Using ultrasound to non-invasively destroy soft tissue sarcomas
Ultrasound-guided robotic histotripsy array system for non-invasive precise and complete ablation of soft tissue sarcoma
This study is testing a new, gentle way to treat soft tissue sarcomas using focused ultrasound, which aims to destroy the tumors without harming nearby important structures, and it's designed to help improve the treatment experience and quality of life for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-11031357 on NIH RePORTER |
What this research studies
This research investigates a new method called histotripsy, which uses focused ultrasound to non-invasively destroy soft tissue sarcomas while preserving surrounding critical structures like nerves and blood vessels. The approach aims to improve treatment outcomes for patients with these aggressive tumors, which often require debilitating multi-modal therapies. By utilizing real-time imaging feedback, the researchers hope to enhance the precision and effectiveness of tumor ablation, potentially leading to better quality of life for patients. The team has previously shown that this method can safely partially ablate tumors in dogs, and now seeks to adapt it for human use.
Who could benefit from this research
Good fit: Ideal candidates for this research would be patients diagnosed with soft tissue sarcomas, particularly those with large tumors that are difficult to treat with conventional methods.
Not a fit: Patients with non-sarcoma tumors or those whose tumors are too small or not suitable for ablation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer, more effective treatment option for patients with soft tissue sarcomas, reducing the need for invasive surgeries and improving overall quality of life.
How similar studies have performed: Previous studies have shown success with histotripsy in veterinary applications, indicating potential for similar outcomes in human patients, although this specific application is novel.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Klahn, Shawna — Purdue University
- Study coordinator: Klahn, Shawna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.