Investigating how skin cells contribute to the development of skin cancer.
Official title: The Role of Dermal Fibroblasts in Skin Cancer
Funded at Veterans Health Administration · NIH-11105992 · Data updated 2026-11-12
This study is looking at how skin cells get damaged and how that might help a common type of skin cancer, basal cell carcinoma, grow, especially in veterans, by exploring the role of certain cells in the skin that could be influencing this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Decatur, UNITED STATES) |
| Project start | April 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5IK2BX005370-05 |
| Project ID | NIH-11105992 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of skin cancer, particularly veterans who are at higher risk for basal cell carcinoma.
✕Less likely to help
Patients who do not have a history of skin cancer or those with other unrelated skin conditions may not benefit from this research.
What this research studies
This research focuses on basal cell carcinoma (BCC), the most common skin cancer, particularly in veterans. It aims to understand how DNA damage in skin cells activates signaling pathways in dermal fibroblasts, which may promote cancer development. By using advanced techniques such as live imaging and patient-derived models, the study will explore the role of cancer-associated fibroblasts (CAFs) in BCC progression. The goal is to uncover the mechanisms by which these fibroblasts influence skin cancer behaviors.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating basal cell carcinoma.
How similar studies have gone: Previous research has shown that targeting fibroblast signaling can impact cancer progression, suggesting potential for success in this area.
Where this research is happening
-
Veterans Health Administration
Decatur, United States Active
Researchers
- Principal investigator: Seldin, Lindsey Nicole — Veterans Health Administration
- Study coordinator: Seldin, Lindsey Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.