Exploring genetic factors in retroperitoneal liposarcoma recurrences
Official title: Characterization of the Genomic Risk Underlying Retroperitoneal Liposarcoma
Run by Fox Chase Cancer Center · NCT06436846 · Data updated 2026-11-12
This study is trying to see if changes in the fat around a type of cancer called retroperitoneal liposarcoma can help explain why it comes back after treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Fox Chase Cancer Center Academic / other |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Status | Recruiting |
| Started | March 7, 2022 |
| Main results expected | June 30, 2027 |
| Study ends | August 1, 2027 |
| Registry record updated | May 31, 2024 |
| Trial ID | NCT06436846 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adult patients with histologically confirmed retroperitoneal liposarcoma who are scheduled for surgical resection.
✕Probably not a fit
Patients with prior surgical anatomy that complicates fat sampling in the retroperitoneum may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the biological mechanisms behind recurrences of retroperitoneal liposarcoma, a type of soft tissue sarcoma. It hypothesizes that normal-appearing retroperitoneal fat may contain genetic changes that increase the risk of future tumor development. To test this hypothesis, researchers will collect samples of retroperitoneal fat from areas near and distant from the primary tumor during standard surgical procedures. These samples will undergo genetic analysis to identify potential predisposing factors for liposarcoma recurrence.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of retroperitoneal liposarcoma, potentially reducing recurrence rates.
How similar studies have gone: While this approach is innovative, similar studies exploring genetic factors in tumor recurrence have shown promise in other cancer types.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (age ≥18 years). * Histologically confirmed retroperitoneal liposarcoma via preoperative biopsy, or cross-sectional imaging suspicious for liposarcoma with planned surgical resection * Will be undergoing surgical resection for treatment of primary or recurrent disease * Have provided informed consent to participate in this study Exclusion Criteria: • Prior surgical anatomy which makes sampling of remote areas of the retroperitoneum technically impossible or clinically undesirable for safety reasons
Where it's running
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Study coordinator: Anthony Villano, MD
- Email: anthony.villano@fccc.edu
- Phone: 215-728-3686
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.