Recovery and quality of life after limb-sparing surgery for soft tissue sarcoma
Body Image, Health-related Quality of Life, and Function After Soft Tissue Sarcoma Resection
This project will see how body image, quality of life, walking ability, and joint and muscle function are in people who had limb-sparing surgery for localized soft tissue sarcoma of an arm or leg.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Locations | 1 site (Amsterdam) |
| Trial ID | NCT06962072 on ClinicalTrials.gov |
What this trial studies
This is a cross-sectional follow-up of patients who underwent surgical resection for non-metastatic extremity soft tissue sarcoma at Amsterdam UMC between 2010 and 2021. Participants complete questionnaires, a physical exam, and objective tests including 3D gait analysis, a 6-minute walk test with gas analysis, muscle strength testing, and MRI comparisons to measure muscle-volume change. The study links these functional and structural measures to patient-reported body image, health-related quality of life, activity limitations, and pain. Researchers will also compare outcomes between patients treated with and without radiotherapy and explore factors such as ethnicity that may influence recovery.
Who should consider this trial
Good fit: Adults who had primary non-metastatic extremity soft tissue sarcoma removed at Amsterdam UMC between 2010 and 2021 and who can attend one or two on-site visits at the Amsterdam UMC (AMC) are the intended participants.
Not a fit: People whose cancer was not treated at Amsterdam UMC, who have active metastatic disease, or who cannot complete the required walking tests are not eligible or will not contribute to some functional measures and are therefore less likely to benefit from the study's findings.
Why it matters
Potential benefit: If successful, the findings could identify common functional deficits and body-image concerns and guide more personalized rehabilitation and follow-up care to improve long-term quality of life.
How similar studies have performed: Prior observational studies have shown lasting functional and body-image issues after limb-sparing resections, but combining detailed 3D gait analysis, gas analysis during a 6-minute walk, and MRI-based muscle-volume comparison is less common.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Treated with surgical resection for primary non-metastatic extremity STS at the Amsterdam UMC between 2010-2021. * Being able to visit the Amsterdam UMC, location AMC once or twice. * Pregnant patients must agree to be scheduled 5 months after their pregnancy ends. Exclusion Criteria: * Patients who cannot maintain 6 minutes of walking will be excluded from the 6-minute walk test.
Where this trial is running
Amsterdam
- Amsterdam UMC — Amsterdam, Netherlands (Recruiting)
Study contacts
- Study coordinator: Floortje G.M. Verspoor, MD/PhD
- Email: f.g.verspoor@amsterdamumc.nl
- Phone: +310205669111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.