Condition

Gastrointestinal Cancer clinical trials and research

• 47Clinical trials
• 15NIH research projects
• 15Countries

Newest Gastrointestinal Cancer clinical trials

All recruiting trials (47)

• Frailty before GI cancer surgery: does frailty predict post-op outcomes in older adults?

  This study tests whether frailty measured before surgery can predict complications and recovery in patients 60 and older undergoing elective gastrointestinal cancer surgery.

  Recruiting Van Training and Research Hospital · Van, Van · NCT07815392

• Biological Collection to Help Create Models for Digestive Cancers and IBD

  Researchers are gathering tissue and biological samples from patients with inflammatory bowel disease or digestive cancers to build personalized models and test new therapies.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07782203

• Blood extracellular vesicles to detect chemotherapy-related nerve damage.

  We will test whether tiny blood particles called extracellular vesicles can predict who will develop chemotherapy-induced peripheral neuropathy in adults receiving taxane, platinum, or antimitotic chemotherapy.

  Recruiting Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan · NCT07558447

• High-precision detection of leftover cancer using a liquid-biopsy platform (SHERLOCK)

  This project will test whether sensitive blood and other fluid tests for circulating tumor DNA can find leftover cancer (minimal residual disease) in adults treated with curative intent for breast, lung, melanoma, gynecologic, or genitourinary cancers.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07524114

• Dabrafenib and trametinib for rare cancers with BRAF V600 mutations

  This arm tests whether dabrafenib and trametinib can help adults, children, and teens with cancers that have a BRAF V600 mutation.

  Recruiting at 15 sites Phase 2/3 Cancer Research UK · Belfast and 26 other locations · NCT07440290

• XH001 with neoantigen vaccine–primed tumor-specific T cells for advanced gastrointestinal cancer

  This trial tests whether combining XH001 injections with T cells activated by a tumor neoantigen vaccine is safe and can shrink tumors or extend life in adults with advanced gastrointestinal cancer.

  Recruiting Phase 1 Beijing GoBroad Hospital · Beijing · NCT07329894

• DB-1324 in advanced gastrointestinal tumors

  This study tests a new drug, DB-1324, in people with advanced or metastatic gastrointestinal cancers to see if it is safe and tolerable and to get an early sense of its activity against tumors.

  Recruiting at 9 sites Phase 1/2 DualityBio Inc. · Port Saint Lucie, Florida and 8 other locations · NCT07263594

• Intraoperative imaging of gastrointestinal cancers using pafolacianine (CYTALUX™)

  This trial will test whether an injection of CYTALUX™ (pafolacianine) with near-infrared imaging helps surgeons find gastric, esophageal, or appendiceal adenocarcinomas during surgery in adults.

  Recruiting Phase 4 Cedars-Sinai Medical Center · Los Angeles, California · NCT07124351

• DR30206 with standard chemotherapy for advanced gastrointestinal cancers

  This trial tests whether adding the experimental drug DR30206 to standard chemotherapy helps adults with advanced or metastatic gastrointestinal cancers.

  Recruiting Phase 1/2 Zhejiang Doer Biologics Co., Ltd. · Guangzhou, Guangdong · NCT07056777

• Program to support patients with advanced gastrointestinal and gynecologic cancers

  This study is testing a new support program to see if it can help people with advanced gastrointestinal and gynecologic cancers feel better and need less hospital care.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06936878

• Evaluating fatigue and molecular mechanisms in cancer patients undergoing combined chemotherapy and radiation therapy

  This study is testing how fatigue affects cancer patients getting both chemotherapy and radiation therapy, and whether certain genes and molecules are linked to how tired they feel during treatment.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06633224

• Optimizing care for young cancer patients with gastrointestinal tumors

  This study is trying to understand the needs of young cancer patients with gastrointestinal tumors to improve their care and support services.

  Recruiting University Hospital Heidelberg · Heidelberg, Baden-Wurttemberg · NCT06621277

• Investigating QXL138AM for patients with advanced solid tumors and multiple myeloma

  This study is testing a new drug called QXL138AM to see if it can safely help people with advanced solid tumors and multiple myeloma.

  Recruiting at 11 sites Phase 1 Nammi Therapeutics Inc · Los Angeles, California and 10 other locations · NCT06582017

• Exploring sleep behaviors in cancer patients and their caregivers

  This study is testing two different programs to see if they can help improve sleep quality for people recently diagnosed with gastrointestinal cancer and their caregivers.

  Recruiting University of Miami · Coral Gables, Florida and 1 other locations · NCT06569693

• Using pafolacianine for imaging during surgery for gastrointestinal cancer

  This study is testing if a special imaging drug called pafolacianine can help doctors find cancer spots better during surgery for adults with gastrointestinal cancer.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT06511037

• Evaluating RAS(ON) Inhibitors for Gastrointestinal Solid Tumors

  This study is testing new RAS(ON) inhibitors combined with standard treatments to see if they can help people with certain types of gastrointestinal cancers that have RAS mutations.

  Recruiting at 32 sites Phase 1/2 Revolution Medicines, Inc. · Chandler, Arizona and 31 other locations · NCT06445062

• Goals of care discussions for patients with advanced lung and gastrointestinal cancer in the emergency department

  This study is testing if having goals of care conversations in the emergency department can improve the quality of life for patients with advanced lung and gastrointestinal cancers and help them spend less time in the hospital.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06420206

• Palliative radiotherapy for pelvic soft tissue tumors

  This study is testing if giving fewer doses of palliative radiotherapy can help relieve symptoms and improve quality of life for patients with pelvic soft tissue tumors from gastrointestinal, urological, or gynecological cancers.

  Recruiting at 11 sites Sykehuset Telemark · Ålesund and 10 other locations · NCT06398314

• Injecting engineered immune cells to treat advanced solid tumors

  This study is testing a new treatment that uses specially modified immune cells taken from patients' tumors to see if it can help people with advanced cancers that haven't responded to other treatments.

  Recruiting Phase 1 Shanghai Juncell Therapeutics · Shanghai · NCT06375187

• Comparing two methods for examining gastrointestinal lesions

  This study is testing whether a new imaging system for examining gastrointestinal lesions works better than the standard method for people undergoing endoscopic ultrasound.

  Recruiting Orlando Health, Inc. · Orlando, Florida · NCT06340620

• Improving care for Black patients with gastrointestinal cancer

  This study is trying to improve cancer care for Black patients with gastrointestinal cancers by ensuring they get the right tests and treatments while helping us understand the challenges they face.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06263088

• Using voice technology to improve post-surgery care for gastrointestinal cancer patients

  This study is testing whether a voice technology system can help improve the recovery and care of patients after surgery for gastrointestinal cancer compared to standard care.

  Recruiting at 2 sites Medstar Health Research Institute · Baltimore, Maryland and 1 other locations · NCT06190730

• BGT007 injection for treating difficult digestive system tumors

  This study is testing a new injection called BGT007 to see if it can safely help people with tough digestive system tumors that keep coming back or don’t respond to other treatments.

  Recruiting Early Phase 1 The Affiliated Hospital of Xuzhou Medical University · Xuzhou, JangSu · NCT06104241

• Combining sacituzumab govitecan with capecitabine for advanced gastrointestinal cancers

  This study is testing if combining two cancer treatments, sacituzumab govitecan and capecitabine, can help people with advanced gastrointestinal cancers that haven't improved with standard treatments.

  Recruiting Phase 1 Henry Ford Health System · Detroit, Michigan · NCT06065371

• Total neoadjuvant chemotherapy for advanced gastric and gastroesophageal cancer

  This study is testing two different chemotherapy plans for people with advanced stomach cancer to see which one helps them better tolerate treatment and successfully have surgery.

  Recruiting at 2 sites Phase 2/3 Ukrainian Society of Clinical Oncology · Vilnius and 1 other locations · NCT06028737

• Collection of blood and tissue samples from patients with upper aerodigestive cancers

  This study is collecting blood and tissue samples from patients with certain cancers to see how their treatments affect the immune system and to help improve future cancer therapies.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT05995821

• Comparing two radiation therapy techniques for advanced solid tumors

  This study is testing whether a new type of radiation therapy works better than the standard method for treating advanced solid tumors that have spread, to see if it can improve outcomes for patients needing palliative care.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05837767

• Understanding patient experiences after canceled cancer surgeries

  This study looks at how patients feel after their planned gastrointestinal cancer surgeries are canceled to better understand their needs and improve care.

  Recruiting at 2 sites Linkoeping University · Linköping and 1 other locations · NCT05808712

• Effects of exercise on side effects from gastrointestinal cancer treatment

  This study is testing whether a safe amount of treadmill walking can help people undergoing treatment for gastrointestinal cancer feel better and manage side effects.

  Recruiting at 8 sites Phase 2 Memorial Sloan Kettering Cancer Center · Hartford, Connecticut and 7 other locations · NCT05789485

• Monitoring disease outcomes and side effects in patients with gastrointestinal cancers and sarcomas

  This study is trying to see how standard treatments for gastrointestinal cancers and sarcomas affect patients' health and side effects over time.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT05743426

• Using Pemigatinib for Advanced Gastrointestinal Cancer with FGFR Alterations

  This study is testing if a drug called Pemigatinib can help people with advanced gastrointestinal cancer that has certain genetic changes and hasn't worked with other treatments.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT05651672

• Using PSMA imaging for gastrointestinal tumors

  This study is testing if a special type of imaging called PSMA-PET can help find and understand gastrointestinal tumors better in patients with gastroenteropancreatic neuroendocrine neoplasms.

  Recruiting Wuerzburg University Hospital · Würzburg, Bavaria · NCT05547919

• Personalised azacitidine combination therapy using AI-guided drug selection and dosing

  This study tests whether AI tools can pick the best azacitidine drug combination and personalise dosing for adults with certain solid tumours using each person's biopsy sample.

  Recruiting Phase 1/2 National University Hospital, Singapore · Singapore · NCT05381038

• Improving access to cancer trials for underrepresented minorities

  This study is trying out a new program to help people from underrepresented backgrounds with advanced cancers learn about and access genomic testing for clinical trials.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 2 other locations · NCT05375643

• Improving care for cancer survivors with chronic conditions

  This study is testing a new care approach to see if it can help cancer survivors with other health issues get better support and improve their overall health.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05323409

• Combining Neratinib and Fam-Trastuzumab Deruxtecan for Advanced Gastro-esophageal Cancer

  This study is testing a new combination of two cancer drugs to see if it can safely help people with advanced gastro-esophageal cancer that has a specific gene change.

  Recruiting at 3 sites Phase 1 Fox Chase Cancer Center · Palo Alto, California and 2 other locations · NCT05274048

• Registry for patients treated with electroporation for cancer

  This study is collecting information from cancer patients who have received a new treatment using electroporation with chemotherapy or calcium to see how well it works and what side effects it may cause.

  Recruiting Mirai Medical · London · NCT04929912

• Using nanoparticles to enhance radiation treatment for brain metastases

  This study is testing if adding special nanoparticles to radiation therapy can help people with brain metastases get better results than radiation alone.

  Recruiting at 2 sites Phase 2 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT04899908

• Personalized chemotherapy for abdominal cancer treatment

  This study is testing a new way to personalize chemotherapy for patients with abdominal cancer by trying different treatments on their tumor samples before using them during surgery.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT04847063

• Using EUS to analyze circulating tumor DNA in gastrointestinal cancer patients

  This study is testing if a new way to collect and analyze tumor DNA from the blood of patients with gastrointestinal cancers can help doctors better stage the cancer and monitor for any return after treatment.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT04782557

• Improving cancer care for older adults with gastrointestinal cancers

  This study is testing a new way to improve cancer care for older adults with gastrointestinal cancers by adding special consultations to their treatment plans.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT04674267

• Using blood tests to assess early treatment response in cancer patients

  This study is testing if blood tests that look for cancer DNA can help doctors see how well treatment is working for patients with different types of solid tumors.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT04354064

• Effects of Atezolizumab on Cancer Patients with Sensitive Tumor DNA or RNA

  This study is testing if atezolizumab can help cancer patients with certain tumor types that show they might respond well to the treatment.

  Recruiting Phase 2 British Columbia Cancer Agency · Vancouver, British Columbia and 1 other locations · NCT04273061

• Oncolytic viral therapy for solid tumors

  This study is testing a new treatment using a modified virus to see if it can help people with solid tumors, like gastrointestinal cancers, feel better when combined with other therapies.

  Recruiting Phase 1/2 Binhui Biopharmaceutical Co., Ltd. · Beijing, Beijing Municipality · NCT03866525

• Using modified immune cells to target specific cancer mutations

  This study is testing a new treatment that uses modified immune cells to target and attack tumors with a specific cancer mutation in patients with advanced pancreatic and colorectal cancer.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03190941

• Collecting tumor samples to improve cancer treatment matching

  This study is collecting tumor samples from patients with advanced cancer to see if analyzing their genes can help doctors find the best treatments for them.

  Recruiting at 2 sites University Health Network, Toronto · Hamilton, Ontario and 6 other locations · NCT02906943

• Collecting blood and tissue samples from patients with gastrointestinal cancer

  This study is collecting blood and tissue samples from people with gastrointestinal cancers to see how their immune system and gut bacteria affect the disease and to help improve future treatments.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01313442

NIH-funded research (15)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Translational science to understand how GI cancers start and grow in Barrett’s esophagus

  This grant looks at how Barrett’s esophagus may lead to esophageal cancer and colorectal cancer and what early signs could hint at cancer forming.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11395527

• Gastrointestinal Cancer SPORE at Vanderbilt-Ingram Cancer Center

  A multi-year NIH grant supports focused work on colorectal cancer at Vanderbilt with emphasis on collaborative research, resources, and patient advocacy to accelerate discoveries and potential treatments.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11393790

• ctDNA-based monitoring to guide extra treatment after colorectal cancer surgery

  A doctor-led program will use a blood test to find tiny cancer traces after surgery for Stage III colorectal cancer and see if additional therapy can improve chances of cure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11362598

• Acceptance and Commitment Therapy to Help Fatigue and Caregiver Burden in Advanced GI Cancer

  A patient-facing trial will test a telephone-based therapy to help people with advanced gastrointestinal cancer manage fatigue and reduce the stress on their family caregivers.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11330492

• Predicting GI cancer outcomes using routine blood data in everyday care

  A doctor-researcher will develop and test computer models that use routine blood test results to flag potential gastrointestinal cancers during normal clinic visits.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11330455

• Understanding GI Cancer Disparities in Native Hawaiians and Pacific Islanders

  A NIH-funded project aims to understand why Native Hawaiians and Pacific Islanders have different gastrointestinal cancer outcomes and how social factors influence these differences.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11280408

• Vanderbilt program to improve colorectal cancer care

  Vanderbilt researchers are developing new tests and treatments to help people with colorectal cancer live longer and healthier lives.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11196622

• Early changes in the gut that lead to colon and esophagus cancer

  This project looks at tissue and molecular changes in people with Barrett’s esophagus or colon polyps to help catch or prevent cancer earlier.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11171762

• Blood tests to track gastrointestinal cancer after treatment

  This project explores if a special blood test can find tiny amounts of cancer left after surgery and help guide further treatment for people with gastrointestinal cancers.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11136278

• Helping advanced gastrointestinal cancer patients and their caregivers manage fatigue and stress

  This study is looking at how a special therapy called Acceptance and Commitment Therapy (ACT) can help people with advanced gastrointestinal cancer feel less tired and improve their overall well-being, while also supporting their family caregivers who may be feeling overwhelmed. The program includes helpful phone calls

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11077263

• Understanding how gastrointestinal cancers start and progress

  This study is looking into how certain changes in the body can lead to gastrointestinal cancers like colorectal and esophageal cancer, with the goal of finding better ways to prevent and catch these cancers early, which could help patients get better treatment options.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10913595

• Using blood tests to monitor cancer treatment in patients with colorectal cancer

  This study is looking at how a simple blood test can help find tiny traces of cancer in people with Stage III colorectal cancer after surgery, to see if it can help identify those who might need extra treatment to prevent the cancer from coming back.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10894923

• Investigating new genetic factors that influence gastrointestinal cancer and immune response.

  This study is looking at how certain genetic changes in gastrointestinal cancer can affect the immune system's ability to fight the disease, with the goal of finding new treatment options that are better suited for patients like you.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10892278

• Improving diagnosis of gastrointestinal cancers using prediction models.

  This study is looking at how we can use new tools to help doctors spot gastrointestinal cancers earlier by examining blood test results, making it easier for patients to get the care they need sooner.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10877730

• Using virtual resistance training to help patients with advanced upper gastrointestinal cancer during chemotherapy

  This study is looking at whether a virtual exercise program can help people with advanced upper gastrointestinal cancers feel stronger and better during chemotherapy, by making it easier for them to work out at home compared to regular exercise sessions.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-10791823

Related topics

Quick answers

How many Gastrointestinal Cancer clinical trials are recruiting right now?

47, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (26 trials), China (7 trials), Canada (3 trials), Germany (2 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 6, Phase 1: 6, Phase 2: 4, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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