Investigating the roles of specific genes in the development and spread of soft tissue sarcomas.
Official title: DISSECTING THE ROLES OF FAT1 AND NEAT1 IN SOFT TISSUE SARCOMA DEVELOPMENT AND METASTASIS USING NOVEL IN VIVO SARCOMA MODELS
Funded at Providence Health & Services - Oregon · NIH-10908374 · Data updated 2026-11-12
This study is looking at how specific genes might play a role in the growth and spread of soft tissue sarcomas, which are rare and tough tumors, to help find better treatment options for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Providence Health & Services - Oregon NIH-funded |
| Lab location | 1 site (Renton, United States) |
| Project start | September 7, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $162,000 |
| NIH project number | 5K22CA248849-03 |
| Project ID | NIH-10908374 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with soft tissue sarcomas or those at high risk for developing these tumors.
✕Less likely to help
Patients with other types of cancer or those without a diagnosis of soft tissue sarcoma may not benefit from this research.
What this research studies
This research focuses on understanding how certain genes, specifically Fat1 and NEAT1, contribute to the development and metastasis of soft tissue sarcomas (STSs), which are rare and aggressive tumors. By utilizing innovative in vivo models and advanced CRISPR technology, the research aims to identify genetic mutations that drive sarcoma initiation and progression. Patients may benefit from this research as it seeks to uncover new therapeutic targets and improve treatment strategies for STS, which currently have limited options.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for soft tissue sarcomas, potentially improving survival rates.
How similar studies have gone: Other research has shown promise in using CRISPR technology to identify cancer-driving genes, suggesting that this approach may yield valuable insights into soft tissue sarcomas.
Where this research is happening
-
Providence Health & Services - Oregon
Renton, United States Active
Researchers
- Principal investigator: Huang, Jianguo — Providence Health & Services - Oregon
- Study coordinator: Huang, Jianguo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.