Targeted treatments for soft tissue sarcoma
SPORE in Soft Tissue Sarcoma
This project is testing targeted drugs and immunotherapies for people with soft tissue sarcoma, including adults and children.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11181551 on NIH RePORTER |
What this research studies
You would be part of a program that links lab discoveries to patient care to find specific genetic, epigenetic, and signaling changes in sarcoma tumors. The team uses a 41-year database of nearly 15,000 sarcoma patients plus tumor and blood samples, cell lines, and patient-derived xenografts to discover drug targets and biomarkers. Promising targets are taken into the clinic and used to open clinical trials so patients with matching tumor types or molecular profiles can receive new therapies. The program also studies why some tumors resist targeted or immune treatments to try to improve responses.
Who could benefit from this research
Good fit: Ideal candidates are people with soft tissue sarcoma (adult or pediatric) whose tumor type or molecular tests match available trials or targeted approaches.
Not a fit: Patients without targetable tumor changes, those unable to travel to participating centers, or those in poor health may not benefit from the trials developed here.
Why it matters
Potential benefit: If successful, this work could lead to more personalized treatments that control tumors better and reduce harmful side effects.
How similar studies have performed: Some targeted drugs and immunotherapies have helped particular sarcoma subtypes, but many of the approaches in this program are novel and still under clinical testing.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Singer, Samuel — Sloan-Kettering Inst Can Research
- Study coordinator: Singer, Samuel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.