Non-invasive treatment for soft tissue sarcoma using ultrasound technology
Ultrasound-guided Ultra-steerable Histotripsy Array System for Non-invasive treatment of Soft Tissue Sarcoma
This study is testing a new ultrasound treatment that gently breaks down tough tumors in soft tissues, making it easier for patients with hard-to-reach sarcomas to manage their cancer without needing surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11092722 on NIH RePORTER |
What this research studies
This research focuses on developing a new ultrasound-guided system that can non-invasively treat soft tissue sarcomas (STS), which are malignant tumors found in soft tissues. The approach utilizes histotripsy, a technique that uses ultrasound to liquefy tumor tissue without harming surrounding critical structures like nerves and blood vessels. By targeting the tumor directly, this method aims to shrink or debulk the cancer, potentially making surgery unnecessary or easier. The research is particularly relevant for patients whose tumors are difficult to remove surgically due to their location.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with soft tissue sarcomas, particularly those with tumors that are challenging to surgically remove.
Not a fit: Patients with soft tissue sarcomas that are already amenable to surgical resection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective treatment option for patients with soft tissue sarcomas.
How similar studies have performed: While histotripsy has been explored for various tumor types, its application specifically for soft tissue sarcomas is relatively novel and has not been extensively tested.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Xu, Zhen — University of Michigan at Ann Arbor
- Study coordinator: Xu, Zhen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.