Glycosylation patterns in skin cancer and new therapies
Official title: Functional Landscape of Glycosylation in Skin Cancer
Funded at Emory University · NIH-11231958 · Data updated 2026-11-12
A research project at Emory is exploring how protein sugars change in skin cancer to uncover new treatment targets and therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | February 1, 2023 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 4R00CA277591-03 |
| Project ID | NIH-11231958 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with squamous cell carcinoma or related skin conditions may benefit from future therapies developed from this research.
✕Less likely to help
Direct patient benefit is contingent on future trials and therapies; early-stage basic science findings may not directly translate to treatment.
What this research studies
This project uses mouse skin as a model to map how glycosylation changes in squamous cell carcinoma over time, with advanced techniques to see where these sugars and glycoproteins are located. It includes a large-scale genetic screen to identify which glycan-related genes affect cancer development, and later combines proteomics, single-cell analysis, and drug screening to find potential therapies. The goal is to understand how altered glycosylation drives tumor progression and how we might disrupt it to help patients with skin cancer.
Why it matters
Potential benefit: If successful, the work could reveal new targets for therapy and strategies to treat or prevent progression of skin cancer.
How similar studies have gone: Previous studies in cancer glycosylation have identified important roles for glycans, suggesting this approach could yield meaningful insights but remains to be validated in skin cancer.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Kudelka, Matthew Robert — Emory University
- Study coordinator: Kudelka, Matthew Robert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.