Targeted treatments for soft tissue sarcoma
Official title: SPORE in Soft Tissue Sarcoma
Funded at Sloan-Kettering Inst Can Research · NIH-11181551 · Data updated 2026-11-12
This project is testing targeted drugs and immunotherapies for people with soft tissue sarcoma, including adults and children.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2018 |
| Project end | August 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $2,453,831 |
| NIH project number | 5P50CA217694-07 |
| Project ID | NIH-11181551 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people with soft tissue sarcoma (adult or pediatric) whose tumor type or molecular tests match available trials or targeted approaches.
✕Less likely to help
Patients without targetable tumor changes, those unable to travel to participating centers, or those in poor health may not benefit from the trials developed here.
What this research studies
You would be part of a program that links lab discoveries to patient care to find specific genetic, epigenetic, and signaling changes in sarcoma tumors. The team uses a 41-year database of nearly 15,000 sarcoma patients plus tumor and blood samples, cell lines, and patient-derived xenografts to discover drug targets and biomarkers. Promising targets are taken into the clinic and used to open clinical trials so patients with matching tumor types or molecular profiles can receive new therapies. The program also studies why some tumors resist targeted or immune treatments to try to improve responses.
Why it matters
Potential benefit: If successful, this work could lead to more personalized treatments that control tumors better and reduce harmful side effects.
How similar studies have gone: Some targeted drugs and immunotherapies have helped particular sarcoma subtypes, but many of the approaches in this program are novel and still under clinical testing.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Singer, Samuel — Sloan-Kettering Inst Can Research
- Study coordinator: Singer, Samuel
Related research
Other NIH-funded projects on the same topics.
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SPORE in Soft Tissue Sarcoma: targeted therapies and biomarkers to help patients
A big research effort at a major cancer center aims to develop targeted treatments and biomarkers to improve outcomes for people with soft tissue sarcoma.
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Ultra-steerable ultrasound therapy for soft tissue sarcoma
A new ultrasound device is being developed to non-invasively shrink or remove soft tissue sarcomas while protecting nearby nerves, blood vessels, and bones.
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Robotic ultrasound system to non-invasively remove soft tissue sarcoma
A robotic ultrasound approach aims to precisely destroy soft tissue sarcoma tumors without open surgery for people with large or hard-to-reach tumors.
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Boosting NK-cell therapy for soft tissue sarcoma using a dog model
This project combines an antibody that soaks up a tumor-made immune blocker with natural killer (NK) cell therapy to help dogs and, eventually, people with soft tissue sarcoma fight their tumors.
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Enhancing cancer treatment using natural killer cells in dogs with soft tissue sarcoma
This study is looking at a new way to help treat soft tissue sarcoma in dogs by using special immune cells called natural killer cells, along with a targeted antibody, to make the treatment more effective and hopefully improve outcomes for our furry friends.
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Non-invasive treatment for soft tissue sarcoma using ultrasound technology
This study is testing a new ultrasound treatment that gently breaks down tough tumors in soft tissues, making it easier for patients with hard-to-reach sarcomas to manage their cancer without needing surgery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.