Using a special dye to guide surgery for sarcoma removal
Official title: Sarcoma Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography
Run by Mayo Clinic · NCT06409013 · Data updated 2026-11-12
This study is testing whether a special dye can help surgeons remove sarcomas more accurately by showing them where the cancer ends during surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | March 14, 2024 |
| Main results expected | March 30, 2027 |
| Study ends | March 30, 2027 |
| Registry record updated | August 4, 2026 |
| Trial ID | NCT06409013 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients aged 18 and older with biopsy-proven bone or soft tissue sarcoma who are scheduled for surgical resection.
✕Probably not a fit
Patients with chronic kidney disease or a history of anaphylaxis to dyes will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study evaluates the effectiveness of indocyanine green (ICG) dye and fluorescence technology during the surgical resection of bone and soft tissue sarcomas. Patients will receive ICG infusion prior to their scheduled surgery, and their medical records will be reviewed to assess the outcomes. The primary objective is to determine how well ICG can help confirm negative margins after tumor removal, potentially improving surgical precision and patient outcomes.
Why it matters
Potential benefit: If successful, this approach could lead to more effective tumor resections and better long-term outcomes for patients with sarcoma.
How similar studies have gone: Other studies have shown promising results using similar fluorescence-guided techniques in surgical oncology, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with biopsy-proven bone or soft tissue sarcoma undergoing resection Exclusion Criteria: * Chronic kidney disease * Anaphylaxis to dyes
Where it's running
-
Mayo Clinic in Rochester
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Matthew T. Houdek, M.D. — Mayo Clinic in Rochester
- Study coordinator: Clinical Trials Referral Office
- Email: mayocliniccancerstudies@mayo.edu
- Phone: 855-776-0015
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Preoperative Immunonutrition for bone and soft tissue sarcoma patients
This study tests whether a short course of an oral nutrition supplement before surgery can help patients with bone or soft tissue sarcomas recover better after major tumor-related surgery.
-
Assessing early psychiatric referral effects on mental health in sarcoma patients
This study tests whether getting early mental health support helps sarcoma patients feel less anxious and depressed while recovering from surgery.
-
Evaluating quality of life and functional outcomes in sarcoma patients after limb salvage surgery
This study looks at how limb salvage surgery affects the quality of life and daily functioning of people aged 18 to 95 who have had surgery for bone or soft tissue sarcoma in their legs.
-
Quality assessment of sarcoma care in Europe and Latin America
This study looks at how well patients with different types of sarcoma are treated in Europe and Latin America to see if care is better at expert centers and to find ways to improve outcomes.
-
New method to deliver chemotherapy directly into the lungs for sarcoma patients
This study is testing a new way to deliver chemotherapy directly into the lungs during surgery for sarcoma patients to see if it can better target hidden cancer cells and improve their outcomes.
-
68Ga-HX01 PET/CT Imaging in Soft Tissue Sarcoma patients
This study tests whether a 68Ga-HX01 injection can help PET/CT imaging better characterize soft tissue sarcoma in adults who have exhausted standard treatments or have no good options.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.