New treatments for soft tissue sarcoma and cancers linked to Agent Orange exposure
First-in-class small molecules for treatment of soft tissue sarcoma and other cancers associated with Agent Orange exposure
['FUNDING_OTHER'] · JAMES J PETERS VA MEDICAL CENTER · NIH-10951498
This study is working on new medicines to help people with soft tissue sarcoma and other cancers linked to Agent Orange, focusing on how certain cancer cells grow and resist treatment, with the hope of finding better ways to improve patient care.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JAMES J PETERS VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-10951498 on ClinicalTrials.gov |
What this research studies
This research focuses on developing first-in-class small molecules to treat soft tissue sarcoma and other cancers associated with Agent Orange exposure. It aims to target specific pathways in cancer cells that contribute to their growth and resistance to existing therapies. By investigating the roles of Hypoxia Inducible Factors (HIF) and Acyl-CoA synthetase in tumor development, the research seeks to create effective treatments that can improve patient outcomes. The approach involves both laboratory studies and potential clinical applications to address the challenges faced by patients with advanced cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with soft tissue sarcoma or other cancers linked to Agent Orange exposure.
Not a fit: Patients with cancers not associated with Agent Orange exposure or those with early-stage cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from cancers related to Agent Orange exposure, potentially improving survival rates.
How similar studies have performed: While targeting Acss2 and HIF-2 is a novel approach, similar strategies have shown promise in other cancer types, indicating potential for success.
Where this research is happening
BRONX, UNITED STATES
- JAMES J PETERS VA MEDICAL CENTER — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARCIA, JOSEPH ANTHONY — JAMES J PETERS VA MEDICAL CENTER
- Study coordinator: GARCIA, JOSEPH ANTHONY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.