Psycho-physiological profiling of people with low versus high heat resilience
Official title: Physiological Phenotyping
Run by University of Thessaly · NCT07510061 · Data updated 2026-11-12
This project will test whether controlled heat and UV exposures plus physiological and psychological measurements can identify healthy adults who are more or less resilient to heat.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | University of Thessaly Academic / other |
| Drugs / interventions | radiation |
| Locations | 2 sites (Copenhagen and 1 other locations) |
| Status | Recruiting |
| Started | November 1, 2025 |
| Main results expected | April 30, 2027 |
| Study ends | April 30, 2027 |
| Registry record updated | April 3, 2026 |
| Trial ID | NCT07510061 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal participants are healthy adults aged 18–65 living in Denmark or Greece who can undergo controlled heat exposure, provide blood, urine and optional skin biopsy samples, have Fitzpatrick skin type I–IV, and have not had recent heat acclimatization or extensive sun exposure.
✕Probably not a fit
People with cardiovascular, metabolic, neurological, or dermatological disease, a history of heat-related illness, pregnancy or breastfeeding, use of medications affecting thermoregulation, smokers, or those outside the 18–65 age range are excluded and unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The project combines controlled laboratory heat and ultraviolet exposures with behavioral and physiological measurements to profile heat tolerance in adults from northern and southern Europe. Participants will complete heat-exposure and light-exercise protocols while researchers collect blood, urine, and optional skin biopsy samples and record cardiovascular, thermoregulatory, and psychological responses. Data from Copenhagen and Trikala sites will be integrated and analyzed with machine-learning algorithms to derive predictive signatures of heat vulnerability. Field investigations in ecological settings will complement lab findings to improve real-world applicability and support development of personalized alert and advisory tools.
Why it matters
Potential benefit: If successful, this work could enable personalized warnings and guidance that reduce heat-related illness and decrease strain on healthcare services.
How similar studies have gone: Prior laboratory and epidemiological research has linked physiological and behavioral factors to heat vulnerability, but combining controlled exposures across climates with machine-learning for personalized alerts is largely novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Study Population Healthy adult volunteers residing in Denmark (Northern Europe) or Greece (Southern Europe). Inclusion Criteria * Age 18-65 years (or your protocol-specific age range) * Healthy as determined by medical history screening questionnaire * Able to provide written informed consent * Able to complete heat exposure and light exercise protocol * No heat acclimatization or extensive sun exposure in the previous 4 weeks * Fitzpatrick skin type I-IV (if applicable for UV testing) * Willing to undergo blood sampling, urine collection, and skin biopsy Exclusion Criteria * History of cardiovascular, metabolic, neurological, or dermatological disease * History of heat-related illness (e.g., heat stroke) * Use of medications affecting thermoregulation or cardiovascular function * Smoking or substance abuse * Pregnancy or breastfeeding * Abnormal ECG or uncontrolled hypertension * Recent severe sunburn or UV treatment * Contraindications to skin biopsy * Inability to tolerate heat exposure during screening
Where it's running
-
Københavns Universitet
Copenhagen, Denmark Recruiting -
Department of Physical Education and Sport Science
Trikala, Thessaly, Greece Recruiting
Study contacts
- Principal investigator: Andreas D Flouris, PhD — 1FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece
- Study coordinator: Maria Vliora, PhD
- Email: mvliora@gmail.com
- Phone: 6979642540
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.