CAR T-cell therapy for pediatric solid tumors
This study is testing a new type of immune therapy using specially modified T cells to see if it can help children with tough-to-treat solid tumors.
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Sequential chemotherapy for soft tissue sarcoma
This study tests if giving two types of chemotherapy before surgery can help people with high-grade soft tissue sarcoma live longer and be cancer-free.
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Combining toripalimab with CAV/IE chemotherapy for advanced soft tissue sarcoma
This study is testing if adding toripalimab to standard chemotherapy can help people with advanced soft tissue sarcoma who haven't had success with other treatments.
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Combining Retifanlimab with chemotherapy for advanced soft tissue sarcoma
This study is testing if adding Retifanlimab to chemotherapy can help people with advanced soft tissue sarcoma fight their cancer better than the usual treatments.
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Evaluating Trabectedin for Advanced Leiomyosarcoma
This study is testing if a drug called Trabectedin can help people with advanced leiomyosarcoma feel better and live longer compared to another treatment called Gemcitabine.
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Adding chemotherapy to surgery for high-risk localized soft tissue sarcoma
This study is testing if adding chemotherapy to surgery can help people with high-risk localized soft tissue sarcoma live longer without their cancer spreading.
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Quality assessment of sarcoma care in Europe and Latin America
This study looks at how well patients with different types of sarcoma are treated in Europe and Latin America to see if care is better at expert centers and to find ways to improve outcomes.
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Vaccination with Dendritic Cells for Patients with Resected Stage IV Rare Cancers
This study is testing a new vaccine made from patients' own immune cells to see if it can help people who have had rare stage IV cancers feel better and stay healthy after surgery.
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Using Abemaciclib to treat certain bone and soft tissue sarcomas with specific genetic alterations
This study is testing if the drug Abemaciclib can help people with certain types of bone and soft tissue sarcomas that have specific genetic changes.
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Characterizing rare soft tissue sarcomas
This study is trying to learn more about rare types of soft tissue sarcomas by collecting detailed information from 400 patients to help improve treatment options.
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Analyzing blood samples for tumor DNA in soft tissue sarcoma patients
This study is testing if blood samples from soft tissue sarcoma patients can help find tumor DNA to see if it can predict how likely the cancer is to come back after treatment.
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Comparing vacuum dressings to standard dressings after surgery for soft tissue sarcoma
This study is testing if using vacuum dressings instead of standard dressings after surgery can help patients with soft tissue sarcoma heal better and improve their quality of life.
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Phase 3 test of anlotinib (AL3818) versus dacarbazine in advanced alveolar soft part sarcoma, leiomyosarcoma, and synovial sarcoma
This trial tests whether anlotinib (AL3818) helps adults with advanced alveolar soft part sarcoma, while earlier arms compared anlotinib to dacarbazine for leiomyosarcoma and synovial sarcoma that are no longer enrolling.
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New method to deliver chemotherapy directly into the lungs for sarcoma patients
This study is testing a new way to deliver chemotherapy directly into the lungs during surgery for sarcoma patients to see if it can better target hidden cancer cells and improve their outcomes.
NIH-funded research (14)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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SPORE in Soft Tissue Sarcoma: targeted therapies and biomarkers to help patients
A big research effort at a major cancer center aims to develop targeted treatments and biomarkers to improve outcomes for people with soft tissue sarcoma.
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Ultra-steerable ultrasound therapy for soft tissue sarcoma
A new ultrasound device is being developed to non-invasively shrink or remove soft tissue sarcomas while protecting nearby nerves, blood vessels, and bones.
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Robotic ultrasound system to non-invasively remove soft tissue sarcoma
A robotic ultrasound approach aims to precisely destroy soft tissue sarcoma tumors without open surgery for people with large or hard-to-reach tumors.
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Boosting NK-cell therapy for soft tissue sarcoma using a dog model
This project combines an antibody that soaks up a tumor-made immune blocker with natural killer (NK) cell therapy to help dogs and, eventually, people with soft tissue sarcoma fight their tumors.
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Targeted treatments for soft tissue sarcoma
This project is testing targeted drugs and immunotherapies for people with soft tissue sarcoma, including adults and children.
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Enhancing cancer treatment using natural killer cells in dogs with soft tissue sarcoma
This study is looking at a new way to help treat soft tissue sarcoma in dogs by using special immune cells called natural killer cells, along with a targeted antibody, to make the treatment more effective and hopefully improve outcomes for our furry friends.
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Non-invasive treatment for soft tissue sarcoma using ultrasound technology
This study is testing a new ultrasound treatment that gently breaks down tough tumors in soft tissues, making it easier for patients with hard-to-reach sarcomas to manage their cancer without needing surgery.
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Using ultrasound to non-invasively destroy soft tissue sarcomas
This study is testing a new, gentle way to treat soft tissue sarcomas using focused ultrasound, which aims to destroy the tumors without harming nearby important structures, and it's designed to help improve the treatment experience and quality of life for patients like you.
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New treatments for soft tissue sarcoma and cancers linked to Agent Orange exposure
This study is working on new medicines to help people with soft tissue sarcoma and other cancers linked to Agent Orange, focusing on how certain cancer cells grow and resist treatment, with the hope of finding better ways to improve patient care.
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Investigating the roles of specific genes in the development and spread of soft tissue sarcomas.
This study is looking at how specific genes might play a role in the growth and spread of soft tissue sarcomas, which are rare and tough tumors, to help find better treatment options for patients like you.
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Understanding how soft tissue sarcomas respond to radiation therapy
This study is looking at tumor and blood samples from patients with soft tissue sarcomas to find out why some tumors don’t respond well to radiation therapy, with the goal of making radiation treatment more effective for those patients.
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Using immune cells from soft tissue sarcoma to create personalized cancer treatments
This study is testing a new cancer treatment that uses your own immune cells to help fight metastatic soft tissue sarcoma, and it's designed for patients like you who want a personalized approach to their care.
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Investigating how glutamine metabolism affects immune cell development in soft-tissue sarcomas
This study is looking at how a nutrient called glutamine affects certain immune cells in soft-tissue sarcoma, with the goal of finding new ways to boost the immune response and improve treatment options for patients.
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Developing targeted therapies for soft tissue sarcoma
This study is looking for better ways to treat soft tissue sarcoma by focusing on the unique genetic changes in this cancer, and it will involve both adults and children to find out what works best.
Related topics
Quick answers
How many Soft Tissue Sarcoma clinical trials are recruiting right now?
59, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 25 countries. The most sites are in United States (24 trials), China (11 trials), France (8 trials), Italy (5 trials), Canada (5 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 19, Phase 1: 6, Phase 3: 5, Phase 1/2: 4. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.