Mechanisms for Laser-Induced Rejuvenation in Skin Cancer Risk Reduction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers are investigating how Fractionated Laser Resurfacing after aging skin affects a population at risk for skin cancer, aiming to identify the cellular source of youth-like UVB responses seen after treatment. The study enrolls adults undergoing abdominoplasty to collect tissue samples and study fibroblast origins following laser treatment. Methods involve observing post-laser tissue changes and analyzing cell lineage in collaboration with the university’s pharmacology translational unit. The trial is interventional but does not specify a traditional randomization or control group.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult males and females 18 and older
* Able to comprehend procedures and risks
* Planning to undergo abdominoplasty surgery
* Minimum amount of skin to be removed is 50 x 20cm

Exclusion Criteria:

* Medical history of not well-controlled diabetes. This is defined as a subject who needs high doses of insulin, recent history of hospitalization for diabetes-related complications, or poor wound health as evidenced by diabetic ulcers. Subjects who have been deemed healthy enough for abdominoplasty surgery would tend to suggest that their diabetes should not be an issue. However, if the subjects have diabetic complications as outlined above, they could affect the wound healing which is the object of this protocol so they would be excluded.
* Pregnant or nursing
* History of pathologically abnormal wound healing such as keloidal scars
* Existing tattoos on the abdomen that are so extensive that they could interfere with the study

Where it's running

• Pharmacology Translational Unit
  Fairborn, Ohio, United States Recruiting

Study contacts

• Principal investigator: Jeffrey Travers, MD, PhD — Wright State University
• Study coordinator: Manager, Clinical Research Operations
• Email: pturesearch@wrightstatephysicians.org
• Phone: 937-245-7500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.