Combining Anlotinib with Doxorubicin and Radiotherapy for Soft Tissue Sarcoma Treatment

A Prospective, Open-Label, Single-Arm Clinical Study of Anlotinib Combined With Doxorubicin Monotherapy and Radiotherapy as Neoadjuvant Treatment for Soft Tissue Sarcoma

This study is testing if combining a cancer drug called anlotinib with chemotherapy and radiation can help people with high-grade soft tissue sarcoma have better treatment results before surgery.

Quick facts

• Phase: PHASE4
• Study type: Interventional
• Enrollment: 39 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Guangdong Provincial People's Hospital (other)
• Drugs / interventions: sunitinib, imatinib, famitinib, chemotherapy, immunotherapy, Anlotinib, Doxorubicin, radiation
• Locations: 2 sites (Guangzhou, Guangdong and 1 other locations)
• Trial ID: NCT06506838 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the efficacy and safety of anlotinib combined with doxorubicin and radiotherapy as a neoadjuvant treatment for patients with high-grade soft tissue sarcoma. The study involves administering doxorubicin in a standard regimen alongside anlotinib, followed by radiotherapy before surgical resection. Participants will receive a total of six cycles of chemotherapy, with radiotherapy starting after the second cycle. The trial aims to determine if this combination improves treatment outcomes for patients with this type of cancer.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18-75 with high-grade soft tissue sarcoma that is suitable for surgical resection.

Not a fit: Patients with low-grade soft tissue sarcoma or those not suitable for surgery may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment approach could enhance the effectiveness of neoadjuvant therapy for patients with soft tissue sarcoma, potentially leading to better surgical outcomes.

How similar studies have performed: Other studies have explored similar combinations of chemotherapy and radiotherapy, showing promising results, but this specific combination is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Age 18-75 years.
2. ECOG Performance Status score of 0-1.
3. Histologically or cytologically confirmed diagnosis of high-grade soft tissue sarcoma (G2-G3), classified as moderately sensitive or higher to chemotherapy (or determined suitable for radiotherapy and chemotherapy by the investigator). Typically includes histological types such as synovial sarcoma, vascular sarcoma, adult fibrosarcoma, intramuscular chondrosarcoma, leiomyosarcoma, liposarcoma, undifferentiated pleomorphic sarcoma, hepatic undifferentiated embryonic sarcoma, and unclassified soft tissue sarcomas.
4. Clinical confirmation of soft tissue sarcoma suitable for surgical resection after multidisciplinary assessment.
5. Presence of at least one measurable lesion according to RECIST v1.1 assessment criteria and suitable for ≥40 Gy/f radiotherapy (or determined suitable for radiotherapy by the investigator).
6. Laboratory and other examinations:Hematology: Absolute neutrophil count ≥1500/μL, platelet count ≥100,000/μL. Pulmonary function: No respiratory difficulty at rest, no reduced exercise tolerance, resting pulse oximetry \>94% in room air.

   Renal function (creatinine clearance or radioisotope GFR ≥70 mL/min/1.73 m² or serum creatinine within normal limits according to age/gender). Liver function (total bilirubin ≤1.5 × ULN, AST or ALT \<2.5 × ULN). Cardiac function: Left ventricular ejection fraction (LVEF) ≥50%.
7. Signed informed consent and good compliance.
8. Reproductive-age women must use reliable contraception or have a negative pregnancy test (serum or urine) within 7 days before enrollment and agree to use appropriate contraception during the study and for 8 weeks after the last dose of investigational drug.

Exclusion Criteria:

1. Active autoimmune disease or history of autoimmune disease.
2. Receipt of any form of anti-tumor treatment within 4 weeks prior to enrollment, including radiotherapy, chemotherapy, molecular targeted therapy (such as angiogenesis inhibitors like sunitinib, sorafenib, imatinib, famitinib, regorafenib), and immunotherapy (eligible if last anti-tumor drug was stopped ≥5 half-lives before enrollment), or participation in another interventional clinical trial.
3. History of or current simultaneous malignancy within 3 years, excluding cured lung cancer, cervical carcinoma in situ, non-melanoma skin cancer, and superficial bladder tumors \[Ta (non-invasive tumors), Tis (carcinoma in situ), and T1 (tumor invades lamina propria)\].
4. Unresectable sarcomas, including severe vascular, neural, or bone involvement, or cases where complete surgical resection is not safely feasible.
5. Factors affecting oral medication (such as dysphagia, severe chronic diarrhea, and intestinal obstruction, etc.).
6. History of bleeding, with any grade 3 or higher bleeding event as per CTCAE 4.0 within 4 weeks before screening.
7. Uncontrolled diseases or past medical history, such as:

   * NYHA Class ≥2 heart failure, unstable angina, myocardial infarction within the past 12 months.
   * Active infections requiring systemic treatment.
   * Known HIV infection, syphilis history, psychiatric disorders (such as epilepsy and dementia), or substance abuse disorders.
   * Thromboembolic events (including transient ischemic attacks, cerebral hemorrhage, cerebral infarction), deep vein thrombosis, and pulmonary embolism within the past 6 months before enrollment.
8. According to NYHA standards, Class III-IV heart failure, or left ventricular ejection fraction (LVEF) \<50% on echocardiography.
9. Major surgery within 4 weeks prior to randomization or severe traumatic injury, fracture, or ulcer.
10. Long-standing unhealed wounds or fractures.
11. Pregnancy or lactation in women.
12. Known allergy to any investigational drug.
13. Investigator judgment that the subject has other factors that may lead to premature termination of the study, such as severe laboratory abnormalities, family or social factors affecting subject safety, or data and sample collection.

Where this trial is running

Guangzhou, Guangdong and 1 other locations

• Guangdong Provincial People's Hospital — Guangzhou, Guangdong, China (RECRUITING)
• Guangdong provincial people's hospital — Guangzhou, Guangdong, China (RECRUITING)

Study contacts

• Study coordinator: Yu Zhang, Ph.D.

Conditions: Soft Tissue Sarcoma, Doxorubicin, Radiotherapy, doxorubicin