Using ultrasound to non-invasively destroy soft tissue sarcomas
Official title: Ultrasound-guided robotic histotripsy array system for non-invasive precise and complete ablation of soft tissue sarcoma
Funded at Purdue University · NIH-11031357 · Data updated 2026-11-12
This study is testing a new, gentle way to treat soft tissue sarcomas using focused ultrasound, which aims to destroy the tumors without harming nearby important structures, and it's designed to help improve the treatment experience and quality of life for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | June 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $214,043 |
| NIH project number | 5R21EB035278-03 |
| Project ID | NIH-11031357 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be patients diagnosed with soft tissue sarcomas, particularly those with large tumors that are difficult to treat with conventional methods.
✕Less likely to help
Patients with non-sarcoma tumors or those whose tumors are too small or not suitable for ablation may not benefit from this research.
What this research studies
This research investigates a new method called histotripsy, which uses focused ultrasound to non-invasively destroy soft tissue sarcomas while preserving surrounding critical structures like nerves and blood vessels. The approach aims to improve treatment outcomes for patients with these aggressive tumors, which often require debilitating multi-modal therapies. By utilizing real-time imaging feedback, the researchers hope to enhance the precision and effectiveness of tumor ablation, potentially leading to better quality of life for patients. The team has previously shown that this method can safely partially ablate tumors in dogs, and now seeks to adapt it for human use.
Why it matters
Potential benefit: If successful, this research could provide a safer, more effective treatment option for patients with soft tissue sarcomas, reducing the need for invasive surgeries and improving overall quality of life.
How similar studies have gone: Previous studies have shown success with histotripsy in veterinary applications, indicating potential for similar outcomes in human patients, although this specific application is novel.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Klahn, Shawna — Purdue University
- Study coordinator: Klahn, Shawna
Related research
Other NIH-funded projects on the same topics.
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Ultra-steerable ultrasound therapy for soft tissue sarcoma
A new ultrasound device is being developed to non-invasively shrink or remove soft tissue sarcomas while protecting nearby nerves, blood vessels, and bones.
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Robotic ultrasound system to non-invasively remove soft tissue sarcoma
A robotic ultrasound approach aims to precisely destroy soft tissue sarcoma tumors without open surgery for people with large or hard-to-reach tumors.
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Non-invasive treatment for soft tissue sarcoma using ultrasound technology
This study is testing a new ultrasound treatment that gently breaks down tough tumors in soft tissues, making it easier for patients with hard-to-reach sarcomas to manage their cancer without needing surgery.
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SPORE in Soft Tissue Sarcoma: targeted therapies and biomarkers to help patients
A big research effort at a major cancer center aims to develop targeted treatments and biomarkers to improve outcomes for people with soft tissue sarcoma.
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Boosting NK-cell therapy for soft tissue sarcoma using a dog model
This project combines an antibody that soaks up a tumor-made immune blocker with natural killer (NK) cell therapy to help dogs and, eventually, people with soft tissue sarcoma fight their tumors.
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Targeted treatments for soft tissue sarcoma
This project is testing targeted drugs and immunotherapies for people with soft tissue sarcoma, including adults and children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.