Developing targeted therapies for soft tissue sarcoma
Official title: SPORE in Soft Tissue Sarcoma
Funded at Sloan-Kettering Inst Can Research · NIH-10848812 · Data updated 2026-11-12
This study is looking for better ways to treat soft tissue sarcoma by focusing on the unique genetic changes in this cancer, and it will involve both adults and children to find out what works best.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2018 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,375,406 |
| NIH project number | 2P50CA217694-06A1 |
| Project ID | NIH-10848812 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with soft tissue sarcoma, both adults and children.
✕Less likely to help
Patients with other types of cancer or those who do not have soft tissue sarcoma may not benefit from this research.
What this research studies
This research aims to reduce the impact of soft tissue sarcoma by creating therapies that target specific genetic and molecular changes associated with different types of this cancer. The team will investigate the underlying mechanisms that lead to sarcoma development and resistance to existing treatments. They will also validate new treatment targets through clinical trials involving both adults and children, utilizing a large database of patient outcomes and biological samples collected over decades.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with soft tissue sarcoma.
How similar studies have gone: Previous research has shown promise in developing targeted therapies for various cancers, indicating that this approach could be effective for soft tissue sarcoma as well.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Singer, Samuel — Sloan-Kettering Inst Can Research
- Study coordinator: Singer, Samuel
Related research
Other NIH-funded projects on the same topics.
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SPORE in Soft Tissue Sarcoma: targeted therapies and biomarkers to help patients
A big research effort at a major cancer center aims to develop targeted treatments and biomarkers to improve outcomes for people with soft tissue sarcoma.
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Ultra-steerable ultrasound therapy for soft tissue sarcoma
A new ultrasound device is being developed to non-invasively shrink or remove soft tissue sarcomas while protecting nearby nerves, blood vessels, and bones.
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Robotic ultrasound system to non-invasively remove soft tissue sarcoma
A robotic ultrasound approach aims to precisely destroy soft tissue sarcoma tumors without open surgery for people with large or hard-to-reach tumors.
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Boosting NK-cell therapy for soft tissue sarcoma using a dog model
This project combines an antibody that soaks up a tumor-made immune blocker with natural killer (NK) cell therapy to help dogs and, eventually, people with soft tissue sarcoma fight their tumors.
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Targeted treatments for soft tissue sarcoma
This project is testing targeted drugs and immunotherapies for people with soft tissue sarcoma, including adults and children.
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Enhancing cancer treatment using natural killer cells in dogs with soft tissue sarcoma
This study is looking at a new way to help treat soft tissue sarcoma in dogs by using special immune cells called natural killer cells, along with a targeted antibody, to make the treatment more effective and hopefully improve outcomes for our furry friends.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.