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Gynecologic Cancer clinical trials and research
As of November 12, 2026, Find a Trial lists 64 Gynecologic Cancer clinical trials that are recruiting, at sites in 18 countries (most in United States (26), Italy (11), Canada (9)). 2 were first registered in the last 30 days. By phase: Phase 2 (5), Phase 1 (3), Phase 3 (2), Phase 1/2 (1). The most active sponsors are Fondazione Policlinico Universitario Agostino Gemelli IRCCS (5), University of Utah (3), University Health Network, Toronto (3). There are also 17 NIH-funded research projects on Gynecologic Cancer, with $7.4 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 64Clinical trials
- 17NIH research projects
- 2New in 30 days
- 18Countries
Newest Gynecologic Cancer clinical trials
All recruiting trials (64)
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NMTCuff vs standard TOF monitoring during gynecologic oncology surgery
This study tests whether NMTCuff monitoring can better detect neuromuscular recovery than standard TOF monitoring in women undergoing laparoscopic gynecologic cancer surgery.
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Radiotherapy for gynecologic cancer with up to 10 metastatic sites
This registry follows adults with gynecologic cancer who have 1 to 10 active metastatic lesions and are treated with radiotherapy as part of routine care to see how such treatments work in real-world settings.
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Personalized supervised exercise program for adults with breast or gynecologic cancer
A small pilot study will test a supervised, personalized exercise program to see if it is safe, feasible, and acceptable for adults with a history of breast or gynecologic cancer.
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Cesium-131 brachytherapy to preserve organs in recurrent cervical or endometrial cancer
This study tests whether implanting small cesium-131 seeds can provide targeted radiation to vaginal recurrences of cervical or endometrial cancer in patients who previously had pelvic radiation, with the goal of preserving organs.
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National registry of endometrial cancer cases in Italy
This project will collect clinical and molecular information from adults treated for endometrial cancer at participating Italian oncology centers to see if a national database can improve understanding of outcomes and care.
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High-precision detection of leftover cancer using a liquid-biopsy platform (SHERLOCK)
This project will test whether sensitive blood and other fluid tests for circulating tumor DNA can find leftover cancer (minimal residual disease) in adults treated with curative intent for breast, lung, melanoma, gynecologic, or genitourinary cancers.
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Massage therapy feasibility for gynecologic cancer patients during infusion
This study tests whether it's feasible to run a massage therapy program for patients with gynecologic cancer who are receiving infusion treatments.
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Riluzole to prevent thinking and memory problems during chemotherapy
This pilot trial tests whether riluzole can prevent thinking and memory problems in adults with cancer receiving anthracycline- or platinum-based chemotherapy.
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Web app for reporting side effects during radiation therapy
This project will try a web app that lets people receiving radiation for breast, gynecologic, or urologic cancers report symptoms and quality of life so clinicians can spot problems earlier.
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7-day Via Shalva integrative retreat for breast and gynecologic cancer survivors
This pilot will try a 7-day integrative retreat called Via Shalva for breast and gynecologic cancer survivors to see if the program is feasible and whether participants show changes in symptoms, wearable physiological data, and biological markers versus matched controls.
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CARE Tool to help patients understand cancer care costs
This study will test a web-based CARE Tool that gives adults with gynecologic, prostate, lung, or colorectal cancer clear information about treatment costs, insurance, and resources to help with medical bills.
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Guided meditation during radiation for breast and gynecologic cancers
This project will test whether short guided meditations played during daily radiation can reduce anxiety for adults receiving radiation for breast or gynecologic cancer.
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Guarana for reducing fatigue in people with neuroendocrine or gynecologic cancers
We will test whether taking guarana can help reduce fatigue in adults with neuroendocrine tumors or gynecologic cancers.
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Health-Oriented Protocol for Epidermal Radiodermatitis
This study looks at how skin reactions from radiation therapy affect adults with head/neck or pelvic cancers and whether certain factors influence RID outcomes.
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Magnetic brain stimulation to reduce chemotherapy-related nerve pain in breast and gynecologic cancer survivors
This trial tries repetitive transcranial magnetic stimulation (rTMS) to see if it reduces chemotherapy-induced peripheral neuropathy pain in adult women treated for breast or gynecologic cancers.
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Molecular and cellular analysis of uterine lavage from gynecologic surgery
This will try a new uterine lavage catheter to collect samples from up to 50 adults having gynecologic surgery to see what cells are present.
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Florida ASCENT Program
This project will test whether combining the MyCarePulse EHR platform with ASCENT patient navigators helps adults with recent cancer diagnoses in Florida improve food security, diet quality, and confidence in healthy eating compared with standard care.
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Identifying cancer risk using digital and molecular markers
This study is trying to find new ways to predict the risk of developing different types of cancer, especially breast cancer, by looking at biological markers and lifestyle factors in both cancer patients and healthy people.
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Program to support patients with advanced gastrointestinal and gynecologic cancers
This study is testing a new support program to see if it can help people with advanced gastrointestinal and gynecologic cancers feel better and need less hospital care.
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High-frequency ultrasound during gynecologic cancer surgery to check lymph nodes and build radiomics data
We will test whether using high-frequency ultrasound during surgery can help doctors check lymph nodes in women having operations for ovarian, endometrial, cervical, or vulvar cancer.
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Using ultrasound to measure muscle mass in older women with gynecologic cancer to predict hospital stay length
This study is testing if using ultrasound to measure muscle mass in older women with gynecologic cancer can help predict how long they will stay in the hospital after surgery.
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Personalized exercise program for cancer patients
This study is testing a personalized exercise program and support group for women with gynecologic cancer to see if it helps them feel better during treatment.
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Using Belzutifan to treat recurrent clear cell ovarian carcinoma
This study is testing if a new targeted therapy called Belzutifan can help people with recurrent clear cell ovarian cancer feel better and manage their disease.
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Using brodalumab to treat immune-related side effects from cancer therapy
This study is testing if brodalumab can help cancer patients who are having immune-related side effects from their immunotherapy treatment feel better.
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Spatially fractionated radiation for gynecologic cancers
This will try spatially fractionated radiation after external beam therapy to control cervical cancer or pelvic recurrences in people who can't have standard brachytherapy.
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Evaluating fatigue and molecular mechanisms in cancer patients undergoing combined chemotherapy and radiation therapy
This study is testing how fatigue affects cancer patients getting both chemotherapy and radiation therapy, and whether certain genes and molecules are linked to how tired they feel during treatment.
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Using robotic ultrasound to evaluate lymph nodes in gynecological cancers
This study is testing a new robotic ultrasound method to see if it can help women with gynecological cancers check their lymph nodes during surgery, aiming to reduce the need for more invasive procedures.
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Using Riluzole to Help Breast Cancer Survivors with Cognitive Issues
This study is testing if the medication riluzole can help breast cancer survivors who are having trouble with thinking and memory feel better.
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Multidisciplinary assessment for supportive care in gynecological cancer patients
This study is testing whether a personalized care plan and support from a team of specialists can help women recovering from ovarian and endometrial cancers feel better compared to standard care.
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Comparing VC and PC ventilation effects during laparoscopic gynecologic surgery
This study is testing whether using volume control or pressure control ventilation during laparoscopic gynecologic surgery can improve breathing and recovery for patients.
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3D printed applicators for treating gynecologic cancers
This study is testing whether 3D-printed custom applicators can make radiation treatment more effective for patients with gynecologic cancers.
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Palliative radiotherapy for pelvic soft tissue tumors
This study is testing if giving fewer doses of palliative radiotherapy can help relieve symptoms and improve quality of life for patients with pelvic soft tissue tumors from gastrointestinal, urological, or gynecological cancers.
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Stress management for breast and gynecologic cancer patients in Vietnam
This study tests a new stress management program for breast and gynecologic cancer patients in Vietnam to see if it can help them feel better emotionally compared to standard care.
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Analyzing saliva for diagnosing gynecological conditions
This study is testing if analyzing saliva can help doctors diagnose gynecological conditions like endometriosis and ovarian cancer in both patients with symptoms and those without.
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Injecting engineered immune cells to treat advanced solid tumors
This study is testing a new treatment that uses specially modified immune cells taken from patients' tumors to see if it can help people with advanced cancers that haven't responded to other treatments.
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Advanced radiotherapy for gynecological cancer patients
This study looks at how advanced types of radiotherapy affect women with gynecological cancer to see how well they work and what side effects they might cause.
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CD70-targeted CAR-T treatment for advanced gynecologic cancer
This study is testing a new CAR-T treatment that targets CD70 to see if it can help people with advanced gynecologic cancers feel better and improve their outcomes.
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Using cryocompression to reduce nerve pain from chemotherapy in gynecologic cancer patients
This study is testing if using cold therapy with compression can help reduce nerve pain from chemotherapy in women with gynecologic cancer better than just cold therapy alone.
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Understanding frailty in gynecologic cancer patients to improve recovery
This study looks at how frailty affects recovery and quality of life in adults newly diagnosed with gynecologic cancer to see what factors might contribute to being frail.
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Nutritional support for gynecologic cancer patients undergoing chemotherapy
This study tests if adding a special nutritional supplement to the standard care can help women with gynecologic cancer undergoing chemotherapy maintain muscle mass and improve their treatment outcomes.
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Comparing robotic and traditional laparoscopic surgery for obese patients with early endometrial cancer
This study is testing whether robotic surgery works better than traditional laparoscopic surgery for morbidly obese patients with early endometrial cancer.
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High dose radiotherapy boost for gynecological cancers when brachytherapy isn't possible
This study tests if a high dose of a special type of radiation treatment can help control tumors in women with gynecological cancers who can't have brachytherapy, while also looking at any side effects they might experience.
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Using a smartphone brain-training app to reduce chemo‑brain in gynecologic cancer patients
This will test whether a mobile cognitive training app can reduce chemo‑brain symptoms in people with gynecologic cancers who are receiving chemotherapy.
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Assessing frailty to predict outcomes in older gynecologic cancer patients
This study is testing if checking for frailty before surgery can better predict recovery and complications for older women with gynecologic cancer compared to standard heart health checks.
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Observational study on rare gynecological cancers
This study is trying to learn more about rare gynecological cancers to improve treatment and care for patients facing these conditions.
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Observational study on outcomes of advanced pelvic cancer surgeries
This study looks at how well patients do after having complex surgeries for advanced pelvic cancer to see what challenges they face and how to improve their care.
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Mobile education for women undergoing gynecological cancer surgery
This study tests if mobile education can improve the quality of life for women having surgery for gynecological cancer compared to standard care.
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Using a chatbot to improve genetic risk assessment for hereditary cancer
This study is testing if a chatbot can help more patients at risk for hereditary cancer get recommended for genetic testing compared to regular care in a gynecology clinic.
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Combining Cabozantinib and Dostarlimab for Recurrent Gynecologic Carcinosarcoma
This study is testing if combining two drugs, Cabozantinib and Dostarlimab, can help people with recurrent gynecologic carcinosarcoma who have already had chemotherapy.
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Carbon ion radiation therapy for treating mucous melanomas in the female lower genital tract
This study is testing if carbon ion radiation therapy can help women with non-metastatic mucosal melanoma in the lower genital tract who can't have surgery, to see if it works better than standard treatments.
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Using ferric derisomaltose to improve recovery in gynecologic cancer surgery
This study is testing if an iron treatment can help women with gynecologic cancer surgery recover better by improving their iron levels and reducing the need for blood transfusions.
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Evaluating Proton Therapy for Tumors Previously Treated with Radiation
This study is testing a new type of radiation therapy called proton therapy to see if it can help people with tumors that have already been treated with radiation, while causing less harm to healthy tissues.
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Understanding cancer through genomic profiling and analytics
This study is trying to understand the genetic features of different types of cancer in people from a community healthcare system to improve screening and treatment options.
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Exploring the gut microbiome in gynecological cancer patients receiving immunotherapy
This study is trying to see how the gut bacteria of women with advanced gynecological cancer affects their response to immunotherapy treatment.
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Using 3D Ultrasound for Needle Guidance in Gynecological Cancer Treatment
This study is testing if using 3D ultrasound can help doctors place needles more accurately during radiation treatment for women with gynecological cancers.
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Using blood tests to analyze tumor DNA in breast and digestive cancers
This study is testing whether blood tests that look for tumor DNA can help improve treatment and monitoring for people with breast, digestive, and gynecologic cancers.
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Mindfulness practice for patients with endometrial and cervical cancer
This study is testing whether using a mindfulness app can help women with endometrial or cervical cancer feel less stressed and anxious before their surgery or treatment.
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Using stereotactic body radiotherapy for patients with rare oligometastatic cancers
This study is testing if adding a special type of targeted radiation therapy to standard treatment can help people with rare cancers that have spread to a few places live longer and feel better.
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Fertility preservation for women with endometrial cancer and hyperplasia
This study is testing a new surgery to help younger women with early-stage endometrial cancer or hyperplasia keep their ability to have children instead of needing a hysterectomy.
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Effects of Atezolizumab on Cancer Patients with Sensitive Tumor DNA or RNA
This study is testing if atezolizumab can help cancer patients with certain tumor types that show they might respond well to the treatment.
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Evaluating the impact of MR-guided radiation therapy on cancer treatment outcomes
This study is testing how using a special type of radiation therapy with real-time imaging can improve treatment results and quality of life for adults with cancer.
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Creating a database for cancer research and treatment
This study is creating a detailed database to help researchers understand different types of cancer better and improve treatments for patients.
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Examining biomarkers in gynecological cancers
This study is testing how certain biological markers in tumor and blood samples from women with gynecological cancers can help improve treatments and outcomes for patients.
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Research on biomarkers in ovarian cancer patients
This study is collecting blood and tissue samples from women with advanced ovarian cancer to see if certain markers can help doctors understand the disease better and make more informed treatment choices.
NIH-funded research (17)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Standardized, patient-centered treatment plans for breast and gynecologic cancer survivors facing sexual dysfunction and vaginal microbiome changes
A patient-friendly program tests personalized, non-hormonal treatment plans for sexual dysfunction in breast cancer survivors, guided by changes in the vaginal microbiome.
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Gynecologic cancer care: faster enrollment in targeted trials through molecular matching and better access to care
Aims to speed up enrollment in personalized gynecologic cancer trials by matching patients to targeted therapies and improving access to care.
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WNT4 and gynecologic cancer: a genetic link to therapy resistance and disparities
Researchers are studying how a gene variant called WNT4 may influence gynecologic cancers and contribute to differences in risk among populations, with the aim of improving future treatments.
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Virtual Mindful After Cancer program to improve sexual health for breast and gynecologic cancer survivors
A web-based mindfulness program is being tested to help breast and gynecologic cancer survivors who have sexual health concerns.
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Promoting open talks about sexual health after gynecologic cancer
A patient-focused program helps women with gynecologic cancer start and guide conversations about sexual health with their doctors.
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Modernizing Gynecologic Cancer Trial Rules to Enroll More Patients
Aims to make gynecologic cancer clinical trials more accessible to diverse patients so more people can benefit from new treatments.
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Virtual mindfulness program to improve sexual health after breast or gynecologic cancer
An online mindfulness program to help breast and gynecologic cancer survivors manage sexual pain, low desire, body image, and intimacy problems.
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Targeted treatment matching and better trial access for gynecologic cancers
This project helps people with gynecologic cancers get matched to targeted medicines based on their tumor's molecular profile and makes clinical trials easier to join.
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WNT4 gene changes and their role in gynecologic cancer risk and treatment response
This work is looking at whether a common change in the WNT4 gene raises risk and makes ovarian and other gynecologic cancers harder to treat, especially for women from diverse racial backgrounds.
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Improving Conversations About Sexual Health After Gynecologic Cancer
This project helps women who have had gynecologic cancer feel more confident and prepared to talk with their doctors about sexual health concerns.
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Improving sleep for women who have survived gynecologic cancer
This study is looking for ways to help women who have survived gynecologic cancer get better sleep, since many of them struggle with sleep issues, and it will explore natural methods to improve their sleep and overall well-being.
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Improving communication about sexual health for women after gynecologic cancer treatment
This study is designed to help women who have been treated for gynecologic cancer talk more openly about their sexual health with their doctors, using a special program called Starting the Conversation – Gynecologic Cancer, to make these important discussions easier and less stressful.
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Helping older women with gynecologic cancer recover their strength and function
This study is looking at older women with advanced gynecologic cancers, like ovarian and uterine cancer, to understand how their health and strength change over time, so we can find better ways to help them recover and improve their quality of life.
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Improving sexual health for breast and gynecologic cancer survivors through mindfulness.
This study is looking at how a friendly online program called Mindful After Cancer can help breast and gynecologic cancer survivors improve their sexual health after treatment.
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Investigating how WNT4 affects gynecologic cancer disparities
This study is looking at how a gene called WNT4 might affect ovarian cancer in women, especially how it could influence cancer growth and treatment responses, with the hope of finding better ways to help patients.
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Targeting harmful p53 mutations in gynecologic cancers
This study is looking at new, personalized treatments for ovarian and endometrial cancers linked to changes in the p53 gene, using cutting-edge techniques to help create options that work better for patients based on their specific tumor characteristics.
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Improving access to targeted therapies for gynecologic cancer patients
This study is all about helping more people with gynecologic cancers, especially endometrial cancer, find the right treatments by matching them with targeted therapies based on their unique cancer profiles, while also making sure that everyone, especially those from underrepresented groups, has a fair chance to join cl
Related topics
Quick answers
How many Gynecologic Cancer clinical trials are recruiting right now?
64, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 18 countries. The most sites are in United States (26 trials), Italy (11 trials), Canada (9 trials), France (5 trials), Germany (3 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 5, Phase 1: 3, Phase 3: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.