Condition

Ewing Sarcoma clinical trials and research

• 40Clinical trials
• 43NIH research projects
• 25Countries

Newest Ewing Sarcoma clinical trials

All recruiting trials (40)

• Dynamic ProGRP Changes During Ewing Sarcoma Treatment

  This study tests whether changes in serum ProGRP levels over time reflect how well newly diagnosed Ewing sarcoma responds to treatment.

  Recruiting Peking University People's Hospital · Beijing · NCT07725783

• Methionine-Reduced Diet in Solid Tumors (early-phase)

  A small pilot study will test whether a methionine-reduced diet can change blood levels in adults with various solid tumors who are receiving standard cancer therapy.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT07628634

• Adaptive Proton Therapy for Pediatric Solid Tumors and Hodgkin Lymphoma

  This study tests a regular imaging approach to see if proton therapy plans for children with solid tumors or Hodgkin lymphoma should be updated during treatment.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07514819

• Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

  This trial tests whether adding eflornithine (DFMO) as extra or maintenance therapy can improve survival for young people with Ewing sarcoma or osteosarcoma.

  Recruiting at 3 sites Phase 2 Milton S. Hershey Medical Center · Tampa, Florida and 2 other locations · NCT07321912

• Xaluritamig for relapsed or refractory Ewing sarcoma in adults, adolescents, and children

  This trial will test xaluritamig in adults, adolescents, and children with relapsed or refractory Ewing sarcoma to find a recommended dose for expansion and check safety and tolerability.

  Recruiting at 13 sites Phase 1 Amgen · Los Angeles, California and 12 other locations · NCT07297979

• Hypofractionated radiation plus B7-H3 CAR T cells for children and young adults with relapsed sarcoma

  This will test whether short-course radiation given before B7-H3 CAR T-cell therapy is safe for children and young adults (≤21) with relapsed or refractory B7-H3–positive sarcomas.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07222735

• ST-01156, a drug that degrades RBM39, for advanced solid cancers

  This trial will test whether ST-01156 is safe and shows early anti-cancer activity in adults (and some teens with Ewing sarcoma) who have advanced or metastatic solid tumors like liver, biliary tract, or Ewing sarcoma.

  Recruiting at 6 sites Phase 1 SEED Therapeutics, Inc. · Duarte, California and 5 other locations · NCT07197554

• Biologically-adapted, dose-escalated radiotherapy for Ewing sarcoma

  This trial tests whether giving higher radiotherapy doses tailored to tumor size and biology helps people aged 2 and older with Ewing sarcoma control their tumors better.

  Recruiting at 2 sites Mayo Clinic · Phoenix, Arizona and 1 other locations · NCT07188532

• Personalized B7-H3 CAR T cells combined with PRAME antigen-specific T cells for relapsed embryonal tumors

  This trial tests a combined personalized B7-H3 CAR T cell and PRAME-specific T cell infusion after lymphodepleting chemotherapy in children and young adults with relapsed or refractory embryonal tumors.

  Recruiting Phase 1 Children's National Research Institute · Washington D.C., District of Columbia and 1 other locations · NCT07172958

• Detecting cancer cells in frozen ovarian or testicular tissue from children with neuroblastoma or Ewing sarcoma

  This project will test whether RT-qPCR or droplet digital PCR (ddPCR) better detects leftover neuroblastoma or Ewing sarcoma cells in frozen ovarian or testicular tissue from children treated during infancy.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand, Auvergne · NCT07141862

• DXC008 treatment for prostate cancer and other solid tumors

  This phase 1 trial will test whether DXC008 is safe and shows early anti-cancer activity in adults with prostate cancer or other advanced solid tumors who have exhausted standard therapies.

  Recruiting at 4 sites Phase 1 Hangzhou DAC Biotechnology Co., Ltd. · Changsha, Hunan and 3 other locations · NCT06926283

• Irinotecan liposome plus temozolomide and fluzoparib for recurrent or metastatic Ewing sarcoma

  This will test a combination of liposomal irinotecan, temozolomide, and the PARP inhibitor fluzoparib in adults with recurrent or metastatic Ewing sarcoma after first-line chemotherapy.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT06827717

• Targeted radiation therapy for young patients with metastatic sarcoma

  This study is testing if a special type of radiation therapy can help young patients with metastatic sarcoma live longer and have fewer health issues compared to those who don’t receive it.

  Recruiting at 3 sites Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia and 2 other locations · NCT06796543

• Preventing chemotherapy-related side effects in Ewing's sarcoma patients using Trilaciclib

  This study is testing if adding Trilaciclib to standard chemotherapy can help prevent low blood cell counts in patients with Ewing's sarcoma who haven't had treatment before.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT06699472

• Alpha/beta T‑Cell and B‑Cell Depletion plus Zoledronic Acid for Pediatric and Young Adult Solid Tumors

  This study will try removing alpha/beta T cells and B cells from donor stem cell grafts and giving zoledronic acid to see if it helps children and young adults (6 months to 25 years) with relapsed or high‑risk solid tumors tolerate allogeneic transplant and reduce relapse.

  Recruiting Phase 1/2 University of Florida · Gainesville, Florida · NCT06625190

• Zanzalintinib treatment for advanced leiomyosarcoma

  This study is testing if a new medication called zanzalintinib can help people with advanced leiomyosarcoma live longer without their cancer getting worse.

  Recruiting Phase 2 Northwestern University · Chicago, Illinois · NCT06571734

• Evaluating KC1036 for treating advanced Ewing sarcoma in adolescents

  This study is testing a new treatment called KC1036 to see if it can help teenagers with advanced Ewing sarcoma who have run out of other treatment options.

  Recruiting Phase 2 Beijing Konruns Pharmaceutical Co., Ltd. · Beijing, Beijing Municipality · NCT06564272

• Using silmitasertib with chemotherapy for relapsed solid tumors

  This study is testing a new drug called silmitasertib combined with chemotherapy to see if it helps people with relapsed solid tumors feel better and manage their cancer.

  Recruiting at 24 sites Phase 1/2 Milton S. Hershey Medical Center · Birmingham, Alabama and 23 other locations · NCT06541262

• Eflornithine (DFMO) plus AMXT 1501 for neuroblastoma, CNS tumors, and sarcomas

  This trial tests whether adding the oral drug AMXT 1501 to oral DFMO can help children and young adults (diagnosed by age 21) with relapsed or refractory neuroblastoma, ETMR, ATRT, Ewing sarcoma, osteosarcoma, or newly diagnosed DIPG.

  Recruiting at 14 sites Phase 1/2 Milton S. Hershey Medical Center · Birmingham, Alabama and 13 other locations · NCT06465199

• Zilovertamab Vedotin for Pediatric and Young Adult Cancer Patients

  This study is testing a new drug called zilovertamab vedotin to see if it can help kids and young adults with certain types of cancer that haven't responded to other treatments.

  Recruiting at 70 sites Phase 1/2 Merck Sharp & Dohme LLC · Los Angeles, California and 70 other locations · NCT06395103

• Weekly irinotecan liposomes for Ewing Sarcoma

  This study tests if a new way of giving irinotecan, using liposomes, can help people with tough cases of Ewing Sarcoma feel better and improve their treatment results.

  Recruiting Phase 1 Peking University People's Hospital · Jina, Shandong and 2 other locations · NCT06340204

• Identifying factors that affect survival in Ewing Sarcoma patients

  This study looks at how different factors like age and tumor size affect survival rates in people with Ewing sarcoma to help doctors create better treatment plans for patients at higher risk.

  Recruiting Istituto Ortopedico Rizzoli · Bologna, BO · NCT06243588

• Using cabozantinib with ifosfamide to treat Ewing's sarcoma and osteosarcoma

  This study is testing if a new combination of cabozantinib and high-dose ifosfamide can help children and young adults with Ewing's sarcoma and osteosarcoma that hasn't responded to previous treatments.

  Recruiting at 4 sites Phase 1 Children's Hospital of Philadelphia · San Francisco, California and 3 other locations · NCT06156410

• Personalized cancer vaccine for patients with fusion-driven sarcomas

  This study is testing a personalized cancer vaccine for patients with certain types of sarcomas to see if it can help their immune system fight the cancer and improve their chances of living longer.

  Recruiting Phase 1/2 University Hospital Tuebingen · Essen and 3 other locations · NCT06094101

• Comparing single vs double beam proton therapy for certain tumors

  This study is testing whether using one beam of proton therapy is just as effective and safer than using two beams for patients with certain types of tumors.

  Recruiting Centre Antoine Lacassagne · Nice · NCT06029218

• Evaluating Naxitamab for Refractory Ewing's Sarcoma

  This study is testing if adding Naxitamab to chemotherapy can help people with hard-to-treat Ewing's Sarcoma feel better compared to standard treatment alone.

  Recruiting Phase 2 Institute of Mother and Child, Warsaw, Poland · Warsaw, Mazowian and 1 other locations · NCT05968768

• Using lurbinectedin to treat specific tumors in children and young adults

  This study is testing if a new drug called lurbinectedin can help children and young adults with certain types of tumors, like Ewing sarcoma, by targeting the proteins that make the tumors grow.

  Recruiting at 6 sites Phase 1/2 Children's Hospital of Philadelphia · Los Angeles, California and 5 other locations · NCT05918640

• Personalized home exercise program for patients with bone tumors after surgery

  This study tests whether a personalized home exercise program helps patients with bone tumors recover better after surgery and chemotherapy.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT05779670

• Lurbinectedin treatment for young patients with relapsed Ewing sarcoma

  This study is testing if a new drug called lurbinectedin can safely help young patients with relapsed Ewing sarcoma feel better and improve their treatment options.

  Recruiting at 16 sites Phase 1/2 Jazz Pharmaceuticals · Los Angeles, California and 15 other locations · NCT05734066

• Using GnRHa to protect fertility during chemotherapy for young women

  This study is testing if a hormone treatment can help young women keep their ability to have children while they undergo chemotherapy for cancer.

  Recruiting at 4 sites Phase 3 Karolinska University Hospital · Gothenburg and 16 other locations · NCT05328258

• Combining pembrolizumab and cabozantinib for advanced sarcomas

  This study is testing if combining two treatments, pembrolizumab and cabozantinib, can help people with advanced types of sarcoma feel better and improve their condition.

  Recruiting at 6 sites Phase 2 Institut Bergonié · Bordeaux and 9 other locations · NCT05182164

• Investigating early ageing in young cancer patients during treatment

  This study is trying to see how cancer treatment affects early aging and heart health in young adults aged 18-39 who are undergoing therapy for cancer.

  Recruiting University Medical Center Groningen · Groningen · NCT05062707

• Using HER2 CAR T cells with checkpoint inhibitors for advanced sarcoma

  This study is testing a new treatment that combines personalized CAR T cells with immune boosters to see if it helps people with advanced HER2-positive sarcoma.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT04995003

• B7-H3 CAR T-cell therapy for pediatric solid tumors

  This study is testing a new type of immune therapy using specially modified T cells to see if it can help children with tough-to-treat solid tumors.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04897321

• Using Metformin to Prevent Relapse in Bone Sarcoma Patients

  This study is testing if Metformin can help prevent relapse in patients with osteosarcoma and Ewing sarcoma who are at high risk of their cancer coming back.

  Recruiting Phase 2 Istituto Ortopedico Rizzoli · Bologna · NCT04758000

• Combining vorinostat with chemotherapy for relapsed solid tumors and CNS cancers

  This study is testing if adding a drug called vorinostat to chemotherapy can help people with relapsed solid tumors and brain cancers feel better and improve their treatment outcomes.

  Recruiting Phase 1 New York Medical College · Valhalla, New York · NCT04308330

• Using Regorafenib to Maintain Treatment Benefits After Initial Therapy for Bone Sarcomas

  This study is testing if the drug regorafenib can help people with bone sarcomas stay cancer-free longer after their initial treatment.

  Recruiting at 12 sites Centre Leon Berard · Besançon and 15 other locations · NCT04055220

• Testing INBRX-109 for advanced solid tumors including sarcomas

  This study is testing a new treatment called INBRX-109 for people with advanced solid tumors, like Ewing sarcoma and colorectal cancer, to see how safe it is and if it works better with standard chemotherapy.

  Recruiting at 32 sites Phase 1 Inhibrx Biosciences, Inc · Scottsdale, Arizona and 36 other locations · NCT03715933

• Transplantation with modified stem cells and Zoledronate for pediatric cancers

  This study is testing a new way to use modified stem cells and a drug called Zoledronate to see if it can safely help children with tough-to-treat cancers.

  Recruiting Phase 1 University of Wisconsin, Madison · Madison, Wisconsin · NCT02508038

• Combination therapy with MM-398 liposome irinotecan and cyclophosphamide in children with solid tumors

  This study tests whether a higher dose of MM-398 (liposomal irinotecan) can be given safely when used with cyclophosphamide in children with recurring or treatment-refractory solid tumors.

  Recruiting at 5 sites Phase 1 South Plains Oncology Consortium · Cincinnati, Ohio and 4 other locations · NCT02013336

NIH-funded research (newest 40 of 43)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• AI-powered prognostic model for Ewing sarcoma using digital pathology

  Researchers are building an AI tool to predict survival for children and adults with Ewing sarcoma using digitized pathology slides.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11440620

• RAPID: A patient-centered, fast-tracked drug trial platform for young people with relapsed Ewing sarcoma and DSRCT

  A patient-friendly, open-label phase 2 platform trial tests promising drug combinations for teens and young adults whose Ewing sarcoma or DSRCT has come back or not responded to treatment.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11440318

• TGFβ brakes immune evasion and metastasis in Ewing sarcoma during radiation

  A physician-scientist will study whether blocking TGFβ during radiation can help CAR T cells fight Ewing sarcoma and improve patient outcomes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11435865

• Function and Targeting of ETV6 in Ewing Sarcoma

  A scientist at Case Western Reserve University is studying a specific protein, ETV6, that helps a rare bone cancer called Ewing sarcoma, with the goal of finding targeted therapies that could spare healthy cells.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11408636

• Targeting immune markers in Ewing Sarcoma to guide safer, more effective therapies

  A funded project at Stanford aims to use immune markers on Ewing Sarcoma to develop targeted immunotherapies that work in children and adults with this cancer.

  NIH research Stanford University · Stanford, United States · NIH-11396515

• Ewing sarcoma: how DNA repair weaknesses affect risk and treatment

  A clinician-researcher team at Dana-Farber is studying how DNA damage repair weaknesses help drive Ewing sarcoma in kids and teens, with the goal of better predicting risk and guiding therapy.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11383129

• Novel OTUD7A inhibitors to treat Ewing sarcoma

  A scientist team is developing new small-molecule drugs that block OTUD7A to slow or stop Ewing sarcoma in children and young adults.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11381166

• Radiation-boosted treatment ideas for high-risk Ewing sarcoma with STAG2 loss

  A Mayo Clinic team is studying how combining radiation with new treatments may better help kids and teens with aggressive Ewing sarcoma that has lost STAG2.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11366203

• Targeting PAK4 in Ewing sarcoma to improve outcomes

  A new approach aims to block PAK4, a protein that helps Ewing sarcoma spread, to improve survival for patients with this pediatric bone cancer.

  NIH research Emory University · Atlanta, United States · NIH-11365885

• Understanding how USP1 helps Ewing sarcoma cells bypass replication stress

  Researchers are studying how a protein called USP1 lets Ewing sarcoma cells survive stress that would normally stop cancer growth.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11362462

• How transcription and RNA processing drive Ewing sarcoma

  Researchers are looking at how a fusion gene causes abnormal RNA transcription and splicing in Ewing sarcoma in children and young adults.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11330324

• Targeting the protein SIRT5 with new drugs for Ewing sarcoma

  New drugs that block or break down a protein called SIRT5 are being developed to treat children and young adults with Ewing sarcoma.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11330232

• Mechanisms of Toxicity from Excess EWS/FLI1 in Ewing Sarcoma

  A pediatric bone cancer study looking at what happens when too much EWS/FLI1 protein is present in Ewing sarcoma cells and how this could reveal new ways to treat the disease.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11322022

• How ancestry affects Ewing sarcoma genes using patient-derived stem cells

  Researchers are using stem cells from people of different ancestries to see how the EWS‑FLI1 cancer driver acts in Ewing sarcoma and why risk differs among children.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11309092

• Targeting a DNA repair weakness in Ewing sarcoma

  This project aims to exploit a DNA repair weakness to develop new treatments for children and young adults with Ewing sarcoma.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11240282

• Abnormal protein assemblies that change gene activity in Ewing sarcoma

  This project looks at whether abnormal protein clumps made by the EWS‑FLI1 fusion change gene activity in Ewing sarcoma tumors to find new treatment targets for adolescents and young adults with this bone cancer.

  NIH research University of Arizona · Tucson, United States · NIH-11239764

• Targeting proteoglycan signaling in Ewing sarcoma in kids and teens

  Aims to understand and slow down a deadly bone/soft-tissue cancer in young patients by studying a zebrafish model and how certain cell signals drive tumor growth.

  NIH research Children's Research Institute · Washington, United States · NIH-11231979

• Targeting ETV6 in Ewing sarcoma

  This project aims to create treatments that block the ETV6 protein to help children and young adults with Ewing sarcoma.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11191597

• Immune treatment targeting gangliosides in Ewing sarcoma

  This project is developing CAR T-cell immunotherapy that targets ganglioside molecules to help children and young adults with Ewing sarcoma.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11169949

• Targeting immune markers on Ewing sarcoma tumors

  This project aims to develop immune-based therapies that target proteins commonly found on Ewing sarcoma tumors in children and young adults.

  NIH research Stanford University · Stanford, United States · NIH-11159641

• Understanding and targeting a protein called PAK4 in Ewing sarcoma

  This research explores a specific protein in Ewing sarcoma to find new ways to treat patients with this bone cancer.

  NIH research Emory University · Atlanta, United States · NIH-11145239

• Understanding how Ewing Sarcoma cells avoid natural defenses

  This research explores how Ewing sarcoma cancer cells manage to keep growing even when they should stop or die, focusing on a protein called USP1.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11139515

• Targeting a protein to treat Ewing sarcoma in children

  This study is looking at a protein called IGF2BP1 to see how it affects the growth of Ewing sarcoma, a type of bone cancer in kids, with the goal of finding better treatments for this tough disease.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11116836

• Investigating the role of ETV6 in Ewing sarcoma treatment

  This study is looking at how a specific protein called ETV6 helps Ewing sarcoma cells survive, with the hope of finding new treatments for kids and young adults battling this tough bone cancer.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11111471

• Understanding how too much EWS/FLI1 protein affects Ewing sarcoma cells

  This study is looking at how high levels of a specific protein affect Ewing sarcoma, a type of bone cancer that mostly affects kids, to find out how we can help make cancer cells die off and discover new ways to treat this disease.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11085216

• Targeting a specific enzyme to treat Ewing Sarcoma in children and adolescents

  This study is looking at how a special enzyme helps Ewing Sarcoma cells survive, with the hope of finding new treatments for kids and teens with this type of cancer by using innovative techniques to block that enzyme.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11075134

• Understanding how ancestry affects Ewing sarcoma through stem cell models

  This study is looking at how genetics and ancestry might affect Ewing sarcoma, a type of cancer, by using special cells from people of different backgrounds to see how a specific protein influences the disease, which could help us find better treatments for patients.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11054605

• Investigating how DNA damage affects immune responses in Ewing sarcoma

  This study is looking at how damage to DNA in Ewing sarcoma cells can trigger the immune system, with the hope of finding new ways to treat this childhood cancer, especially for kids whose cancer comes back.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11045047

• Investigating a unique DNA repair issue in Ewing sarcoma

  This study is looking at how Ewing sarcoma, a bone cancer that mainly affects teens and young adults, can be treated better by understanding why some DNA repair processes don't work properly in the cancer cells, and it hopes to find new ways to improve treatment for patients.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11024979

• New treatments for Ewing sarcoma using SIRT5 inhibitors

  This study is exploring new ways to treat Ewing sarcoma, a tough cancer that mostly affects kids and young adults, by looking at how blocking a specific protein called SIRT5 can help kill cancer cells and improve treatment results.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11005706

• Understanding how Ewing sarcoma affects gene transcription

  This study is looking at how a specific protein linked to Ewing sarcoma affects how genes work in cells, with the hope of finding new ways to treat this type of bone cancer.

  NIH research University of Arizona · Tucson, United States · NIH-10983780

• Targeting a specific protein to improve treatment for Ewing sarcoma

  This study is looking at a specific protein called PAK4 that is linked to worse outcomes in kids and young adults with Ewing sarcoma, and it aims to find new treatments that can help improve their chances of recovery.

  NIH research Emory University · Atlanta, United States · NIH-10980926

• A 3D platform to study how Ewing sarcoma spreads to bones

  This study is looking at how Ewing sarcoma, a bone cancer that affects kids, spreads to bones and trying to find out what makes it worse, using a special lab setup that mimics bone to learn more about the cancer's behavior and the genes involved.

  NIH research Georgetown University · Washington, United States · NIH-10976090

• Understanding how DNA repair issues affect Ewing sarcoma in children and adolescents

  This study is looking at how problems with repairing DNA might lead to Ewing sarcoma, a type of cancer that affects kids and teens, to help find better ways to treat and understand the disease.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-10931447

• Targeting specific sugars on Ewing Sarcoma cells to improve treatment outcomes

  This study is testing a new treatment for Ewing sarcoma, a type of bone cancer that mostly affects kids and young adults, by using special immune cells that can better find and attack the cancer cells.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-10931390

• Investigating how Caveolin-1 influences Ewing Sarcoma cell behavior

  This study is looking at how a protein called Caveolin-1 affects the way Ewing Sarcoma cells, a type of cancer that mostly affects kids, adapt and grow in their environment, which could help us understand why this cancer can be tough to treat.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10929361

• Targeting the immune response to treat Ewing Sarcoma

  This study is exploring new treatments for Ewing Sarcoma, a type of bone cancer that mainly affects kids and young adults, by using the immune system to help it recognize and fight the cancer cells more effectively.

  NIH research Stanford University · Stanford, United States · NIH-10927350

• Understanding how EWS-FLI1 oncogene affects cell growth in Ewing sarcoma

  This study is looking at how a specific gene in Ewing sarcoma cells helps them grow uncontrollably by avoiding the usual ways that cells fix their damaged DNA, and it hopes to find new treatment options that could help patients with this type of bone cancer.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-10894628

• Identifying a specific protein linked to Ewing sarcoma in children and young adults

  This study is looking at a protein called LIPI to see how it affects Ewing sarcoma, a cancer that mostly impacts kids and young adults, with the hope of finding new ways to use the immune system to treat this tough disease.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10883632

• Investigating how proteoglycans affect signaling in Ewing sarcoma

  This study is looking at how certain proteins affect the growth of Ewing sarcoma, a type of bone cancer, by using zebrafish to see how cancer cells behave in a living creature, which could help find new ways to treat this disease.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-10873703

Related topics

Quick answers

How many Ewing Sarcoma clinical trials are recruiting right now?

40, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (23 trials), France (6 trials), China (6 trials), Italy (5 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 13, Phase 2: 8, Phase 1/2: 7, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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