Condition

Osteosarcoma clinical trials and research

• 58Clinical trials
• 52NIH research projects
• 1New in 30 days
• 19Countries

Newest Osteosarcoma clinical trials

All recruiting trials (58)

• Fight Osteosarcoma with a European, evolving research platform from diagnosis to relapse

  A European platform trial in pediatric and young adult high-grade osteosarcoma will test Cabometyx as one treatment option while collecting tumor and blood samples to guide future strategies.

  Recruiting Phase 3 Gustave Roussy, Cancer Campus, Grand Paris · Aarhus and 76 other locations · NCT07871864

• Immunotherapy plus standard treatment for high-risk osteosarcoma in kids and young adults

  This study tests mifamurtide added to standard chemotherapy versus standard treatment with sorafenib to see if the combination helps patients with high-risk osteosarcoma.

  Recruiting Phase 2 Institute of Mother and Child, Warsaw, Poland · Warsaw, Mazovian · NCT07787429

• 68Ga-B7-H3 Nanobody PET Imaging in Osteosarcoma

  This study tests a new gallium-68 labeled B7-H3 nanobody to see if it can image osteosarcoma tumors more clearly.

  Recruiting Early Phase 1 Peking University First Hospital · Beijing, Beijing Municipality · NCT07774533

• Domatinostat with Sirolimus for relapsed or refractory sarcoma and osteosarcoma

  This study tests whether the cancer drugs domatinostat and sirolimus together can help adolescents and adults whose sarcoma or osteosarcoma has come back or stopped responding to standard therapy.

  Recruiting at 2 sites Phase 1/2 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida and 3 other locations · NCT07725380

• Neoantigen Vaccine SarVac With Tumor-Specific Lymphocytes Plus PD-1 Blocker for Advanced Sarcoma

  This trial tests a personalized cancer vaccine called SarVac, given with a PD-1 blocker, and possibly tumor-specific lymphocytes, to see if it is safe and can help people with advanced soft tissue or bone sarcoma.

  Recruiting Phase 1 Sun Yat-sen University · Guangzhou, Guangdong · NCT07648069

• Methionine-Reduced Diet in Solid Tumors (early-phase)

  A small pilot study will test whether a methionine-reduced diet can change blood levels in adults with various solid tumors who are receiving standard cancer therapy.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT07628634

• Cryoablation plus anti-PD-1 therapy for advanced soft tissue sarcoma

  This study tests whether freezing tumors and giving camrelizumab can help people with advanced soft tissue sarcoma after standard treatments have failed.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07602049

• Adaptive Proton Therapy for Pediatric Solid Tumors and Hodgkin Lymphoma

  This study tests a regular imaging approach to see if proton therapy plans for children with solid tumors or Hodgkin lymphoma should be updated during treatment.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07514819

• Apatinib plus liposomal irinotecan for refractory or metastatic osteosarcoma

  This trial tests whether combining the oral drug apatinib with intravenous liposomal irinotecan helps patients whose osteosarcoma has progressed after standard chemotherapy.

  Recruiting Phase 1/2 Peking University People's Hospital · Beijing · NCT07479732

• Gefitinib, trametinib, disulfiram, and sunitinib added to standard chemotherapy for metastatic osteosarcoma

  This study tests whether adding gefitinib, trametinib, disulfiram, and sunitinib to standard chemotherapy helps people with newly diagnosed metastatic osteosarcoma.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07477457

• Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

  This trial tests whether adding eflornithine (DFMO) as extra or maintenance therapy can improve survival for young people with Ewing sarcoma or osteosarcoma.

  Recruiting at 3 sites Phase 2 Milton S. Hershey Medical Center · Tampa, Florida and 2 other locations · NCT07321912

• Remote smartwatch monitoring of walking and daily function in bone cancer

  This study tests whether a smartwatch can track walking stability and daily activities to spot changes during treatment for people with osteosarcoma or metastatic bone disease.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07129226

• Using a targeted probe to improve surgery for osteosarcoma

  This study is testing a special probe to see if it can help doctors remove osteosarcoma tumors more completely during surgery.

  Recruiting Phase 1/2 Peking University People's Hospital · Beijing, Beijing Municipality · NCT06778603

• Using Trilaciclib with Chemotherapy for Osteosarcoma Treatment

  This study is testing if adding Trilaciclib to chemotherapy can help protect the bone marrow of patients with stage II/III classic osteosarcoma during treatment.

  Recruiting Phase 2 Peking University People's Hospital · Beijing, Beijing Municipality · NCT06714383

• Testing a new drug combination for treating relapsed or refractory sarcomas in adolescents and young adults

  This study is testing a new combination of drugs to see if it can help adolescents and young adults with tough-to-treat sarcomas feel better and improve their chances of recovery.

  Recruiting Phase 1/2 Dana-Farber Cancer Institute · Boston, Massachusetts and 2 other locations · NCT06709495

• Evaluating the safety and effectiveness of OMO-103 for advanced high-grade osteosarcoma

  This study is testing a new treatment called OMO-103 to see if it can safely help people with advanced high-grade osteosarcoma.

  Recruiting Phase 2 Vall d'Hebron Institute of Oncology · Barcelona · NCT06650514

• Imaging study using two antibody fragments in patients with solid tumors

  This study is testing two special antibody fragments in people with solid tumors to see how well they target cancer cells and how they move through the body.

  Recruiting Early Phase 1 Var2 Pharmaceuticals · Groningen, Provincie Groningen · NCT06645808

• Alpha/beta T‑Cell and B‑Cell Depletion plus Zoledronic Acid for Pediatric and Young Adult Solid Tumors

  This study will try removing alpha/beta T cells and B cells from donor stem cell grafts and giving zoledronic acid to see if it helps children and young adults (6 months to 25 years) with relapsed or high‑risk solid tumors tolerate allogeneic transplant and reduce relapse.

  Recruiting Phase 1/2 University of Florida · Gainesville, Florida · NCT06625190

• Using silmitasertib with chemotherapy for relapsed solid tumors

  This study is testing a new drug called silmitasertib combined with chemotherapy to see if it helps people with relapsed solid tumors feel better and manage their cancer.

  Recruiting at 24 sites Phase 1/2 Milton S. Hershey Medical Center · Birmingham, Alabama and 23 other locations · NCT06541262

• XS-02 capsules in adults with advanced solid tumors

  This early-stage study tests XS-02 capsules to see if they are safe and tolerable and to get an early sense of how the drug behaves and works in adults with advanced solid tumors.

  Recruiting Phase 1 Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. · Beijing, Beijing Municipality · NCT06531486

• Using modified T cells to treat certain solid tumors in children and young adults

  This study is testing a new treatment using modified T cells to see if it can help children and young adults with tough-to-treat solid tumors.

  Recruiting Phase 1 Stanford University · Palo Alto, California · NCT06500819

• Combining Atezolizumab with Radiation and Surgery for Lung Recurrence of Osteosarcoma

  This study is testing whether combining a new immune therapy called Atezolizumab with radiation and surgery can help people with lung recurrences of osteosarcoma feel better and improve their chances of recovery.

  Recruiting Phase 1 Emory University · Atlanta, Georgia · NCT06492954

• Eflornithine (DFMO) plus AMXT 1501 for neuroblastoma, CNS tumors, and sarcomas

  This trial tests whether adding the oral drug AMXT 1501 to oral DFMO can help children and young adults (diagnosed by age 21) with relapsed or refractory neuroblastoma, ETMR, ATRT, Ewing sarcoma, osteosarcoma, or newly diagnosed DIPG.

  Recruiting at 14 sites Phase 1/2 Milton S. Hershey Medical Center · Birmingham, Alabama and 13 other locations · NCT06465199

• Using 3D printed models for planning bone tumor surgeries

  This study is testing if using 3D printed models can help doctors plan surgeries for bone tumors better than just using imaging alone.

  Recruiting at 3 sites Ricoh USA, Inc. · Oakland, California and 2 other locations · NCT06387485

• Surgical removal of osteosarcoma tumors before chemotherapy

  This study is testing if removing osteosarcoma tumors from the arms or legs before starting chemotherapy helps patients recover better and improves how well they can use their limbs.

  Recruiting Montefiore Medical Center · The Bronx, New York · NCT06384404

• Assessing long-term effects of fibular graft donor site

  This study is looking at how the leg where a bone graft was taken from feels and works years after the surgery, to see if there are any long-term problems compared to the other leg.

  Recruiting Assiut University · Asyut · NCT06324916

• Using Cytalux for better cancer surgery in children

  This study is testing if a special imaging agent called Cytalux can help doctors find and remove lung tumors more effectively during surgery in children with cancer.

  Recruiting Phase 1 Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT06235125

• Using cabozantinib with ifosfamide to treat Ewing's sarcoma and osteosarcoma

  This study is testing if a new combination of cabozantinib and high-dose ifosfamide can help children and young adults with Ewing's sarcoma and osteosarcoma that hasn't responded to previous treatments.

  Recruiting at 4 sites Phase 1 Children's Hospital of Philadelphia · San Francisco, California and 3 other locations · NCT06156410

• Treatment for resectable pulmonary osteosarcoma using immunotherapy and radiotherapy

  This study is testing a new treatment that combines immunotherapy and radiation before surgery to see if it helps patients with operable lung cancer caused by osteosarcoma.

  Recruiting Phase 2 Ruijin Hospital · Shanghai, Shanghai Municipality · NCT06114225

• Using organoids to predict chemotherapy response in osteosarcoma

  This study is trying to see how well different chemotherapy drugs work on osteosarcoma by testing them on tiny lab-grown versions of the tumors.

  Recruiting Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT06064682

• Comparing single vs double beam proton therapy for certain tumors

  This study is testing whether using one beam of proton therapy is just as effective and safer than using two beams for patients with certain types of tumors.

  Recruiting Centre Antoine Lacassagne · Nice · NCT06029218

• Observing local relapse in patients with high-grade osteosarcoma

  This study looks at patients with high-grade osteosarcoma who had a local relapse after treatment to see what patterns and outcomes are common.

  Recruiting at 2 sites Istituto Ortopedico Rizzoli · Bologna, BO and 1 other locations · NCT06017518

• HS-20093 treatment for patients with relapsed or refractory osteosarcoma and other sarcomas

  This study is testing a new treatment called HS-20093 to see if it can help patients with relapsed or hard-to-treat osteosarcoma and other types of sarcomas feel better.

  Recruiting at 11 sites Phase 2 Hansoh BioMedical R&D Company · Beijing and 10 other locations · NCT05830123

• Personalized home exercise program for patients with bone tumors after surgery

  This study tests whether a personalized home exercise program helps patients with bone tumors recover better after surgery and chemotherapy.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT05779670

• Investigating afamitresgene autoleucel for pediatric cancers

  This study is testing a new treatment called afamitresgene autoleucel to see if it can help children and young adults with certain advanced cancers that have specific genetic markers.

  Recruiting at 10 sites Phase 1/2 USWM, LLC (dba US WorldMeds) · Palo Alto, California and 9 other locations · NCT05642455

• Assessing the safety and effectiveness of vactosertib for osteosarcoma

  This study is testing a new drug called vactosertib to see if it is safe and effective for treating osteosarcoma in teenagers and adults whose cancer has come back or is hard to treat.

  Recruiting at 7 sites Phase 1/2 MedPacto, Inc. · Cleveland, Ohio and 6 other locations · NCT05588648

• Exploring a new cancer treatment using PeptiCRAd-1 and checkpoint inhibitors

  This study is testing a new cancer treatment that combines a special virus with immune therapy to see if it can help people with advanced cancer who haven't responded to other treatments.

  Recruiting at 2 sites Phase 1 Valo Therapeutics Oy · Frankfurt and 6 other locations · NCT05492682

• Using GnRHa to protect fertility during chemotherapy for young women

  This study is testing if a hormone treatment can help young women keep their ability to have children while they undergo chemotherapy for cancer.

  Recruiting at 4 sites Phase 3 Karolinska University Hospital · Gothenburg and 16 other locations · NCT05328258

• Comparing two surgical methods for lung cancer in osteosarcoma patients

  This study is testing whether open chest surgery or a less invasive approach is better for helping osteosarcoma patients with lung cancer live longer and feel less pain after surgery.

  Recruiting at 210 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 232 other locations · NCT05235165

• Using AOH1996 to treat hard-to-treat solid tumors

  This study is testing a new drug called AOH1996 to see if it is safe and effective for people with hard-to-treat solid tumors like certain sarcomas and ovarian cancer.

  Recruiting at 2 sites Phase 1 City of Hope Medical Center · Scottsdale, Arizona and 2 other locations · NCT05227326

• Combining pembrolizumab and cabozantinib for advanced sarcomas

  This study is testing if combining two treatments, pembrolizumab and cabozantinib, can help people with advanced types of sarcoma feel better and improve their condition.

  Recruiting at 6 sites Phase 2 Institut Bergonié · Bordeaux and 9 other locations · NCT05182164

• Investigating early ageing in young cancer patients during treatment

  This study is trying to see how cancer treatment affects early aging and heart health in young adults aged 18-39 who are undergoing therapy for cancer.

  Recruiting University Medical Center Groningen · Groningen · NCT05062707

• Using HER2 CAR T cells with checkpoint inhibitors for advanced sarcoma

  This study is testing a new treatment that combines personalized CAR T cells with immune boosters to see if it helps people with advanced HER2-positive sarcoma.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT04995003

• B7-H3 CAR T-cell therapy for pediatric solid tumors

  This study is testing a new type of immune therapy using specially modified T cells to see if it can help children with tough-to-treat solid tumors.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04897321

• Using Metformin to Prevent Relapse in Bone Sarcoma Patients

  This study is testing if Metformin can help prevent relapse in patients with osteosarcoma and Ewing sarcoma who are at high risk of their cancer coming back.

  Recruiting Phase 2 Istituto Ortopedico Rizzoli · Bologna · NCT04758000

• Using regorafenib with supportive care for patients with high-grade bone sarcomas

  This study is testing if the drug regorafenib, along with supportive care, can help people aged 12 and older with high-grade bone sarcomas who haven't fully responded to standard treatment.

  Recruiting at 8 sites Phase 2 Centre Leon Berard · Besançon and 15 other locations · NCT04698785

• Trastuzumab Deruxtecan for Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor

  This study tests trastuzumab deruxtecan in children and young adults whose osteosarcoma, Wilms tumor, or desmoplastic small round cell tumor has come back or resisted treatment to see if the drug can help shrink tumors.

  Recruiting at 21 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 31 other locations · NCT04616560

• Improving outcomes for patients with osteosarcoma

  This study is trying to gather information and samples from people with osteosarcoma to better understand the disease and find ways to improve treatment and outcomes.

  Recruiting at 22 sites University College, London · London, Greater London and 21 other locations · NCT04132895

• Using Regorafenib to Maintain Treatment Benefits After Initial Therapy for Bone Sarcomas

  This study is testing if the drug regorafenib can help people with bone sarcomas stay cancer-free longer after their initial treatment.

  Recruiting at 12 sites Centre Leon Berard · Besançon and 15 other locations · NCT04055220

• Using Abemaciclib to treat certain bone and soft tissue sarcomas with specific genetic alterations

  This study is testing if the drug Abemaciclib can help people with certain types of bone and soft tissue sarcomas that have specific genetic changes.

  Recruiting at 4 sites Phase 2 Medical College of Wisconsin · Jacksonville, Florida and 3 other locations · NCT04040205

• Combining Losartan and Sunitinib for Osteosarcoma Treatment

  This study is testing if combining two medications, Losartan and Sunitinib, can help people aged 10 and older with osteosarcoma that hasn't responded to previous treatments.

  Recruiting at 4 sites Phase 1 University of Colorado, Denver · Los Angeles, California and 3 other locations · NCT03900793

• CAR T-Cell Therapy for Neuroblastoma and Osteosarcoma

  This study is testing a new CAR T-cell therapy for children with hard-to-treat neuroblastoma and osteosarcoma to see if it can better fight their cancer while keeping them safe from serious side effects.

  Recruiting Phase 1 UNC Lineberger Comprehensive Cancer Center · Atlanta, Georgia and 1 other locations · NCT03721068

• Comparing imaging techniques for diagnosing tumors in children and young adults

  This study is testing which imaging method works best for diagnosing tumors in children and young adults by comparing MR imaging, PET/MR imaging, and PET/CT imaging.

  Recruiting Stanford University · Palo Alto, California · NCT03458520

• Evaluating recovery and function after bone cancer surgery

  This study looks at how well people recover and regain function after surgery for bone cancer, including the use of bone grafts or artificial devices, over three years.

  Recruiting at 5 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 4 other locations · NCT03442465

• Transplantation with modified stem cells and Zoledronate for pediatric cancers

  This study is testing a new way to use modified stem cells and a drug called Zoledronate to see if it can safely help children with tough-to-treat cancers.

  Recruiting Phase 1 University of Wisconsin, Madison · Madison, Wisconsin · NCT02508038

• Combination therapy with MM-398 liposome irinotecan and cyclophosphamide in children with solid tumors

  This study tests whether a higher dose of MM-398 (liposomal irinotecan) can be given safely when used with cyclophosphamide in children with recurring or treatment-refractory solid tumors.

  Recruiting at 5 sites Phase 1 South Plains Oncology Consortium · Cincinnati, Ohio and 4 other locations · NCT02013336

• Effects of dexrazoxane on heart health in cancer survivors

  This study tests if the drug dexrazoxane can help protect the heart health of cancer survivors who had leukemia, lymphoma, or osteosarcoma.

  Recruiting at 62 sites Children's Oncology Group · Birmingham, Alabama and 78 other locations · NCT01790152

• Collection of data on orthopaedic conditions and rehabilitation

  This study collects information from patients with bone and muscle conditions at the University of Florida to help improve understanding and treatment of these issues.

  Recruiting University of Florida · Gainesville, Florida · NCT00411060

NIH-funded research (newest 40 of 52)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how bone cancer cells rely on certain pathways to grow in childhood osteosarcoma

  This grant studies how specific cancer-related pathways in bone-forming cells drive osteosarcoma in children, with the aim of finding better treatments.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11592245

• Histotripsy + immune boost to fight osteosarcoma

  A new treatment idea combines a precise non-surgical ultrasound method with an immune-boosting compound to help fight bone cancer in people and dogs.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11592083

• Genomically guided drug testing for osteosarcoma in patient-derived models

  A precision approach tests new drugs on osteosarcoma models created from patients to find promising treatments for kids and teens.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11537822

• New ways to stop osteosarcoma from spreading

  Researchers are testing new approaches to block how osteosarcoma spreads, with the aim of improving survival for children and adults with metastatic disease.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11444426

• Targeting OST Redundancy to Treat Osteosarcoma

  A study in people with advanced bone cancer to see if new OST-targeting drugs can slow or stop tumor growth.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11426739

• Focal Adhesion Kinase inhibitor to block osteosarcoma spread to the lungs

  A cancer treatment plan tests whether blocking a specific cell signal can stop osteosarcoma from growing and spreading to the lungs in kids and young people.

  NIH research Colorado State University · Fort Collins, United States · NIH-11415785

• Canine osteosarcoma immunity boost from hyperactivated dendritic cells

  A study tests a way to spark a strong anti-tumor immune response in dogs with bone cancer using highly activated immune cells.

  NIH research Tufts University Boston · Boston, United States · NIH-11404979

• Antibody-drug conjugates for pediatric osteosarcoma therapy

  A grant to develop targeted antibody-drug conjugates aimed at treating pediatric osteosarcoma by delivering cancer drugs directly to tumor cells.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11397833

• Osteosarcoma in dogs: understanding natural disease and immune environment to guide human treatments

  A study in pet dogs with naturally occurring bone cancer will map how the disease progresses and how the immune system interacts with tumors to inform future human trials.

  NIH research University of California at Davis · Davis, United States · NIH-11392498

• Osteosarcoma: Targeting CD24 to Stop Lung Metastasis

  A study explores a CD24-targeting antibody to help the immune system fight osteosarcoma that has spread to the lungs.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11358016

• Alpha-emitter therapy for osteosarcoma in teens and young adults

  A Johns Hopkins study will test a targeted alpha-radiation therapy (225Ac-Hu3F8) to treat osteosarcoma in teens and young adults by using an antibody that homes in on GD2 to kill cancer cells.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11348895

• Targeting how metastatic osteosarcoma cells take hold in the lungs

  This grant explores why certain osteosarcoma cells survive in the lungs and how this “anchor” group helps cancer spread, with the goal of preventing metastasis in children.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11335718

• Non-invasive ultrasound treatment to remove osteosarcoma bone tumors

  They are developing an image-guided ultrasound device to non-surgically break up osteosarcoma tumors in children and adults.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11321614

• How p53 and Notch genes drive childhood bone cancer (osteosarcoma)

  This project looks at how changes in the p53 and Notch genes in bone-forming cells contribute to osteosarcoma in children.

  NIH research Sanford Research/usd · Sioux Falls, United States · NIH-11309653

• Building realistic 3D bone tumor models to find better treatments

  Making 3D bone-tumor models to help find more effective drug combinations for children and young adults with osteosarcoma.

  NIH research Stanford University · Stanford, United States · NIH-11308655

• Epigenetic subtypes of osteosarcoma linked to chemo resistance and spread

  This project looks for different molecular subtypes of osteosarcoma in children and young adults to understand why some tumors resist chemotherapy or spread.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11305266

• Targeting MYC-driven osteosarcoma

  Researchers will look for weak spots in osteosarcoma tumors that have extra copies of the MYC gene to guide better treatments for children and teens.

  NIH research Emory University · Atlanta, United States · NIH-11289348

• Boosting the immune response against canine osteosarcoma using specialized immune cells

  This study is looking at ways to boost the immune system in dogs with osteosarcoma by using special treatments that help important immune cells work better, with the hope that what they learn can also help improve cancer treatments for people.

  NIH research Tufts University Boston · Boston, United States · NIH-11255126

• Blocking Dkk‑1 to fight osteosarcoma using insights from pet dogs

  A gene‑targeting antisense drug that blocks the protein Dkk‑1 is being developed to help people (including children) with osteosarcoma.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11251622

• Stopping osteosarcoma from spreading to the lungs with RNA-packed nanoparticles

  An RNA-based nanoparticle vaccine aims to train the immune system to stop or shrink lung metastases in children and adults with osteosarcoma.

  NIH research University of Florida · Gainesville, United States · NIH-11178517

• Bone cancer in pet dogs and how it mirrors human disease

  This project looks at how naturally occurring bone cancer in pet dogs behaves—clinically, molecularly, and immunologically—to guide better trials and outcome measures for dogs and people.

  NIH research University of California at Davis · Davis, United States · NIH-11141121

• Understanding the genetic differences in osteosarcoma to improve treatment options

  This study is looking at different types of osteosarcoma, a bone cancer that mostly affects kids and young adults, to find out how their genes work and how they might respond to treatments, so we can create better, more personalized therapies for patients.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11133588

• Stopping Osteosarcoma from Spreading

  This project looks for new ways to stop osteosarcoma, a type of bone cancer common in young people, from spreading to other parts of the body.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11127707

• Understanding and stopping osteosarcoma spread

  This research aims to understand how osteosarcoma cancer cells spread to the lungs and find new ways to stop them.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11126581

• Finding new treatments for bone cancer using patient-derived models

  This work looks for new ways to treat osteosarcoma, a type of bone cancer, especially in children and young adults, by testing promising new medicines.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11121898

• Understanding how specific genes contribute to the development of bone cancer in children

  This study is looking at how certain genes, especially p53 and Rb, affect the growth of osteosarcoma, a serious bone cancer that mainly affects kids, to help find better treatments for patients.

  NIH research Sanford Research/usd · Sioux Falls, United States · NIH-11108960

• Using targeted alpha-emitter therapy to treat osteosarcoma in young patients

  This study is testing a new way to treat osteosarcoma, a type of bone cancer that mainly affects teens and young adults, by using a special therapy that targets cancer cells directly while protecting healthy tissue, and it's being done first in dogs to make sure it's safe and effective before trying it in people.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11093461

• Developing a non-invasive treatment for bone tumors using ultrasound technology

  This study is testing a new ultrasound device that gently breaks down bone cancer tumors without surgery, making it a safer option for both kids and adults with osteosarcoma.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11082420

• Creating 3D models of osteosarcoma to improve drug discovery

  This study is creating special 3D models of osteosarcoma, a type of bone cancer that mainly affects kids and young adults, to help us learn more about how the cancer works and find better treatment options.

  NIH research Stanford University · Stanford, United States · NIH-11057512

• Understanding and targeting features of Myc-driven Osteosarcoma

  This study is looking at how certain genetic changes in Myc-driven osteosarcoma, a type of bone cancer that often affects kids, can impact how the tumor grows and responds to treatment, with the hope of finding better ways to help patients fight this tough disease.

  NIH research Emory University · Atlanta, United States · NIH-11049430

• Improving detection of metastatic osteosarcoma during surgery

  This study is testing a new way to help surgeons find and remove hard-to-see cancer spots in kids and teens with metastatic osteosarcoma by using special imaging tools during surgery.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11031944

• Targeting a specific protein to treat osteosarcoma in children using a therapy developed with dogs

  This study is testing a new treatment for osteosarcoma, a type of bone cancer that affects kids, by using a special drug to block a protein that helps tumors grow, and it will also look at how well this treatment works in dogs with the same cancer to help improve options for children in the future.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11031821

• Understanding and targeting a specific type of bone cancer in children and adolescents

  This study is looking at how a common bone cancer called osteosarcoma develops in kids and teens, especially those with a specific gene change, to find better ways to treat it and help improve survival rates.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11013830

• Exploring new treatment methods for osteosarcoma using focused ultrasound

  This study is exploring a new way to treat osteosarcoma, a tough bone cancer, using a special ultrasound technique that breaks down tumors, and it's designed for dogs with this condition to help them have better treatment results and fewer side effects.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-10998439

• Understanding how osteosarcoma spreads to the lungs

  This study is looking at how bone cancer, called osteosarcoma, spreads to the lungs, and it aims to find new ways to stop this from happening, which could help patients get better treatments for their cancer.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10995632

• Targeting TGF-beta signaling to treat osteosarcoma

  This study is looking at how a new drug called TEW-7197 can help treat osteosarcoma, a type of bone cancer that can spread to the lungs, by blocking a specific signaling pathway, and it aims to find out if this can improve the way the cancer grows and how the immune system responds.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10991388

• Identifying genetic markers to improve treatment for pediatric osteosarcoma

  This study is looking to create a blood test for kids and young adults with osteosarcoma that can help doctors understand how serious the cancer is and how well different treatments might work for each patient, so they can tailor the treatment to be just right for them.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10983313

• Targeting a specific signaling pathway to treat high-risk osteosarcoma

  This study is looking at a new way to help people with high-risk osteosarcoma, a tough type of bone cancer, by testing a special medicine called Tegavivint that aims to stop the cancer from growing and spreading while keeping healthy cells safe.

  NIH research Emory University · Atlanta, United States · NIH-10943147

• New treatment for osteosarcoma using an immunomodulating peptide

  This study is testing a new treatment made from a special peptide that could help kids and teens with osteosarcoma, a type of bone cancer, by boosting their immune response and possibly stopping the cancer from spreading, offering hope for better outcomes alongside current chemotherapy options.

  NIH research Pharmain Corporation · Bothell, United States · NIH-10931704

• Understanding how certain tumor cells survive and promote growth in osteosarcoma metastasis

  This study is looking at how certain tumor cells in osteosarcoma change when they reach the lungs, which helps them survive and grow, and it aims to find out if chemotherapy might be leaving these cells unharmed, potentially leading to more cancer later on.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-10916186

Related topics

Quick answers

How many Osteosarcoma clinical trials are recruiting right now?

58, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (33 trials), China (9 trials), Italy (5 trials), France (5 trials), Netherlands (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 14, Phase 2: 13, Phase 1/2: 9, Phase 3: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →